Results 41 to 50 of about 2,060,910 (365)
Proceedings of the National Academy of Sciences of the United States of America, 2001 We previously reported the disruption of the murine gene encoding the transcription factor USF2 and its consequences on glucose-dependent gene regulation in the liver.
G. Nicolas +6 more
semanticscholar +1 more source
Effect of the social environment on olfaction and social skills in WT and mouse model of autism [PDF]
arXiv, 2023 Autism spectrum disorders are complex, polygenic and heterogenous neurodevelopmental conditions, imposing a substantial economic burden. Genetics are influenced by the environment, specifically the social experience during the critical neurodevelopmental period.
arxiv
Establishment and identification of a mouse model of Fscb/Cabyr double gene knockout
Di-san junyi daxue xuebao, 2020 Objective To construct a mouse model of targeted knockout of Fscb/Cabyr dual genes by using the CRISPR/Cas9 system, in order to found a basis for the study of the role of FSCB and CABYR protein complexe in sperm flagellum movement and capacitation ...
LI Zhongtai +3 more
doaj +1 more source
Transgenic mice: beyond the knockout [PDF]
American Journal of Physiology-Renal Physiology, 2011 Transgenic mice have had a tremendous impact on biomedical research. Most researchers are familiar with transgenic mice that carry Cre recombinase (Cre) and how they are used to create conditional knockouts. However, some researchers are less familiar with many of the other types of transgenic mice and their applications.
openaire +3 more sources
Knockout mice as experimental models of virulence [PDF]
Medical Mycology, 2000 Infection models with animals whose immune systems have been selectively altered by neutralization of endogenous cytokines or by deletion of a gene have provided a valuable means to study the function of cells or cytokines in the context of complex multidimensional interactions.
DEEPE G. S. J.R. +6 more
openaire +4 more sources
mGluR5 Knockout mice exhibit normal conditioned place-preference to cocaine [PDF]
, 2012 Metabotropic glutamate receptor 5 (mGluR5) null mutant (-/-) mice have been reported to totally lack the rein- forcing or locomotor stimulating effects of cocaine. We tested mGluR5 -/- and +/+ mice for their locomotor and conditioned place- preference response to cocaine.
arxiv +1 more source
Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis
Cell Research, 2013 Mixed lineage kinase domain-like protein (Mlkl) was recently found to interact with receptor interacting protein 3 (Rip3) and to be essential for tumor necrosis factor (TNF)-induced programmed necrosis (necroptosis) in cultured cell lines.
Jianfeng Wu +13 more
semanticscholar +1 more source
Production of Knockout Mice using CRISPR/Cas9 in FVB Strain
Journal of Animal Reproduction and Biotechnology, 2015 KO mice provide an excellent tool to determine roles of specific genes in biomedical filed. Traditionally, knockout mice were generated by homologous recombination in embryonic stem cells.
Hee Sook Bae, Soo Jin Lee , Ok Jae Koo
doaj +1 more source
Antioxidants, 2022 Selenoprotein F (SELENOF) might play an important role in maintaining human health since an increasing number of studies have linked SELENOF deficiency to various pathologies such as cancer and neurodegeneration.
Min Li, Yun Zhang, Jun Zhou, Hongmei Liu
doaj +1 more source
ODBAE: a high-performance model identifying complex phenotypes in high-dimensional biological datasets [PDF]
arXiv, 2022 Identifying complex phenotypes from high-dimensional biological data is challenging due to the intricate interdependencies among different physiological indicators. Traditional approaches often focus on detecting outliers in single variables, overlooking the broader network of interactions that contribute to phenotype emergence.
arxiv