Results 71 to 80 of about 18,442 (279)

Aberrant regulation of FBW7 in cancer [PDF]

, 2014
FBW7 (F-box and WD repeat domain-containing 7) or Fbxw7 is a tumor suppressor, which promotes the ubiquitination and subsequent degradation of numerous oncoproteins including Mcl-1, Cyclin E, Notch, c- Jun, and c-Myc.
Liu, Yueyong, Wang, Lixia, Wang, Zhiwei, Wei, Wenyi, Ye, Xiantao   +4 more
core   +1 more source

Neutrophil KLF2 Regulates Arterial and Venous Thrombosis

Blood, 2018
Abstract Experimental, clinical and pathological studies support an important link between inflammation and thrombosis. Although accumulating evidence suggests that cells of the innate immune system contribute to the thrombotic process, the identity of nodal molecular determinants operative in immune cells remains poorly understood.
Lalitha V. Nayak, Stephanie Lapping, Andrei Maiseyeu, Alvin H. Schmaier, Mukesh Jain   +4 more
openaire   +1 more source

Identification of the EBF1/ETS2/KLF2-miR-126-Gene Feed-Forward Loop in Breast Carcinogenesis and Stemness

International Journal of Molecular Sciences
MicroRNA (miR)-126 is frequently downregulated in malignancies, including breast cancer (BC). Despite its tumor-suppressive role, the mechanisms underlying miR-126 deregulation in BC remain elusive.
Alessandra Gambacurta, Valentina Tullio, Isabella Savini, A. Mauriello, M. Catani, V. Gasperi   +5 more
semanticscholar   +1 more source

IKKβ regulates endothelial thrombomodulin in a Klf2‐dependent manner [PDF]

Journal of Thrombosis and Haemostasis, 2014
Endothelial thrombomodulin (TM) is critically involved in anticoagulation, anti-inflammation, cytoprotection and normal fetal development. Tumor necrosis factor alpha (TNFα) suppresses TM expression.TNFα has been shown to down-regulate TM partly via activation of nuclear factor kappa B (NF-κB).
R, Pathak, L, Shao, S M, Chafekar, W, Feng, U, Ponnappan, L M, Fink, D, Zhou, M, Hauer-Jensen   +7 more
openaire   +2 more sources

Early loss of splenic Tfh cells in SIV-infected rhesus macaques [PDF]

, 2015
Follicular T helper cells (Tfh), a subset of CD4 T lymphocytes, provide crucial help to B cells in the production of antigen-specific antibodies. Although several studies have analyzed the dynamics of Tfh cells in peripheral blood and lymph nodes (LNs ...
Andreani, Guadalupe, Estaquier, Jérôme, Krust, Bernard, Laforge, Mireille, Moukambi, Félicien, Rabezanahary, Henintsoa, Racine, Gina, Robitaille, Lynda, Rodrigues, Vasco, Silvestre, Ricardo Jorge Leal, Soundaramourty, Calayselvy   +10 more
core   +7 more sources

KLF2 Inhibits the Migration and Invasion of Prostate Cancer Cells by Downregulating MMP2

American Journal of Men's Health, 2019
KLF2, a member of the Kruppel-like factor (KLF) family, is thought to be a tumor suppressor in many kinds of malignant tumors. Its functions in prostate cancer (PCa) are unknown.
Binshuai Wang, Mingyuan Liu, Yimeng Song, Changying Li, Shudong Zhang, Lulin Ma   +5 more
doaj   +1 more source

Suberanilohydroxamic Acid as a Pharmacological Kruppel‐Like Factor 2 Activator That Represses Vascular Inflammation and Atherosclerosis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundKruppel‐like factor 2 (KLF2) is an important zinc‐finger transcription factor that maintains endothelial homeostasis by its anti‐inflammatory, ‐thrombotic, ‐oxidative, and ‐proliferative effects in endothelial cells.
Yanni Xu, Suowen Xu, Peng Liu, Marina Koroleva, Shuya Zhang, Shuyi Si, Zheng Gen Jin   +6 more
doaj   +1 more source

miR‐92a‐3p promotes breast cancer proliferation by regulating the KLF2/BIRC5 axis

Thoracic Cancer, 2022
Background Breast cancer remains the most common malignancy in females around the world. Recently, a growing number of studies have focused on gene dysregulation.
Zhi‐Hao Yu, Zhao‐Hui Chen, Guang‐Lei Zhou, Xue‐Jie Zhou, Hai‐Yan Ma, Yue Yu, Xin Wang, Xu‐Chen Cao   +7 more
doaj   +1 more source

Krüppel-like factor 2 promotes liver steatosis through upregulation of CD36

Journal of Lipid Research, 2014
The Krppel-like factor (KLF) family of transcription factors regulates diverse biological processes that include proliferation, differentiation, apoptosis, development, and responses to external stress.
Jin-Lian Chen, Xiao-Jie Lu, Kai-Lin Zou, Kun Ye   +3 more
doaj   +1 more source

Blood flow modulation of vascular dynamics [PDF]

, 2015
Purpose of review: Blood flow is intimately linked with cardiovascular development, repair and dysfunction. The current review will build on the fluid mechanical principle underlying haemodynamic shear forces, mechanotransduction and metabolic effects.
Hsiai, Tzung K., Lee, Juhyun, Packard, René R. Sevag   +2 more
core   +1 more source