Results 31 to 40 of about 18,442 (279)

Renoprotective Effect of KLF2 on Glomerular Endothelial Dysfunction in Hypertensive Nephropathy

Cells, 2022
Kruppel-like factor 2 (KLF2) regulates endothelial cell metabolism; endothelial dysfunction is associated with hypertension and is a predictor of atherosclerosis development and cardiovascular events.
Eunjin Bae, Mi-Yeon Yu, Jong-Joo Moon, Ji-Eun Kim, Saram Lee, Sang-Woong Han, Dong-Jun Park, Yon-Su Kim, Seung-Hee Yang   +8 more
doaj   +1 more source

KLF2 Inhibits Chicken Preadipocyte Differentiation at Least in Part via Directly Repressing PPARγ Transcript Variant 1 Expression

Frontiers in Cell and Developmental Biology, 2021
Peroxisome proliferator-activated receptor gamma (PPARγ) is the master regulatory factor of preadipocyte differentiation. As a result of alternative splicing and alternative promoter usage, PPARγ gene generates multiple transcript variants encoding two ...
Tingting Cui, Tingting Cui, Tingting Cui, Tingting Cui, Jiaxin Huang, Jiaxin Huang, Jiaxin Huang, Yingning Sun, Yingning Sun, Yingning Sun, Yingning Sun, Bolin Ning, Bolin Ning, Bolin Ning, Fang Mu, Fang Mu, Fang Mu, Xin You, Xin You, Xin You, Yaqi Guo, Yaqi Guo, Yaqi Guo, Hui Li, Hui Li, Hui Li, Ning Wang, Ning Wang, Ning Wang   +28 more
doaj   +1 more source

KLF2 Orchestrates Pathological Progression of Infantile Hemangioma through Hemangioma Stem Cell Fate Decisions [PDF]

Journal of Investigative Dermatology
Qiming Chen, Hao Rong, Ling Zhang, Yanan Wang, Qian Bian, Jiawei Zheng   +5 more
openalex   +2 more sources

KLF2 regulates osteoblast differentiation by targeting of Runx2 [PDF]

Laboratory Investigation, 2019
Osteoblast differentiation plays a critical role in bone formation and maintaining balance in bone remodeling. Runt-related transcription factor 2 (Runx2) is a central transcription factor regulating osteoblast differentiation and promoting bone mineralization.
Zhenyang, Hou, Zhen, Wang, Yunxia, Tao, Jiaxiang, Bai, Binqing, Yu, Jining, Shen, Houyi, Sun, Long, Xiao, Yaozeng, Xu, Jun, Zhou, Zhirong, Wang, Dechun, Geng   +11 more
openaire   +2 more sources

Protective Role for Myeloid Specific KLF2 in Atherosclerosis [PDF]

Circulation Research, 2012
In this issue of Circulation Research , Lingrel and colleagues1 describe the phenotype of myeloid-specific Klf2 knockout mice. Although this transcription factor has long been known to be involved in protection from atherosclerosis, the cell type responsible was not clear.
Iftach, Shaked, Klaus, Ley
openaire   +2 more sources

Kruppel-like factor 2+ CD4 T cells avert microbiota-induced intestinal inflammation

Cell Reports, 2023
Summary: Intestinal colonization by antigenically foreign microbes necessitates expanded peripheral immune tolerance. Here we show commensal microbiota prime expansion of CD4 T cells unified by the Kruppel-like factor 2 (KLF2) transcriptional regulator ...
Tzu-Yu Shao, Tony T. Jiang, Joseph Stevens, Abigail E. Russi, Ty D. Troutman, Anas Bernieh, Giang Pham, John J. Erickson, Emily M. Eshleman, Theresa Alenghat, Stephen C. Jameson, Kristin A. Hogquist, Casey T. Weaver, David B. Haslam, Hitesh Deshmukh, Sing Sing Way   +15 more
doaj   +1 more source

Neutrophil extracellular traps in cardiac hypertrophy: a KLF2 perspective [PDF]

Journal of Clinical Investigation, 2022
About 6 million adults in the United States have heart failure, and the mortality five years after diagnosis remains high at approximately 50%. Incomplete understanding of disease pathogenesis limits therapeutics, especially in the case of heart failure with preserved ejection fraction, a condition commonly associated with cardiac hypertrophy ...
Dario F. Riascos-Bernal, Nicholas E.S. Sibinga   +1 more
openaire   +3 more sources

The KDM3A–KLF2–IRF4 axis maintains myeloma cell survival [PDF]

Nature Communications, 2016
AbstractKDM3A is implicated in tumorigenesis; however, its biological role in multiple myeloma (MM) has not been elucidated. Here we identify KDM3A–KLF2–IRF4 axis dependence in MM. Knockdown of KDM3A is toxic to MM cells in vitro and in vivo. KDM3A maintains expression of KLF2 and IRF4 through H3K9 demethylation, and knockdown of KLF2 triggers ...
Hiroto Ohguchi, Teru Hideshima, Manoj K. Bhasin, Gullu T. Gorgun, Loredana Santo, Michele Cea, Mehmet K. Samur, Naoya Mimura, Rikio Suzuki, Yu-Tzu Tai, Ruben D. Carrasco, Noopur Raje, Paul G. Richardson, Nikhil C. Munshi, Hideo Harigae, Takaomi Sanda, Juro Sakai, Kenneth C. Anderson   +17 more
openaire   +4 more sources

KLF2 and KLF4 control endothelial identity and vascular integrity [PDF]

JCI Insight, 2017
Maintenance of vascular integrity in the adult animal is needed for survival, and it is critically dependent on the endothelial lining, which controls barrier function, blood fluidity, and flow dynamics. However, nodal regulators that coordinate endothelial identity and function in the adult animal remain poorly characterized.
Panjamaporn, Sangwung, Guangjin, Zhou, Lalitha, Nayak, E Ricky, Chan, Sandeep, Kumar, Dong-Won, Kang, Rongli, Zhang, Xudong, Liao, Yuan, Lu, Keiki, Sugi, Hisashi, Fujioka, Hong, Shi, Stephanie D, Lapping, Chandra C, Ghosh, Sarah J, Higgins, Samir M, Parikh, Hanjoong, Jo, Mukesh K, Jain   +17 more
openaire   +2 more sources

Krüppel-Like Factor 2 Regulates Degradation of Type II Collagen by Suppressing the Expression of Matrix Metalloproteinase (MMP)-13

Cellular Physiology and Biochemistry, 2017
Background/Aims: Krüppel-like factor 2 (KLF2) plays an essential role in the inhibition of endothelial cell and macrophage activation during the inflammatory process.
Yuan Yuan, Honglue Tan, Pengyi Dai
doaj   +1 more source