Endothelial γ-protocadherins inhibit KLF2 and KLF4 to promote atherosclerosis
Nature Cardiovascular ResearchAtherosclerotic cardiovascular disease (ASCVD) is the leading cause of mortality worldwide. Laminar shear stress from blood flow, sensed by vascular endothelial cells, protects from ASCVD by upregulating the transcription factors KLF2 and KLF4, which ...
Divyesh Joshi +14 more
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The FBW7-KLF2 axis regulates endothelial functions [PDF]
Cell Research, 2013 FBW7 tumor suppressor suppresses the growth and survival of tumor cells by promoting the degradation of several oncoproteins, and induces endothelial differentiation by modulating the NF1/RAS axis. A recent study in this issue of Cell Research showed that FBW7 further regulates endothelial functions via degrading transcription factor KLF2.
Yongchao Zhao, Yi Sun
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KLF2 controls proliferation and apoptosis of human spermatogonial stem cells via targeting GJA1
iScienceSummary: Human spermatogonial stem cells (SSCs) are essential for spermatogenesis and male fertility. However, molecular mechanisms regulating fate determinations of human SSCs remain elusive.
Wei Chen +6 more
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Lymph Node Exosomes Delivery Attenuates Myocardial Ischemia-Reperfusion Injury via Regulating PTEN-PI3K/Akt Pathway Mediated Myocardiocyte Apoptosis [PDF]
International Journal of NanomedicineShuaihua Qiao,1,2,* Baochuan Wu,3,* Lin Chen,3 Lingyu Ma,1 Yi Wang,3 Biao Xu,1 Rong Gu3 1Department of Cardiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu Province, People’s ...
Qiao S +6 more
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KLF2 is a clinical diagnostic and treatment biomarker of breast cancer
Frontiers in Cell and Developmental Biology, 2023 Background: As a highly prevalent malignancy among women worldwide, breast cancer, remains a critical public health issue necessitating the development of novel therapeutics and biomarkers.
Ya-Zhao Li +10 more
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MiRrored Regulation of KLF2 and KLF4 [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2012 A healthy organism demands much from its endothelium; constance in homeostatic control of blood fluidity, vascular tone, interaction with circulating blood cells, maintenance of barrier functions, and, when appropriate, creation of new blood vessels. Breakdown in any of these functions, anywhere in the 60,000 miles of vessels in the human body, leads ...
Anne, Hamik, Mukesh K, Jain
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Journal of Obstetrics and Gynaecology, 2023 Endometrial cancer (EC) is the most common gynaecologic malignancy. This study was to explore the role of kruppel-like factor 2 (KLF2) in EC cell behaviours. The expression of KLF2 in EC and its correlation with NPM1 were first predicted on the database.
Xiyun Cheng +2 more
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KLF2 Promotes Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Regulating Nrf2 Expression. [PDF]
Int Dent JChen J, Deng L.
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A requirement for Krüppel Like Factor‐4 in the maintenance of endothelial cell quiescence
Frontiers in Cell and Developmental Biology, 2022 Rationale and Goal: Endothelial cells (ECs) are quiescent and critical for maintaining homeostatic functions of the mature vascular system, while disruption of quiescence is at the heart of endothelial to mesenchymal transition (EndMT) and tumor ...
Victoria Mastej +4 more
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Krüppel-like factor 2 is required for normal mouse cardiac development. [PDF]
PLoS ONE, 2013 Krüppel-like factor 2 (KLF2) is expressed in endothelial cells in the developing heart, particularly in areas of high shear stress, such as the atrioventricular (AV) canal. KLF2 ablation leads to myocardial thinning, high output cardiac failure and death
Aditi R Chiplunkar +7 more
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