Results 51 to 60 of about 18,442 (279)
Krüppel-like factors in cancer progression: three fingers on the steering wheel [PDF]
, 2013 Kruppel-like factors (KLFs) comprise a highly conserved family of zinc finger transcription factors, that are involved in a plethora of cellular processes, ranging from proliferation and apoptosis to differentiation, migration and pluripotency.
de Beeck, Ken Op +4 more
core +3 more sources
Atherosusceptible Shear Stress Activates Endoplasmic Reticulum Stress to Promote Endothelial Inflammation. [PDF]
, 2017 Atherosclerosis impacts arteries where disturbed blood flow renders the endothelium susceptible to inflammation. Cytokine activation of endothelial cells (EC) upregulates VCAM-1 receptors that target monocyte recruitment to atherosusceptible regions ...
Bailey, Keith A +3 more
core +1 more source
Adipocyte, 2021 Extracellular vesicles (EVs) are nano-sized vesicles secreted actively by numeorus cells and have fundamental roles in intercellular communication through shuttling functional RNAs.
Zixin Hou +4 more
doaj +1 more source
Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension [PDF]
Nature Communications, 2020 Abstract Pulmonary arterial hypertension (PAH) is a severe disorder of lung vasculature that causes right heart failure. Homoeostatic effects of flow-activated transcription factor Krüppel-like factor 2 (KLF2) are compromised in PAH.
Hebah A. Sindi +17 more
openaire +10 more sources
Shear stress modulates endothelial KLF2 through activation of P2X4 [PDF]
Purinergic Signalling, 2015 Vascular endothelial cells that are in direct contact with blood flow are exposed to fluid shear stress and regulate vascular homeostasis. Studies report endothelial cells to release ATP in response to shear stress that in turn modulates cellular functions via P2 receptors with P2X4 mediating shear stress-induced calcium signaling and vasodilation.
Sathanoori, R +6 more
openaire +3 more sources
Role of noncoding RNA in vascular remodelling [PDF]
, 2016 Purpose of review: Noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are becoming fundamentally important in the pathophysiology relating to injury-induced vascular remodelling.
Baker, Andrew H. +2 more
core +1 more source
KLF2 mutation is the most frequent somatic change in splenic marginal zone lymphoma and identifies a subset with distinct genotype. [PDF]
, 2014 To characterise the genetics of splenic marginal zone lymphoma (SMZL), we performed whole exome sequencing of 16 cases and identified novel recurrent inactivating mutations in Kruppel-like factor 2 (KLF2), a gene whose deficiency was previously shown to ...
Ashton-Key, M +22 more
core +2 more sources
Kruppel-Like Factor 2 (KLF2) Regulates Endothelial Thrombotic Function [PDF]
Circulation Research, 2005 The vascular endothelium maintains blood fluidity by inhibiting blood coagulation, inhibiting platelet aggregation, and promoting fibrinolysis. Endothelial cells lose these nonthrombogenic properties on exposure to proinflammatory stimuli. We recently identified the Kruppel-like factor KLF2 as a novel regulator of endothelial proinflammatory activation.
Zhiyong, Lin +9 more
openaire +2 more sources
Co-expression networks in generation of induced pluripotent stem cells. [PDF]
, 2016 We developed an adenoviral vector, in which Yamanaka's four reprogramming factors (RFs) were controlled by individual CMV promoters in a single cassette (Ad-SOcMK). This permitted coordinated expression of RFs (SOX2, OCT3/4, c-MYC and KLF4) in a cell for
Coppola, Giovanni +6 more
core +2 more sources
Kaohsiung Journal of Medical Sciences, 2022 Oral squamous cell carcinoma (OSCC) is one of the most common carcinomas of the oral cavity. However, the regulatory mechanisms on miR‐32‐5p remain poorly understood in OSCC.
Shi‐Yu Qin +5 more
doaj +1 more source