Accumulation of Succinate in Cardiac Ischemia Primarily Occurs via Canonical Krebs Cycle Activity [PDF]
Cell Reports, 2018 Succinate accumulates during ischemia, and its oxidation at reperfusion drives injury. The mechanism of ischemic succinate accumulation is controversial and is proposed to involve reversal of mitochondrial complex II.
Jimmy Zhang +5 more
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Engineering of Escherichia coli for Krebs cycle-dependent production of malic acid [PDF]
Microbial Cell Factories, 2018 Background Malate is a C4-dicarboxylic acid widely used as an acidulant in the food and beverage industry. Rational engineering has been performed in the past for the development of microbial strains capable of efficient production of this metabolite ...
Debora Trichez +8 more
doaj +3 more sources
Plasma Krebs Cycle Intermediates in Nonalcoholic Fatty Liver Disease. [PDF]
J Clin Med, 2020 Nonalcoholic liver disease (NAFLD) is manifested with a wide spectrum of clinical symptoms and is closely associated with the metabolic syndrome, inflammation, and mitochondrial dysfunction. Although the mechanism of mitochondrial dysfunction in NAFLD is
Sandlers Y +5 more
europepmc +4 more sources
A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation. [PDF]
Front Immunol, 2018 Metabolism in immune cells is no longer thought of as merely a process for adenosine triphosphate (ATP) production, biosynthesis, and catabolism. The reprogramming of metabolic pathways upon activation is also for the production of metabolites that can ...
Williams NC, O'Neill LAJ.
europepmc +4 more sources
GPR91: expanding the frontiers of Krebs cycle intermediates. [PDF]
Cell Commun Signal, 2016 Since it was discovered, the citric acid cycle has been known to be central to cell metabolism and energy homeostasis. Mainly found in the mitochondrial matrix, some of the intermediates of the Krebs cycle are also present in the blood stream. Currently, there are several reports that indicate functional roles for Krebs intermediates out of its cycle ...
de Castro Fonseca M +4 more
europepmc +6 more sources
Alternol eliminates excessive ATP production by disturbing Krebs cycle in prostate cancer. [PDF]
Prostate, 2019 Alternol is a natural compound isolated from fermentation products of a mutant fungus. Our previous studies demonstrated that Alternol specifically kills cancer cells but spares benign cells.
Li C +12 more
europepmc +4 more sources
Air pollution-derived particulate matter dysregulates hepatic Krebs cycle, glucose and lipid metabolism in mice. [PDF]
Sci Rep, 2019 Exposure to ambient air particulate matter (PM2.5) is well established as a risk factor for cardiovascular and pulmonary disease. Both epidemiologic and controlled exposure studies in humans and animals have demonstrated an association between air ...
Reyes-Caballero H +11 more
europepmc +4 more sources
Queueing theory model of Krebs cycle
Bioinformatics, 2021 AbstractMotivationQueueing theory can be effective in simulating biochemical reactions taking place in living cells, and the article paves a step toward development of a comprehensive model of cell metabolism. Such a model could help to accelerate and reduce costs for developing and testing investigational drugs reducing number of laboratory animals ...
Sylwester Kloska +7 more
openaire +3 more sources
Hydrogen Drives Part of the Reverse Krebs Cycle under Metal or Meteorite Catalysis. [PDF]
Angew Chem Int Ed Engl, 2022 Hydrogen (H2) is a geological source of reducing electrons that is thought to have powered the metabolism of the last universal common ancestor to all extant life, and that is still metabolized by various modern organisms.
Rauscher SA, Moran J.
europepmc +2 more sources
Thin Layer Chromatography of KREBS Cycle Acids [PDF]
Clinical Chemistry and Laboratory Medicine, 2009 A systematic appraisal of a large number of solvent systems was carried out for the separation of lactic, pyruvic and 3-hydroxybutyric acids and all of the KREBS cycle acids, except oxalosuccinic, using silica gel G and cellulose thin layer Chromatographie plates.
KRAIKER, H. P., BURCH, R. E.
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