Downregulation of KLF8 expression by shRNA induces inhibition of cell proliferation in CAL27 human oral cancer cells [PDF]
, 2013 Objectives: KLF8 is a member of KLF transcription factors which play an important tolr in oncogenesis. It is barely expressed in normal human epithelial cells but highly overexpressed in several types of human cancer cell lines.
Bin, Zhang +7 more
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Krüppel-like factor 4 transcriptionally regulates TGF-β1 and contributes to cardiac myofibroblast differentiation. [PDF]
PLoS ONE, 2013 Angiotensin II (Ang II) plays a major role in the pathogenesis of cardiac fibrosis in hypertension. It is known that Ang II induces TGF-β1 expression.
Yi Zhang +5 more
doaj +1 more source
An iPSC-derived vascular model of Marfan syndrome identifies key mediators of smooth muscle cell death. [PDF]
, 2016 Marfan syndrome (MFS) is a heritable connective tissue disorder caused by mutations in FBN1, which encodes the extracellular matrix protein fibrillin-1.
Bernard, William George +6 more
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Genetic and Epigenetic Inactivation of Kruppel-like Factor 4 in Medulloblastoma
Neoplasia: An International Journal for Oncology Research, 2010 Although medulloblastoma is the most common pediatric malignant brain tumor, its molecular underpinnings are largely unknown. We have identified rare, recurrent homozygous deletions of Kruppel-like Factor 4 (KLF4) in medulloblastoma using high-resolution
Yukiko Nakahara +14 more
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コッカクケイ サイボウ ニ オケル テンシャ インシ Krüppel-Like Factor 4 ノ サヨウ カイセキ [PDF]
Material from: 'Fujikawa, J., Tanaka, M., Itoh, S., et al., Kruppel-like factor 4 expression in osteoblasts represses osteoblast-dependent osteoclast maturation, Cell and Tissue Research, published 2014, Springer ...
フジカワ, ジュンジ +1 more
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The cell fate determinant Llgl1 influences HSC fitness and prognosis in AML [PDF]
, 2013 A unique characteristic of hematopoietic stem cells (HSCs) is the ability to self-renew. Several genes and signaling pathways control the fine balance between self-renewal and differentiation in HSCs and potentially also in leukemia stem cells. Recently,
Armstrong, Scott A. +11 more
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Journal of Neuroinflammation, 2010 Background Activation of microglia, the resident macrophages of the central nervous system (CNS), is the hallmark of neuroinflammation in neurodegenerative diseases and other pathological conditions associated with CNS infection.
Das Sulagna +3 more
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Identifizierung potentieller Zielgene des Transkriptionsfaktors Sp3 in vitro und in vivo [PDF]
, 2004 Der ubiquitär vorkommende Transkriptionsfaktor Sp3 (Specificity protein) sowie Sp1, Sp2 und Sp4 gehören zu einer Protein-Familie, die an Sequenzen auf der DNA wie die GC-Box oder die GT-Box binden.
Schmidt, Gabriele +1 more
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A novel role of Krüppel-like factor 4 in Zhikong scallop Chlamys farreri during spermatogenesis. [PDF]
PLoS ONE, 2017 Krüppel-like factor 4 (KLF4) is a kind of zinc finger transcription factor, which is involved in terminal differentiation of epithelial cells and reprogramming of somatic cells to induced pluripotent stem (iPS) cells in mammals.
Dandan Yang +5 more
doaj +1 more source
PACAP neuropeptide promotes Hepatocellular Protection via CREB-KLF4 dependent autophagy in mouse liver Ischemia Reperfusion Injury. [PDF]
, 2020 Organ ischemia reperfusion injury (IRI), associated with acute hepatocyte death, remains an unresolved problem in clinical orthotopic liver transplantation (OLT).
Busuttil, Ronald W +9 more
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