Results 91 to 100 of about 3,537 (198)

Acanthamoeba castellanii–Mediated Reduction of Interleukin‐1β Secretion and Its Association With Macrophage Autophagy

Scientifica, Volume 2025, Issue 1, 2025.
Noncanonical autophagy including unconventional protein secretion has been extensively studied. Our work focused on a leaderless IL‐1β protein secretion from human macrophage in response to Acanthamoeba castellanii components, Acanthamoeba culture supernatant (CS) and cell lysate (CL), as well as its association with macrophage autophagy.
Rachasak Boonhok, Wilaiwan Senghoi, Suthinee Sangkanu, Chooi Ling Lim, Matsayapan Pudla, Maria de Lourdes Pereira, Polrat Wilairatana, Tooba Mahboob, Md. Atiar Rahman, Pongsak Utaisincharoen, Poonsit Hiransai, Veeranoot Nissapatorn, Simone Carradori   +12 more
wiley   +1 more source

Kratom safety and toxicology in the public health context: research needs to better inform regulation

Frontiers in Pharmacology
Although kratom use has been part of life for centuries in Southeast Asia, the availability and use of kratom in the United States (US) increased substantially since the early 2000s when there was little information on kratom pharmacology, use patterns ...
Jack E. Henningfield, Jack E. Henningfield, Oliver Grundmann, Marilyn A. Huestis, Kirsten E. Smith   +4 more
doaj   +1 more source

Drug-Induced Liver Injury Caused by Kratom Use as an Alternative Pain Treatment Amid an Ongoing Opioid Epidemic

Journal of Investigative Medicine High Impact Case Reports, 2019
Kratom ( Mitragyna speciosa ) is a prevalent medicinal plant used mainly for the stimulant and analgesic properties provided through multiple alkaloid compounds.
Caroline Stokes Osborne MD, Amanda N. Overstreet DO, Don C. Rockey MD, Andrew D. Schreiner MD, MSCR   +3 more
doaj   +1 more source

In Vitro Antioxidant Properties of Mitratonic Remedy in Tea Form and In Vivo Protection Against Methanol‐Induced Oxidative Stress in Wistar Rats

Scientifica, Volume 2025, Issue 1, 2025.
Natural healthcare products with antiaging properties are attracting growing interest, and Thailand has a rich tradition of using herbal remedies for disease treatment and overall well‐being. Mitra tea, derived from the traditional Mitratonic Remedy, is a Thai herbal formulation that has been used by local traditional healers for over 20 years and is ...
Acharaporn Issuriya, Sineenart Sanpinit, Surasak Limsuwan, Jo Aan Goon, Palika Wetchakul, Raghuram Kandimalla   +5 more
wiley   +1 more source

Antipyretic effect of crude methanolic extract of Mytragyna speciosa in mice. [PDF]

, 2011
Mitragyna speciosa is a species of tropical indigenous plant that can be found mainly in Southeast Asia. This study aims to ascertain the existence of antipyretic properties of the crude methanolic extract of Mitragynaspeciosa, and determine its ...
Abdul Kadir, Arifah, Salleh, Annas, Shaik Mossadeq, Wan Mastura   +2 more
core  

Methoxetamine-related deaths in the UK : an overview [PDF]

, 2015
Objective: The goal of this study is to provide an update on the data given on methoxetamine (MXE)-related fatalities that occurred in 2011–2013, presented at the Second International Conference on Novel Psychoactive Substances.
Anand, Ayres, Corazza, Hamilton, Hill, Hydzik, Kjellgren, Morgan, Rosenbaum, Schifano, Schmidt, Shields, Westwell, Wikström, Wood, Wood, Yiu-Cheung, Łukasik-Głebocka   +17 more
core   +1 more source

Development and validation of a quantitative method for the analysis of delta‐9‐tetrahydrocannabinol (delta‐9‐THC), delta‐8‐tetrahydrocannabinol (delta‐8‐THC), delta‐9‐tetrahydrocannabinolic acid (THCA), and cannabidiol (CBD) in botanicals, edibles, liquids, oils, waxes, and bath products by gas chromatography mass spectrometry (GC/MS)

Journal of Forensic Sciences, Volume 69, Issue 5, Page 1718-1729, September 2024.
Abstract A quantitative gas chromatography mass spectrometry (GC/MS) method was developed for delta‐9‐tetrahydrocannabinol (delta‐9‐THC), delta‐8‐tetrahydrocannabinol (delta‐8‐THC), tetrahydrocannabinolic acid (THCA), and cannabidiol (CBD) in matrices including plant material, liquids and oils, waxes, edibles, and bath and body products.
Sarah A. Shuda, Joshua F. Folger, Erin Spargo, Barry K. Logan   +3 more
wiley   +1 more source

The challenge of synthetic drugs in East and South-East Asia and Oceania [PDF]

The demand for synthetic drugs in East and Southeast Asia and Oceania continues to rise, while rapid economic integration is creating new opportunities for transnational criminal groups to expand the illicit drug trade, warns the United Nations Office on
Justice Tettey
core  

Kratom (Mitragynine) Ingestion Requiring Naloxone Reversal

Clinical Practice and Cases in Emergency Medicine, 2019
Kratom (mitragynine) is a naturally occurring opioid agonist whose use has been escalating. Its suppliers advertise it as a safe alternative for opioids and a safe treatment for opioid-withdrawal symptoms. There has been controversy in the past two years
Daniel L. Overbeek, Jonathan Abraham, Brendan W. Munzer   +2 more
doaj   +1 more source

Knowledge will Propel Machine Understanding of Content: Extrapolating from Current Examples

, 2017
Machine Learning has been a big success story during the AI resurgence. One particular stand out success relates to learning from a massive amount of data.
Anantharam Pramod, Anantharam Pramod, Balasuriya Lakshika, Ferrucci David, Kimmig Angelika, McMahon Connor, Meng Lingling, Perera Sujan, Sheth Amit, Wijeratne Sanjaya, Wijeratne Sanjaya   +10 more
core   +1 more source