Results 51 to 60 of about 46,456 (156)

The Succinated Proteome of FH-Mutant Tumours

Metabolites, 2014
Inherited mutations in the Krebs cycle enzyme fumarate hydratase (FH) predispose to hereditary leiomyomatosis and renal cell cancer (HLRCC). Loss of FH activity in HLRCC tumours causes accumulation of the Krebs cycle intermediate fumarate to high levels,
Ming Yang, Nicola Ternette, Huizhong Su, Raliat Dabiri, Benedikt M. Kessler, Julie Adam, Bin Tean Teh, Patrick J. Pollard   +7 more
doaj   +1 more source

Hydrogen Drives Part of the Reverse Krebs Cycle under Metal or Meteorite Catalysis. [PDF]

Angew Chem Int Ed Engl, 2022
Rauscher SA, Moran J.
europepmc   +1 more source

Changes in energetic metabolism of Biomphalaria glabrata (Mollusca, Planorbidae) in response to exogenous calcium

Brazilian Journal of Biology
Calcium is considered an essential element for the metabolism of aquatic snail Biomphalaria glabrata (Say, 1818), intermediate host of Schistosoma mansoni Sambon, 1907 in Brazil, and represents a limiting factor to its distribution and adaptation to the ...
L. D. Silva, V. C. S. Amaral, M. C. Vinaud, A. M. Castro, H. H. A. Rezende, D. B. Santos, C. C. Mello-Silva, J. C. B. Bezerra   +7 more
doaj   +1 more source

Metabolic Signature of Dietary Iron Overload in a Mouse Model

Cells, 2018
Iron is an essential co-factor for several metabolic processes, including the Krebs cycle and mitochondrial oxidative phosphorylation. Therefore, maintaining an appropriate iron balance is essential to ensure sufficient energy production and to avoid ...
Chiara Volani, Giuseppe Paglia, Sigurdur V. Smarason, Peter P. Pramstaller, Egon Demetz, Christa Pfeifhofer-Obermair, Guenter Weiss   +6 more
doaj   +1 more source

The Key Enzymes of Carbon Metabolism and the Glutathione Antioxidant System Protect Yarrowia lipolytica Yeast Against pH-Induced Stress

Journal of Fungi
In this study, we first thoroughly assayed the response of the key enzymes of energy metabolism and the antioxidant system in Yarrowia lipolytica yeast at extreme pH.
Tatyana I. Rakhmanova, Natalia N. Gessler, Elena P. Isakova, Olga I. Klein, Yulia I. Deryabina, Tatyana N. Popova   +5 more
doaj   +1 more source

An amino acid mixture, enriched with Krebs cycle intermediates, enhances extracellular matrix gene expression in cultured human fibroblasts. [PDF]

Amino Acids, 2023
Ragni M, Canciani L, Spataro L, Ruocco C, Valerio A, Nisoli E.   +5 more
europepmc   +1 more source

Mitochondrial Ultrastructure and Activity Are Differentially Regulated by Glycolysis-, Krebs Cycle-, and Microbiota-Derived Metabolites in Monocytes. [PDF]

Biology (Basel), 2022
Pérez-Hernández CA, Moreno-Altamirano MMB, López-Villegas EO, Butkeviciute E, Ali M, Kronsteiner B, Dunachie SJ, Dockrell HM, Smith SG, Sánchez-García FJ.   +9 more
europepmc   +1 more source

Targeting Krebs-cycle-deficient renal cell carcinoma with Poly ADP-ribose polymerase inhibitors and low-dose alkylating chemotherapy. [PDF]

Oncotarget, 2022
Ueno D, Vasquez JC, Sule A, Liang J, van Doorn J, Sundaram R, Friedman S, Caliliw R, Ohtake S, Bao X, Li J, Ye H, Boyd K, Huang RR, Dodson J, Boutros P, Bindra RS, Shuch B.   +17 more
europepmc   +1 more source

“Reversed” Krebs Cycle Can Feed Tumors [PDF]

Cancer Discovery, 2012
Abstract Certain cancer cells that have mutations preventing them from using the normal oxidative pathway of the Krebs cycle can ramp up the withdrawal of various intermediates from the Krebs cycle to churn out macromolecular precursors essential for rapid cell growth.
openaire   +1 more source

Metabolic flux from the Krebs cycle to glutamate transmission tunes a neural brake on seizure onset. [PDF]

PLoS Genet, 2021
Jeong J, Lee J, Kim JH, Lim C.
europepmc   +1 more source