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Dissecting the KNDy Hypothesis: KNDy Neuron-Derived Kisspeptins Are Dispensable for Puberty but Essential for Preserved Female Fertility and Gonadotropin Pulsatility [PDF]

Metabolism: Clinical and Experimental, 2023
peer reviewed[en] BACKGROUND: Kiss1 neurons in the hypothalamic arcuate-nucleus (ARC) play key roles in the control of GnRH pulsatility and fertility. A fraction of ARC Kiss1 neurons, termed KNDy, co-express neurokinin B (NKB; encoded by Tac2). Yet, NKB-
Manuel Tena-Sempere, Encarnación Torres, Silvia León   +2 more
exaly   +9 more sources

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KNDy neuron as a gatekeeper of puberty onset

Journal of Obstetrics and Gynaecology Research, 2014
AbstractHypothalamo–pituitary–gonadal axis has been recognized as a functional unit orchestrating reproductive performance in mammals. The mechanism governing puberty onset, however, is still one of the great mysteries of biology. The present article reviews previous studies over the last century, which gradually elucidated the brain mechanism ...
Yoshihisa, Uenoyama, Hiroko, Tsukamura, Kei-ichiro, Maeda   +2 more
openaire   +2 more sources

KNDy Neurons Modulate the Magnitude of the Steroid-Induced Luteinizing Hormone Surges in Ovariectomized Rats [PDF]

Endocrinology, 2015
Kisspeptin is the most potent stimulator of LH release. There are two kisspeptin neuronal populations in the rodent brain: in the anteroventral periventricular nucleus (AVPV) and in the arcuate nucleus. The arcuate neurons coexpress kisspeptin, neurokinin B, and dynorphin and are called KNDy neurons. Because estradiol increases kisspeptin expression in
Richard Bertram, Janete Anselmo-Franci, Bruna Kalil   +2 more
exaly   +3 more sources

Cellular and Molecular Mechanisms Regulating the KNDy Neuronal Activities to Generate and Modulate GnRH Pulse in Mammals

Frontiers in Neuroendocrinology, 2022
Accumulating findings during the past decades have demonstrated that the hypothalamic arcuate kisspeptin neurons are supposed to be responsible for pulsatile release of gonadotropin-releasing hormone (GnRH) to regulate gametogenesis and steroidogenesis in mammals.
Naoko Inoue, Teppei Goto, Youki Watanabe
exaly   +3 more sources

KNDy innervation of MCH neurons modulates sleep in an estradiol-dependent manner

Physiology, 2023
Levels of circulating gonadal hormones, including estrogens, affect both subjective and objective measures of sleep quality. However, the mechanisms linking sex variables to sleep architecture are incompletely understood. One brain region known to be potently regulated by circulating levels of estradiol is the arcuate nucleus of the hypothalamus (ARH).
Bethany Beekly, Katherine Furman, Christian Burgess, Carol Elias   +3 more
openaire   +1 more source

Role of KNDy neurons in the negative-feedback suppression of gonadotropin secretion in female rats

Endocrinology
Abstract The hypothalamic neurons that coexpress kisspeptin, neurokinin B, and dynorphin (KNDy) play a crucial role in the control of gonadotropin-releasing hormone (GnRH) pulsatile release and, thereby, in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion.
Ana C Campideli-Santana, Kaoma S C Silva, Roberta Araujo-Lopes, Fernanda R C L Almeida, Jose Donato, Adelina M Reis, Raphael E Szawka   +6 more
openaire   +2 more sources

Establishment of immortalised cell lines derived from female Shiba goat KNDy and GnRH neurones

Journal of Neuroendocrinology, 2020
AbstractKisspeptin plays a critical role in governing gonadotrophin‐releasing hormone (GnRH)/gonadotrophin secretion and subsequent reproductive function in mammals. The hypothalamic arcuate nucleus (ARC) kisspeptin neurones, which co‐express neurokinin B (NKB) and dynorphin A (Dyn) and are referred to as KNDy neurones, are considered to be involved in
Yuta Suetomi, Ryoki Tatebayashi, Shuhei Sonoda, Arisa Munetomo, Shuichi Matsuyama, Naoko Inoue, Yoshihisa Uenoyama, Yukari Takeuchi, Hiroko Tsukamura, Satoshi Ohkura, Fuko Matsuda   +10 more
openaire   +2 more sources

Neurokinin receptor antagonists for vasomotor symptoms: from KNDy neurons to clinical translation

Nature Reviews Endocrinology
Vasomotor symptoms (VMS), including hot flushes and night sweats, affect approximately 70% of people experiencing menopause and have a notable effect on quality of life. Until the past few years, the underlying neuroendocrine mechanisms remained poorly understood, limiting therapeutic options beyond menopausal hormone therapy.
Encarnación Torres, Ellen G. Wall, Víctor M. Navarro   +2 more
openaire   +2 more sources

The Interaction of Fasting, Caloric Restriction, and Diet-Induced Obesity With 17β-Estradiol on the Expression of KNDy Neuropeptides and Their Receptors in the Female Mouse

Molecular and Cellular Endocrinology, 2016
Arcuate neurons that coexpress kisspeptin (Kiss1), neurokinin B (Tac2), and dynorphin (Pdyn) mediate negative feedback of 17β-estradiol (E2) on the HPG axis.
Troy Roepke, Ali Yasrebi, Jennifer A Yang   +2 more
exaly   +1 more source

Eu-estrogenemia, KNDy Neurons, and Vasomotor Symptoms

JAMA Internal Medicine, 2015
Irwin J, Kerber, Ralph J, Turner
openaire   +2 more sources