Results 21 to 30 of about 3,153,249 (347)

Krebs cycle anions in metabolic acidosis. [PDF]

Critical care (London, England), 2005
For many years it has been apparent from estimates of the anion gap and the strong ion gap that anions of unknown identity can be generated in sepsis and shock states. Evidence is emerging that at least some of these are intermediates of the citric acid cycle.
Bowling, Francis G, Morgan, Thomas J
openaire   +3 more sources

Mitochondrial Probe Methyltriphenylphosphonium (TPMP) Inhibits the Krebs Cycle Enzyme 2-Oxoglutarate Dehydrogenase. [PDF]

PLoS ONE, 2016
Methyltriphenylphosphonium (TPMP) salts have been widely used to measure the mitochondrial membrane potential and the triphenylphosphonium (TPP+) moiety has been attached to many bioactive compounds including antioxidants to target them into mitochondria
Moustafa Elkalaf, Petr Tůma, Martin Weiszenstein, Jan Polák, Jan Trnka   +4 more
doaj   +2 more sources

Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis. [PDF]

Cell Metab, 2021
Wang YP, Sharda A, Xu SN, van Gastel N, Man CH, Choi U, Leong WZ, Li X, Scadden DT.   +8 more
europepmc   +2 more sources

A plausible metal-free ancestral analogue of the Krebs cycle composed entirely of α-ketoacids. [PDF]

Nat Chem, 2020
Efforts to decipher the prebiotic roots of metabolic pathways have focused on recapitulating modern biological transformations, with metals typically serving in place of cofactors and enzymes.
Stubbs RT, Yadav M, Krishnamurthy R, Springsteen G.   +3 more
europepmc   +2 more sources

The Efficiency of the Krebs Cycle and the Respiratory Chain in Physiologically and Prematurely Aging Bees (<i>Apis mellifera</i>). [PDF]

Int J Mol Sci
Kunat-Budzyńska M, Staniszewska P, Olszewski K, Cytryńska M, Strachecka A.   +4 more
europepmc   +3 more sources

Application of a novel nanoemulsion adjuvant for rabies vaccine which stabilizes a Krebs cycle intermediate (SDH) in an animal model. [PDF]

Hum Vaccin Immunother, 2019
Ze L, Zonglin L, Ya'Nan W, Shaohui S, Huijuan Y, Wei C, Li W, Liao G.   +7 more
europepmc   +3 more sources

Coupling Krebs cycle metabolites to signalling in immunity and cancer. [PDF]

Nat Metab, 2019
Ryan DG, Murphy MP, Frezza C, Prag HA, Chouchani ET, O'Neill LA, Mills EL.   +6 more
europepmc   +2 more sources

Metabolic Outcomes of Anaplerotic Dodecanedioic Acid Supplementation in Very Long Chain Acyl-CoA Dehydrogenase (VLCAD) Deficient Fibroblasts

Metabolites, 2021
Very long-chain acyl-CoA dehydrogenase deficiency (VLCADD, OMIM 609575) is associated with energy deficiency and mitochondrial dysfunction and may lead to rhabdomyolysis and cardiomyopathy.
Igor Radzikh, Erica Fatica, Jillian Kodger, Rohan Shah, Ryan Pearce, Yana I. Sandlers   +5 more
doaj   +1 more source

Succinate and succinate dehydrogenase as a «foothold» in the Krebs cycle in critical conditions

Антибиотики и Химиотерапия, 2023
Purpose. Search and presentation of data from experimental and clinical studies reflecting the central role of succinate and succinate dehydrogenase in the regulation of adaptation mechanisms in critical conditions. Material and methods.
Yu. P. Orlov, A. V. Butrov, S. V. Sviridov, V. V. Afanasiev, A. N. Kondratiev, L. M. Tsentsiper, N. V. Govorova, A. I. Kondratiev, G. A. Baytugaeva, E. N. Kakulya   +9 more
doaj   +1 more source

Metals promote sequences of the reverse Krebs cycle. [PDF]

Nat Ecol Evol, 2017
The reverse tricarboxylic acid (rTCA) cycle (also known as the reverse Krebs cycle) is a central anabolic biochemical pathway whose origins are proposed to trace back to geochemistry, long before the advent of enzymes, RNA or cells, and whose imprint ...
Muchowska KB, Varma SJ, Chevallot-Beroux E, Lethuillier-Karl L, Li G, Moran J.   +5 more
europepmc   +2 more sources