Dystrophinopathy-associated dysfunction of Krebs cycle metabolism. [PDF]
Hum Mol Genet, 2019 Duchenne muscular dystrophy is a deadly muscle-wasting disorder caused by loss of dystrophin protein. Studies suggest that metabolic alterations are important to disease pathogenesis. Because muscle accounts for ~40% of body mass, we hypothesized that dystrophy-mediated metabolic changes would be measurable in biofluids and that a metabolomic analysis ...
Lindsay A +4 more
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The Krebs Cycle Connection: Reciprocal Influence Between Alternative Splicing Programs and Cell Metabolism [PDF]
Frontiers in Oncology, 2018 Alternative splicing is a pervasive mechanism that molds the transcriptome to meet cell and organism needs. However, how this layer of gene expression regulation is coordinated with other aspects of the cell metabolism is still largely undefined. Glucose
Giuseppe Biamonti +2 more
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The Impact of Krebs Cycle Intermediates on the Endocrine System and Immune System: A Comparison [PDF]
Endocrines, 2023 Introduction: The Krebs cycle is an important set of reactions that synthesize different molecules and substances that affect various organs. The objective of this paper was to compare the effects of Krebs cycle intermediates on the endocrine system and ...
Borros M. Arneth
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Robustness of the Krebs Cycle under Physiological Conditions and in Cancer: New Clues for Evaluating Metabolism-Modifying Drug Therapies [PDF]
Biomedicines, 2022 The Krebs cycle in cells that contain mitochondria is necessary for both energy production and anabolic processes. In given cell/condition, the Krebs cycle is dynamic but remains at a steady state.
Rafael Franco, Joan Serrano-Marín
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A cyanosulfidic origin of the Krebs cycle. [PDF]
Sci Adv, 2021 All four cellular subsystems can be provided under compatible prebiotic conditions.
Ritson DJ.
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Lithium salts of Krebs cycle substrates as potential normothymic antioxidant agents
Journal of Pharmacy and Bioallied Sciences, 2018 Objective: Aim of the present work was to study the antioxidant properties of lithium salts of Krebs cycle substrates and their influence on immune cells. Lithium is a well-known and widely used mood stabilizer.
Evgenii Plotnikov +2 more
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An amino acid mixture, enriched with Krebs cycle intermediates, enhances extracellular matrix gene expression in cultured human fibroblasts. [PDF]
Amino Acids, 2023 Ragni M +5 more
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Ketamine exerts a protective role in a cell-based model of major depressive disorder via the inhibition of apoptosis and inflammation and activation of the Krebs cycle [PDF]
Biomolecules & Biomedicine, 2020 Major depressive disorder (MDD) is one of the most common psychiatric disorders characterized by major depressive episodes. Although great efforts have been made to develop antidepressant drugs that target the monoaminergic system, these drugs are ...
Wenfei Zhang +3 more
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Retinal metabolism displays evidence for uncoupling of glycolysis and oxidative phosphorylation via Cori-, Cahill-, and mini-Krebs-cycle [PDF]
eLifeThe retina consumes massive amounts of energy, yet its metabolism and substrate exploitation remain poorly understood. Here, we used a murine explant model to manipulate retinal energy metabolism under entirely controlled conditions and utilised 1H-NMR ...
Yiyi Chen +8 more
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Krebs Cycle Moonlights in Caspase Regulation. [PDF]
Dev Cell, 2016 In this issue of Developmental Cell, Aram et al. (2016) identify a mechanism that uses a Krebs cycle protein to control local activation of a ubiquitin ligase complex at the mitochondrial outer membrane for temporally and spatially restricted caspase activation during Drosophila sperm differentiation.
Minis A, Steller H.
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