Results 41 to 50 of about 773,972 (346)

Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour [PDF]

open access: yes, 2016
The five-subunit WASH complex generates actin networks that participate in endocytic trafficking, migration and invasion in various cell types. Loss of one of the two subunits WASH or strumpellin in mice is lethal, but little is known about their role in
Insall, Robert H.   +5 more
core   +1 more source

Selenoprotein F Knockout Caused Glucose Metabolism Disorder in Young Mice by Disrupting Redox Homeostasis

open access: yesAntioxidants, 2022
Selenoprotein F (SELENOF) might play an important role in maintaining human health since an increasing number of studies have linked SELENOF deficiency to various pathologies such as cancer and neurodegeneration.
Min Li, Yun Zhang, Jun Zhou, Hongmei Liu
doaj   +1 more source

Ovol2, a zinc finger transcription factor, is dispensable for spermatogenesis in mice

open access: yesReproductive Biology and Endocrinology, 2019
Ovol2, a mouse homolog of Drosophila ovo, was identified as a zinc finger transcription factor predominantly expressed in testis. However, the function of Ovol2 in postnatal male germ cell development remains enigmatic. Here, we firstly examined the mRNA
Jin Zhang   +6 more
doaj   +1 more source

The NADPH Oxidase Isoform 1 Contributes to Angiotensin II-Mediated DNA Damage in the Kidney

open access: yesAntioxidants, 2020
In higher concentrations, the blood pressure regulating hormone angiotensin II leads to vasoconstriction, hypertension, and oxidative stress by activating NADPH oxidases which are a major enzymatic source of reactive oxygen species (ROS).
Anna Zimnol   +4 more
doaj   +1 more source

Knockout of the 15 kDa selenoprotein protects against chemically-induced aberrant crypt formation in mice. [PDF]

open access: yesPLoS ONE, 2012
Evidence suggests that selenium has cancer preventive properties that are largely mediated through selenoproteins. Our previous observations demonstrated that targeted down-regulation of the 15 kDa selenoprotein (Sep15) in murine colon cancer cells ...
Petra A Tsuji   +8 more
doaj   +1 more source

Purkinje cell-specific Grip1/2 knockout mice show increased repetitive self-grooming and enhanced mGluR5 signaling in cerebellum [PDF]

open access: yes, 2019
Cerebellar Purkinje cell (PC) loss is a consistent pathological finding in autism. However, neural mechanisms of PC-dysfunction in autism remain poorly characterized.
Chiu, Shu-Ling   +6 more
core   +1 more source

Pdgfrα-Cre mediated knockout of the aryl hydrocarbon receptor protects mice from high-fat diet induced obesity and hepatic steatosis.

open access: yesPLoS ONE, 2020
Aryl hydrocarbon receptor (AHR) agonists such as dioxin have been associated with obesity and the development of diabetes. Whole-body Ahr knockout mice on high-fat diet (HFD) have been shown to resist obesity and hepatic steatosis.
Francoise A Gourronc   +9 more
doaj   +1 more source

PexRAP inhibits PRDM16-mediated thermogenic gene expression [PDF]

open access: yes, 2017
How the nuclear receptor PPARγ regulates the development of two functionally distinct types of adipose tissue, brown and white fat, as well as the browning of white fat, remains unclear.
Dean, John M   +8 more
core   +3 more sources

Lack of Inducible Nitric Oxide Synthase Prevents Lipid-Induced Skeletal Muscle Insulin Resistance Without Attenuating Cytokine Level

open access: yesJournal of Pharmacological Sciences, 2011
.: We examined whether deletion of inducible nitric oxide synthase (iNOS) could prevent lipid infusion-induced insulin resistance in iNOS-knockout and wild-type mice with the in vivo euglycemic-hyperinsulinemic clamp technique. Plasma NO metabolites were
Hye-Na Cha   +5 more
doaj   +1 more source

Double Deletion of Angiotensin II Type 2 and Mas Receptors Accelerates Aging‐Related Muscle Weakness in Male Mice

open access: yesJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background The activation of AT2 (angiotensin II type 2 receptor ) and Mas receptor by angiotensin II and angiotensin‐(1‐7), respectively, is the primary process that counteracts activation of the canonical renin‐angiotensin system (RAS).
Hikari Takeshita   +14 more
doaj   +1 more source

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