Results 71 to 80 of about 4,369 (260)

The Intrinsic Role Of Endoplasmic Reticulum Stress Sensors In The Mechanism Underlying The Depressive Symptoms And Kratom Dependence In Chronic Kratom Users [PDF]

, 2023
Background: This study aimed to determine the differences in the mRNA and protein expression of ER stress sensors (such as BiP, XBP1, ATF4 and CHOP) in the peripheral blood mononuclear cells (PBMCs) between non-drug using healthy controls and regular ...
Fauzi, Nurul Atiqah Muhamad
core   +1 more source

Evaluating the Pattern of Kava (Piper methysticum) Consumption in Australia by Wastewater‐Based Epidemiology

Drug and Alcohol Review, Volume 45, Issue 6, September 2026.
The process for estimating kava consumption using wastewater analysis. ABSTRACT Introduction Kava (Piper methysticum) is a plant native to the Pacific Islands, used in the preparation of a beverage consumed during ceremonies. The plant has gained popularity in other countries as a supplement for the treatment of anxiety and insomnia.
Lorato Makanye, Emma L. Keller, Cobus Gerber, Bradley S. Simpson   +3 more
wiley   +1 more source

Sosialisasi Mahasiswa Universitas Tanjungpura Terhadap Isu Kratom (Mitragyna Speciosa) Global

Jurnal Pengabdian Multidisiplin
Kegiatan pengabdian pada mahasiswa Universitas Tanjungpura (UNTAN) berupa pendampingan dalam memberikan pengetahuan dan keterampilan keamanan konsumsi Kratom agar memenuhi syarat kesehatan.
Sulvi Purwayantie, Sholahuddin, Nur Endah Saputri, Suko Priyono   +3 more
doaj   +1 more source

Dual anti-inflammatory activities of COX-2/5-LOX driven by kratom alkaloid extracts in lipopolysaccharide-induced RAW 264.7 cells

Scientific Reports
Cyclooxygenase (COX) and lipoxygenase (LOX) enzymes play a pivotal role in producing pro-inflammatory eicosanoids, including prostaglandins (PGs) and leukotrienes (LTs), in the inflammation process.
S. I. Rahmawati, D. W. Indriani, Febby Nurdiya Ningsih, Mutia Hardhiyuna, Firdayani Firdayani, Peni Ahmadi, A'Liyatur Rosyidah, Eris Septiana, Ni Luh Putu Indi Dharmayanti, A. Bayu, M. Putra   +10 more
semanticscholar   +1 more source

Liver Injury Associated with Kratom, A Popular Opioid-Like Product: Experience from the U.S. Drug Induced liver Injury Network [PDF]

, 2021
Background: Kratom is a botanical product used as an opium substitute with abuse potential. Methods: Assessment of suspected cases of kratom-induced liver injury in a prospective US cohort. Results: Eleven cases of liver injury attributed to kratom
Odin, Joseph A., Fontana, Robert J., Vuppalanchi, Raj, Barnhart, Huiman, Hayashi, Paul H., Conjeevaram, Hari, Ahmad, Jawad, Navarro, Victor J., Avula, Bharathi, Khan, Ikhlas A., Drug-Induced Liver Injury Network, Joseph A Odin, Hari Conjeevaram, Jawad Ahmad, Huiman Barnhart, Paul H Hayashi, Bharathi Avula, Victor J Navarro, Raj Vuppalanchi, Robert J Fontana, Ikhlas A Khan   +20 more
core   +1 more source

Defining kratom: evidence-based policy guidelines for a rapidly evolving market

Frontiers in Pharmacology
The leaves of Mitragyna speciosa, commonly called kratom, have been consumed for centuries in Southeast Asia for their energizing and analgesic properties.
Erin Berthold, Paula N. Brown, Paula N. Brown, Michael Chan, Oliver Grundmann, Christopher R. McCurdy, Christopher R. McCurdy, Abhisheak Sharma, Darshan Singh   +8 more
doaj   +1 more source

Gastroprotective effects of methanolic extract of kratom leaves on gastric ulcer and reflux esophagitis in rats [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2018
Kratom (Mitragyna speciosa (Korth.) Havil.) is a tropical tree indigenous to Thailand. In traditional medicine, it has been used to treat diarrhea, peptic ulcer, stomach ache or gastric upsets.
Somsmorn Chittrakarn, Nisaudah Radenahmad, Sujitra Kaewsara, Wandee Udomuksorn, Niwat Keawpradub, Pimpimol Phukpattaranont   +5 more
doaj   +1 more source

Enzymatic epimerization of monoterpene indole alkaloids in Kratom

Nature Chemical Biology
Monoterpene indole alkaloids (MIAs) are a large, structurally diverse class of bioactive natural products. These compounds are biosynthetically derived from a stereoselective Pictet–Spengler condensation that generates a tetrahydro-β-carboline scaffold ...
Allwin McDonald, Yoko Nakamura, C. Schotte, G. Titchiner, Kin H Lau, Ryan M. Alam, A. A. Lopes, C. Buell, S. O'Connor   +8 more
semanticscholar   +1 more source

Brief report: Meth, tranq, gas station heroin & other drugs complicating addiction treatment

The American Journal on Addictions, Volume 35, Issue 4, Page 543-546, July 2026.
Abstract Background and Objectives Patients using fentanyl have worse treatment outcomes; however, little is known about other drugs that complicate treatment. Methods A national survey (n = 396) was conducted using a random sample of clinicians waivered to prescribe buprenorphine in the United States.
Erin L. Winstanley, Jane M. Liebschutz, Cristina Murray‐Krezan, Galen E. Switzer, Samantha Nash, Sarah Kawasaki   +5 more
wiley   +1 more source

How Salmonella Works Under Osmotic and Desiccation Stresses

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.
ABSTRACT Salmonella remains one of the leading threats in foods with reduced water activity, where it can survive for long periods and cause outbreaks. Its persistence stems from a wide array of adaptive strategies shaped by the selective pressures imposed by low‐moisture foods.
Mayara Messias Oliveira, Dionisio P. Amorim‐Neto, Anderson S. Sant'Ana   +2 more
wiley   +1 more source