A novel mechanism in regulating drug sensitivity, growth, and apoptosis of bortezomib-resistant multiple myeloma cells: the USP4/KLF2/HMGA2 cascade [PDF]
Journal of Orthopaedic Surgery and ResearchBackground Multiple myeloma (MM) is a malignant disorder originating from plasma cells. Bortezomib (BTZ) resistance has become a huge obstacle to MM treatment.
Ziyi Liu +7 more
doaj +5 more sources
Hemodynamic forces prevent myxomatous valve disease in mice through KLF2/4 signaling. [PDF]
J Clin InvestMyxomatous valve disease (MVD) is the most common form of cardiac valve disease in the developed world. A small fraction of MVD is syndromic and arises in association with matrix protein defects such as those in Marfan syndrome, but most MVD is acquired ...
Pace JA +17 more
europepmc +3 more sources
Tannic acid as a plant-derived polyphenol exerts vasoprotection via enhancing KLF2 expression in endothelial cells [PDF]
Scientific Reports, 2017 The transcription factor Kruppel-like factor 2 (KLF2) is a critical anti-inflammatory and anti-atherogenic molecule in vascular endothelium. Enhancing KLF2 expression and activity improves endothelial function and prevents atherosclerosis.
Yanni Xu +6 more
doaj +2 more sources
The Journal of Pathology: Clinical Research, 2023 Krüppel‐like factor 2 (KLF2) belongs to the zinc finger family and is thought to be a tumor suppressor gene due to its low expression in various cancer types.
Jia Li +3 more
doaj +2 more sources
KLF2 may suppress chicken adipogenesis by enhancing the GATA2 transcription [PDF]
Scientific ReportsKruppel-like factor 2 (KLF2) acts as an essential modulator of adipogenesis; nevertheless, the exact molecular pathways governing its role remain uncharacterized. This investigation characterized the expression profile of KLF2 in human adipose tissue and
Tingting Zhang +6 more
doaj +2 more sources
Mechanosensitive Channel PIEZO1 Senses Shear Force to Induce KLF2/4 Expression via CaMKII/MEKK3/ERK5 Axis in Endothelial Cells [PDF]
Cells, 2022 Shear stress exerted by the blood stream modulates endothelial functions through altering gene expression. KLF2 and KLF4, the mechanosensitive transcription factors, are promoted by laminar flow to maintain endothelial homeostasis.
Qi Zheng +12 more
doaj +2 more sources
Shear stress leads to the dysfunction of endothelial cells through the Cav-1-mediated KLF2/eNOS/ERK signaling pathway under physiological conditions [PDF]
Open Life Sciences, 2023 To investigate the mechanism of shear stress on endothelial cell dysfunction for providing a theoretical basis for the reduction of arteriovenous fistula dysfunction.
Lihua Wang +6 more
openalex +2 more sources
MiR-15b-3p weakens bicalutamide sensitivity in prostate cancer via targeting KLF2 to suppress ferroptosis [PDF]
Journal of CancerBicalutamide (BIC) resistance impedes the treatment of prostate cancer (PCa) and seems to involve ferroptosis; however, the underlying mechanism remains unclear.
Chunlin Zhang +11 more
openalex +2 more sources
A crucial role of KLF2-regulated mitochondrial oxidative phosphorylation in maintaining the stemness of mesenchymal stem cells derived from bone marrow [PDF]
Cell & BioscienceMesenchymal stem cells (MSCs) have many uses in tissue engineering and clinical applications. However, maintaining their stemness during in vitro expansion is challenging.
Zhiyuan Gong +7 more
doaj +2 more sources
Krüppel-like Factor 2 (KLF2) in the Regulation of Lipid Accumulation, ROS, and Mitochondrial Functions During Foam Cell Formation in RAW264.7 Cells [PDF]
BiologyFoam cell formation, a hallmark of early atherosclerotic lesion development, is closely associated with mitochondrial dysfunction and excessive reactive oxygen species (ROS) production.
Md Sariful Islam Howlader +4 more
doaj +2 more sources