Results 91 to 100 of about 18,442 (279)

BHLHE40 Orchestrates Effector Tissue‐Resident Memory CD8+ T Cells and Limits Long‐Term Survival of Kidney Graft

Advanced Science, EarlyView.
An effector subset of TRM, defined as CD49a+PD1hi CD8+ TRM, represents a BHLHE40‐orchestrated resident immune component that, rather than circulating cells, plays as a major contributor to allograft rejection. ABSTRACT Tissue‐resident memory T cells (TRM), which function against tumors, infections, and non‐self antigens in organ transplantation ...
Junbo Li, Bo Yang, Tianhui Pan, Xi Zhou, Zhibo Ma, Du Tang, Bowen Xie, Jing Liu, Zhishui Chen, Peixiang Lan   +9 more
wiley   +1 more source

Comprehensive analysis of KLF2 as a prognostic biomarker associated with fibrosis and immune infiltration in advanced hepatocellular carcinoma

BMC Bioinformatics, 2023
Purpose Most Hepatocellular carcinoma (HCC) patients are in advanced or metastatic stage at the time of diagnosis. Prognosis for advanced HCC patients is dismal.
Xue-Qin Chen, Jie Ma, Di Xu, Zuo-Lin Xiang   +3 more
doaj   +1 more source

Shear stress regulation of miR-93 and miR-484 maturation through nucleolin. [PDF]

, 2019
Pulsatile shear (PS) and oscillatory shear (OS) elicit distinct mechanotransduction signals that maintain endothelial homeostasis or induce endothelial dysfunction, respectively.
Chen, Lili, Chen, Shanshan, Chien, Shu, Gongol, Brendan, Han, Yue, He, Ming, Huang, Po-Hsun, Johnson, David A, Kang, Jian, Li, Jie, Li, Yi-Shuan, Liu, Jun-Hui, Lytle, Christian, Marin, Traci, Martin, Marcy, Shyy, John Y-J, Sun, Wei, Wang, Shen-Chih, Zhang, Jiao   +18 more
core  

Moving Domain Computational Fluid Dynamics to Interface with an Embryonic Model of Cardiac Morphogenesis [PDF]

, 2013
Peristaltic contraction of the embryonic heart tube produces time- and spatial-varying wall shear stress (WSS) and pressure gradients (∇P) across the atrioventricular (AV) canal.
Beebe, Tyler, Cao, Hung, Chi, Neil C., Hsiai, Tzung K., Kung, Ethan, Lee, Juhyun, Lien, Ching-Ling, Marsden, Alison L., Miller, Yury, Moghadam, Mahdi Esmaily, Roman, Beth L., Xu, Xiaolei   +11 more
core   +7 more sources

Induction of KLF2 by exercise activates eNOS to improve vasodilatation in diabetic mice.

Diabetes, 2023
Diabetic endothelial dysfunction associated with diminished endothelial nitric oxide synthase (eNOS) activity accelerates the development of atherosclerosis and cardiomyopathy.
Jiang-Yun Luo, Chak Kwong Cheng, L. Gou, Lei He, Lei Zhao, Yang Zhang, Li Wang, C. Lau, A. Xu, Alex F. Chen, Yu Huang   +10 more
semanticscholar   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

KLF2 Is a Novel Transcriptional Regulator of Endothelial Proinflammatory Activation [PDF]

The Journal of Experimental Medicine, 2004
The vascular endothelium is a critical regulator of vascular function. Diverse stimuli such as proinflammatory cytokines and hemodynamic forces modulate endothelial phenotype and thereby impact on the development of vascular disease states. Therefore, identification of the regulatory factors that mediate the effects of these stimuli on endothelial ...
SenBanerjee, Sucharita, Lin, Zhiyong, Atkins, G. Brandon, Greif, Daniel M., Rao, Ravi M., Kumar, Ajay, Feinberg, Mark W., Chen, Zhiping, Simon, Daniel I., Luscinskas, F. William, Michel, Thomas M., Gimbrone, Michael A., García-Cardeña, Guillermo, Jain, Mukesh K.   +13 more
openaire   +2 more sources

a study to discover novel tumor-specific mutations [PDF]

, 2015
Background Splenic marginal zone lymphoma (SMZL) is an indolent B-cell non- Hodgkin lymphoma and represents the most common primary malignancy of the spleen. Its precise molecular pathogenesis is still unknown and specific molecular markers for diagnosis
Biskup, Saskia, Döring, Claudia, Hansmann, Martin-Leo, Küppers, Ralf, Lucioni, Marco, Paulli, Marco, Peveling-Oberhag, Jan, Scholtysik, René, Schubach, Max, Sellmann, Ludger, Walter, Dirk, Wolters, Franziska, Zeuzem, Stefan   +12 more
core   +1 more source

Targeting the Mapk13‐Tcf1‐Slc7a5 Axis via One‐Carbon Metabolic Regulation to Prevent Chronic Allograft Vasculopathy

Advanced Science, EarlyView.
This study emphasizes the role of the Mapk13‐Tcf1‐Slc7a5‐methionine metabolism axis in stem‐like CD4+ T cells. Moreover, it uncovers the mechanism through which limiting one‐carbon metabolism in CD4+ stem‐like T cells suppresses the tide of chronic allograft vasculopathy, offering potential targets to promote long‐term graft survival.
Wang Yi, Di Wu, Jing Liu, Shi Chen, Liu Song, Bin Xie, Aini Xie, Peixiang Lan, Zhishui Chen   +8 more
wiley   +1 more source

Klf2 Is an Essential Factor that Sustains Ground State Pluripotency [PDF]

Cell Stem Cell, 2014
The maintenance of mouse embryonic stem cells (mESCs) requires LIF and serum. However, a pluripotent "ground state," bearing resemblance to preimplantation mouse epiblasts, can be established through dual inhibition (2i) of both prodifferentiation Mek/Erk and Gsk3/Tcf3 pathways.
Yeo, Jia-Chi, Jiang, Jianming, Tan, Zi-Ying, Yim, Guo-Rong, Ng, Jia-Hui, Göke, Jonathan, Kraus, Petra, Liang, Hongqing, Gonzales, Kevin Andrew Uy, Chong, Han-Chung, Tan, Cheng-Peow, Lim, Yee-Siang, Tan, Nguan-Soon, Lufkin, Thomas, Ng, Huck-Hui   +14 more
openaire   +4 more sources