Results 61 to 70 of about 18,442 (279)

Class IIa HDACs repressive activities on MEF2-depedent transcription are associated with poor prognosis of ER⁺ breast tumors. [PDF]

, 2013
MEF2s transcription factors and class IIa HDACs compose a fundamental axis for several differentiation pathways. Functional relationships between this axis and cancer are largely unexplored.
Brancolini, C., Clocchiatti, A, Di Giorgio, E, Ingrao, S, Meyer-Almes, FJ, Tripodo, C   +5 more
core   +1 more source

In Silico Modeling of Shear-Stress-Induced Nitric Oxide Production in Endothelial Cells through Systems Biology [PDF]

, 2012
Nitric oxide (NO) produced by vascular endothelial cells is a potent vasodilator and an antiinflammatory mediator. Regulating production of endothelial-derived NO is a complex undertaking, involving multiple signaling and genetic pathways that are ...
Ayyadurai, V. A. Shiva, Dewey, C. Forbes, Dewey, C. Forbes, Garcia-Cardena, Guillermo, Koo, Andrew Jia-An, Nordsletten, David, Umeton, Renato, Yankama, Beracah   +7 more
core   +1 more source

Regulation of β1 Integrin-Klf2-Mediated Angiogenesis by CCM Proteins [PDF]

Developmental Cell, 2015
Mechanotransduction pathways are activated in response to biophysical stimuli during the development or homeostasis of organs and tissues. In zebrafish, the blood-flow-sensitive transcription factor Klf2a promotes VEGF-dependent angiogenesis. However, the means by which the Klf2a mechanotransduction pathway is regulated to prevent continuous ...
Renz, Marc, Otten, Cécile, Faurobert, Eva, Rudolph, Franziska, Zhu, Yuan, Boulday, Gweńola, Duchene, Johan, Mickoleit, Michaela, Dietrich, Ann-Christin, Ramspacher, Caroline, Steed, Emily, Manet-Dupé, Sandra, Benz, Alexander, Hassel, David, Vermot, Julien, Huisken, Jan, Tournier-Lasserve, Elisabeth, Felbor, Ute, Sure, Ulrich, Albiges-Rizo, Corinne, Abdelilah-Seyfried, Salim   +20 more
openaire   +4 more sources

The expression of Kruppel-like factor 2 in mice with collagen-induced arthritis and its role in the induction of nitric oxide synthase production

European Journal of Inflammation, 2020
Kruppel-like factor 2 (KLF2) is associated with acute and chronic inflammation. However, the role of KLF2 in rheumatoid arthritis (RA) remains unknown.
Donglei Wu, Xinye Wang, Shuaijun Xu, Wanjun Zhang, Shiyi Zeng, Chenghong Ni, Xinjing Luo, Guoju Lv   +7 more
doaj   +1 more source

The effects of extracellular vesicles derived from Krüppel-Like Factor 2 overexpressing endothelial cells on the regulation of cardiac inflammation in the dilated cardiomyopathy

Journal of Nanobiotechnology, 2022
Background Dilated cardiomyopathy (DCM) is one of the common causes of heart failure. Myocardial injury triggers an inflammatory response and recruits immune cells into the heart. High expression of Krüppel-like factor 2 (KLF2) in endothelial cells (ECs)
Wenfeng Zhang, Ziwei Chen, Shuaihua Qiao, Siyuan Chen, Hongyan Zheng, Xuan Wei, Qiaoling Li, Biao Xu, Wei Huang   +8 more
doaj   +1 more source

Role of KLF2 in atrioventricular cushion development

The FASEB Journal, 2009
Krüppel like factors (KLFs) are transcription factors with important roles in development. KLF2 KO mice die by embryonic day 14.5 (E14.5) and exhibit heart failure and hemorrhaging. KLF2 is expressed in multiple tissues including erythroid and endothelial cells.
Jack L. Haar, Tina K. Lung, Aditi R. Chiplunkar, Joyce A. Lloyd   +3 more
openaire   +1 more source

Successful reprogramming of epiblast stem cells by blocking nuclear localization of β-catenin. [PDF]

, 2014
Epiblast stem cells (EpiSCs) in mice and rats are primed pluripotent stem cells (PSCs). They barely contribute to chimeric embryos when injected into blastocysts.
Hayama, Tomonari, Masaki, Hideki, Murayama, Hideyuki, Nakauchi, Hiromitsu, Sato, Hideyuki, Yamaguchi, Tomoyuki   +5 more
core   +2 more sources

Low-dose phloretin alleviates diabetic atherosclerosis through endothelial KLF2 restoration [PDF]

Bioscience, Biotechnology, and Biochemistry, 2020
ABSTRACT We investigated whether low-dose phloretin served as daily dietary supplements could ameliorate diabetic atherosclerosis and the role of kruppel-like factor 2 (KLF2). HUVECs cultured in high glucose medium were treated with different concentrations of phloretin and KLF2 mRNA, and protein level was detected.
Yong, Xia, Hua, Feng, Zhen-Wei, Li, Kuan-Xiao, Tang, Hai-Qing, Gao, Wei-Ling, Wang, Xiao-Pei, Cui, Xiao-Li, Li   +7 more
openaire   +2 more sources

Krüppel-like transcription factors KLF1 and KLF2 have unique and coordinate roles in regulating embryonic erythroid precursor maturation

Haematologica, 2014
The Krüppel-like transcription factors KLF1 and KLF2 are essential for embryonic erythropoiesis. They can partially compensate for each other during mouse development, and coordinately regulate numerous erythroid genes, including the β-like globins ...
Divya S. Vinjamur, Kristen J. Wade, Safa F. Mohamad, Jack L. Haar, Stephen T. Sawyer, Joyce A. Lloyd   +5 more
doaj   +1 more source

The shear stress-induced transcription factor KLF2 affects dynamics and angiopoietin-2 content of Weibel-Palade bodies. [PDF]

PLoS ONE, 2012
BACKGROUND: The shear-stress induced transcription factor KLF2 has been shown to induce an atheroprotective phenotype in endothelial cells (EC) that are exposed to prolonged laminar shear.
Ellen L van Agtmaal, Ruben Bierings, Bieuwke S Dragt, Thomas A Leyen, Mar Fernandez-Borja, Anton J G Horrevoets, Jan Voorberg   +6 more
doaj   +1 more source