Direct comparison of distinct naive pluripotent states in human embryonic stem cells [PDF]
, 2017 Until recently, human embryonic stem cells (hESCs) were shown to exist in a state of primed pluripotency, while mouse embryonic stem cells (mESCs) display a naive or primed pluripotent state.
Chuva de Sousa Lopes, Susana Marina +18 more
core +1 more source
Regulation of Tfr cell differentiation by KLF2 Mediated by KLF2 mediated Blipm1 and T-Bet expression [PDF]
Journal of Genetics and Molecular Biology, 2020 In normal circumstances, the germinal centre reaction (GC) in response to infectious agent results in production of antibodies (Ab) preventing aberrant inflammation and autoimmune diseases. In germinal centre the production of Ab is triggered by T follicular helper (Tfh) cells.
openaire +1 more source
Reversing Blood Flows Act through klf2a to Ensure Normal Valvulogenesis in the Developing Heart [PDF]
, 2009 Heart valve anomalies are some of the most common congenital heart defects, yet neither the genetic nor the epigenetic forces guiding heart valve development are well understood.
A. C Oates +60 more
core +5 more sources
The impact of KLF2 modulation on the transcriptional program and function of CD8 T cells.
PLoS ONE, 2013 Krüppel-like factor 2 (KLF2) is a transcription factor that is highly expressed in quiescent T lymphocytes and downregulated in effector T cells. We now show that antigen receptor engagement downregulates KLF2 expression in a graded response determined ...
Gavin C Preston +4 more
doaj +1 more source
Kruppel-Like Factor 2-Mediated Suppression of MicroRNA-155 Reduces the Proinflammatory Activation of Macrophages. [PDF]
PLoS ONE, 2015 Recent evidence indicates that significant interactions exist between Kruppel-like factor 2 (KLF2) and microRNAs (miRNAs) in endothelial cells. Because KLF2 is known to exert anti-inflammatory effects and inhibit the pro-inflammatory activation of ...
Shaolin He +3 more
doaj +1 more source
Tumor angiogenesis and anti-angiogenic therapy in malignant gliomas revisited [PDF]
, 2012 The cellular and molecular mechanisms of tumor angiogenesis and its prospects for anti-angiogenic cancer therapy are major issues in almost all current concepts of both cancer biology and targeted cancer therapy. Currently, (1) sprouting angiogenesis, (2)
Dumont, Daniel J. +2 more
core +1 more source
Transcriptional Regulation of Osteoclastogenesis: The Emerging Role of KLF2 [PDF]
Frontiers in Immunology, 2020 Dysregulation of osteoclastic differentiation and its activity is a hallmark of various musculoskeletal disease states. In this review, the complex molecular factors underlying osteoclastic differentiation and function are evaluated. The emerging role of KLF2 in regulation of osteoclastic differentiation is examined, specifically in the context of ...
Daniela Rolph, Hiranmoy Das
openaire +3 more sources
Human Amniocytes Are Receptive to Chemically Induced Reprogramming to Pluripotency [PDF]
, 2017 Restoring pluripotency using chemical compounds alone would be a major step forward in developing clinical-grade pluripotent stem cells, but this has not yet been reported in human cells.
Adjaye, J +15 more
core +4 more sources
Frontiers in Immunology, 2022 Krüppel-like factor 2 (KLF2) is a transcription factor with significant roles in development, maturation, differentiation, and proliferation of several cell types.
Nora Pernaa +18 more
doaj +1 more source
9aaTADs mimic DNA to interact with a pseudo-DNA Binding Domain KIX of Med15 (Molecular Chameleons) [PDF]
, 2009 The KIX-domain of Gal11/MED15 was shown to interact with short transactivation domain of Pdr1 and Oaf1 (12 and 9 amino acids respectively) annotated to 9aaTAD family.
martin piskacek
core +2 more sources