Results 11 to 20 of about 18,442 (279)

The Role of KLF2 in the Regulation of Atherosclerosis Development and Potential Use of KLF2-Targeted Therapy [PDF]

Biomedicines, 2022
Kruppel like factor 2 (KLF2) is a mechanosensitive transcription factor participating in the regulation of vascular endothelial cells metabolism. Activating KLF2 in endothelial cells induces eNOS (endothelial nitric oxide synthase) expression, subsequent
Siarhei A. Dabravolski, Vasily N. Sukhorukov, Vladislav A. Kalmykov, Andrey V. Grechko, Nikolay K. Shakhpazyan, Alexander N. Orekhov   +5 more
doaj   +3 more sources

Krüppel-like Factor 2 (KLF2) in Immune Cell Migration [PDF]

Vaccines, 2021
Krüppel-like factor 2 (KLF2), a transcription factor of the krüppel-like family, is a key regulator of activation, differentiation, and migration processes in various cell types. In this review, we focus on the functional relevance of KLF2 in immune cell
Jens Wittner, Wolfgang Schuh
doaj   +5 more sources

KLF2 controls the apoptosis of neutrophils and is associated with disease activity of systemic lupus erythematosus

Arthritis Research & Therapy
Background Neutropenia is more common in patients with systemic lupus erythematosus (SLE) and is a major cause of life-threatening infections. The increased apoptosis of neutrophils is likely to be an essential cause of neutropenia in SLE.
Hongshuai Zhao, Zaichuan Lin, Peiwen Zhang, Jiayue Rao, Shumin Xu, Qing Luo, Junming Li   +6 more
doaj   +2 more sources

OGA promotes human dental pulp stem cell senescence and inhibits mitophagy by inhibition of O-GlcNAcylation of KLF2. [PDF]

BMC Oral Health
Dental pulp stem cells (DPSCs) aging impedes its application in tooth regeneration techniques, involving abnormal mitophagy. O-GlcNAcylation is a post-translational modification that regulates various cellular processes. Here, we aimed to investigate the
Ding Y, Ran Y.
europepmc   +2 more sources

KLF2 wt Allele [PDF]

, 2020
National Cancer Institute
openalex   +2 more sources

Primary cilia mediate Klf2-dependant Notch activation in regenerating heart [PDF]

Protein & Cell, 2020
Unlike adult mammalian heart, zebrafish heart has a remarkable capacity to regenerate after injury. Previous study has shown Notch signaling activation in the endocardium is essential for regeneration of the myocardium and this activation is mediated by ...
Xueyu Li, Qiang Lu, Yuanyuan Peng, Fang Geng, Xuelian Shao, Huili Zhou, Ying Cao, Ruilin Zhang   +7 more
doaj   +3 more sources

N6-methyladenosine modification of KLF2 may contribute to endothelial-to-mesenchymal transition in pulmonary hypertension [PDF]

Cellular & Molecular Biology Letters
Background Pulmonary hypertension (PH) is a progressive disease characterized by pulmonary vascular remodeling. Increasing evidence indicates that endothelial-to-mesenchymal transition (EndMT) in pulmonary artery endothelial cells (PAECs) is a pivotal ...
Kang Kang, Jingjing Xiang, Xingshi Zhang, Yuting Xie, Mengting Zhou, Le Zeng, Junhao Zhuang, Jiahao Kuang, Yuanyuan Lin, Bozhe Hu, Qianmin Xiong, Qing Yin, Qiang Su, Xiaoyun Liao, Jun Wang, Yanqin Niu, Cuilian Liu, Jinglin Tian, Deming Gou   +18 more
openalex   +2 more sources

UM171 suppresses breast cancer progression by inducing KLF2

Breast Cancer Research and Treatment
Breast cancer is the most frequent cancer in women with significant death rate. Morbidity is associated with drug resistance and metastasis. Development of novel drugs is unmet need. The aim of this study is to show potent anti-neoplastic activity of the
Xiaojuan Ran, Anling Hu, Yi Kuang, Chunlin Wang, Wuling Liu, Xiao Xiao, E. Zacksenhaus, Xiangdi Yu, Yaacov Ben-David   +8 more
semanticscholar   +3 more sources

Enhancing postmenopausal osteoporosis: a study of KLF2 transcription factor secretion and PI3K-Akt signaling pathway activation by PIK3CA in bone marrow mesenchymal stem cells

Archives of Medical Science
Introduction Mesenchymal stem cells can develop into osteoblasts, making them a promising cell-based osteoporosis treatment. Despite their therapeutic potential, their molecular processes are little known.
Wenjie Ma, Chen Li
doaj   +2 more sources

Mechanism of KLF2 in young mice with pneumonia induced by Streptococcus pneumoniae

Journal of Cardiothoracic Surgery
Background Streptococcus pneumoniae (Spn) is a major causative agent of pneumonia, which can disseminate to the bloodstream and brain. Pneumonia remains a leading cause of death among children aged 1–59 months worldwide.
Xiaoshuang Li, Weihua Xu, Tao Jing
doaj   +2 more sources