Results 21 to 30 of about 46,456 (156)

The role of itaconate in host defense and inflammation

The Journal of Clinical Investigation, 2022
Macrophages exposed to inflammatory stimuli including LPS undergo metabolic reprogramming to facilitate macrophage effector function. This metabolic reprogramming supports phagocytic function, cytokine release, and ROS production that are critical to ...
Christian G. Peace, Luke A.J. O’Neill
doaj   +1 more source

Queueing theory model of Krebs cycle

Bioinformatics, 2021
AbstractMotivationQueueing theory can be effective in simulating biochemical reactions taking place in living cells, and the article paves a step toward development of a comprehensive model of cell metabolism. Such a model could help to accelerate and reduce costs for developing and testing investigational drugs reducing number of laboratory animals ...
Sylwester Kloska, Krzysztof Pałczyński, Tomasz Marciniak, Tomasz Talaśka, Marissa Nitz, Beata J Wysocki, Paul Davis, Tadeusz A Wysocki   +7 more
openaire   +2 more sources

Fluxomics of the Eastern Oyster for Environmental Stress Studies

Metabolites, 2014
The metabolism of 2-13C/15N-glycine and U-13C-glucose was determined in four tissue blocks (adductor muscle, stomach and digestive gland, mantle, and gills) of the Eastern oyster (Crassostrea virginica) using proton (1H) and carbon-13 (13C) nuclear ...
Andrey P. Tikunov, Michael K. Stoskopf, Jeffrey M. Macdonald   +2 more
doaj   +1 more source

Metabolite changes in conifer buds and needles during forced bud break in Norway spruce (Picea abies) and European silver fir (Abies alba)

Frontiers in Plant Science, 2014
Environmental changes such as early spring and warm spells induce bud burst and photosynthetic processes in cold-acclimated coniferous trees and consequently, cellular metabolism in overwintering needles and buds.
Priyanka eDhuli, Jens eRohloff, G. Richard eStrimbeck   +2 more
doaj   +1 more source

Mitochondrial aconitase suppresses immunity by modulating oxaloacetate and the mitochondrial unfolded protein response

Nature Communications, 2023
Accumulating evidence indicates that mitochondria play crucial roles in immunity. However, the role of the mitochondrial Krebs cycle in immunity remains largely unknown, in particular at the organism level.
Eunah Kim, Andrea Annibal, Yujin Lee, Hae-Eun H. Park, Seokjin Ham, Dae-Eun Jeong, Younghun Kim, Sangsoon Park, Sujeong Kwon, Yoonji Jung, JiSoo Park, Sieun S. Kim, Adam Antebi, Seung-Jae V. Lee   +13 more
doaj   +1 more source

Enzyme expression in indica and japonica rice cultivars under saline stress - doi: 10.4025/actascibiolsci.v34i4.8535

Acta Scientiarum: Biological Sciences, 2012
The southern State of Rio Grande do Sul (RS) is the main rice producer in Brazil with a 60% participation of the national production and 86% participation of the region. Rice culture irrigation system is done by flooding, which leads to soil salinization,
Maria da Graça de Souza Lima, Nei Fernandes Lopes, Paulo Dejalma Zimmer, Geri Eduardo Meneghello, Cristina Rodrigues Mendes, Luciano do Amarante   +5 more
doaj   +1 more source

Metabolic Reprogramming—A New Era How to Prevent and Treat Graft Versus Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation Has Begun

Frontiers in Pharmacology, 2020
Allogeneic hematopoietic stem cell transplantation (HSCT) is the solitary therapeutic therapy for many types of hematological cancers. The benefits of this procedure are challenged by graft vs.
Reena Kumari, Senthilnathan Palaniyandi, Gerhard C. Hildebrandt   +2 more
doaj   +1 more source

Inhibition of Malate Dehydrogenase-2 Protects Renal Tubular Epithelial Cells from Anoxia-Reoxygenation-Induced Death or Senescence

Biomolecules, 2022
Ischemia-reperfusion injury is the leading cause of acute kidney injury. Reactive oxygen species (ROS) production causes cell death or senescence. In cultures of primary human renal tubular epithelial cells (RPTECs) subjected to anoxia-reoxygenation ...
Theodoros Eleftheriadis, Georgios Pissas, Spyridon Golfinopoulos, Maria Efthymiadi, Vassilios Liakopoulos, Ioannis Stefanidis   +5 more
doaj   +1 more source

The metabolism of aged seeds. The involvement of the pentose phosphate pathway in respiration in germinating rye grains of various ages

Acta Societatis Botanicorum Poloniae, 2014
Winter rye grains from different harvest years (having distinctly different viabilities) were studied in terms of germination, total dehydrogenase activity and growth analysis.
Kazimierz Zalewski
doaj   +1 more source

Development of the therapeutic regimen based on the synergistic activity of cyclophosphamide and double-stranded DNA preparation which results in complete cure of mice engrafted with Krebs-2 ascites

Вавиловский журнал генетики и селекции, 2016
Cumulative evidence obtained in this series of studies has guided the logic behind the development of a novel composite dsDNA-based preparation whose therapeutic application according to the specific regimen completely cures the mice engrafted with ...
E. A. Potter, E. V. Dolgova, A. S. Proskurina, Ya. R. Efremov, O. S. Taranov, V. P. Nikolin, N. A. Popova, T. D. Dubatolova, D. D. Petrova, E. I. Vereschagin, A. M. Minkevich, O. M. Andrushkevich, S. I. Baiborodin, V. A. Rogachev, A. A. Ostanin, E. R. Chernykh, N. A. Kolchanov, S. S. Bogachev   +17 more
doaj   +1 more source