Results 61 to 70 of about 46,456 (156)

Combining PEGylated mito-atovaquone with MCT and Krebs cycle redox inhibitors as a potential strategy to abrogate tumor cell proliferation. [PDF]

Sci Rep, 2022
Cheng G, Hardy M, You M, Kalyanaraman B.
europepmc   +1 more source

Mitochondrial Dysfunction and Reduced TCA Cycle Metabolite Levels in Inflammatory Bowel Disease Patients

Journal of Inflammation Research
Ewa Dudzińska,1 Agnieszka Madro,2 Ann Katrin Sauer,3,4 Andreas M Grabrucker,3– 5 Aneta Strachecka6 1Department of Dietetics and Nutrition Education, Medical University of Lublin, Lublin, Poland; 2Department of Gastroenterology with Endoscopic Unit,
Dudzińska E, Madro A, Sauer AK, Grabrucker AM, Strachecka A   +4 more
doaj  

Metabolomic profiling of pheochromocytomas in dogs: Catecholamine phenotype and tricarboxylic acid cycle metabolites

Journal of Veterinary Internal Medicine
Background In humans with pheochromocytomas (PCCs), targeted metabolomics is used to determine the catecholamine phenotype or to uncover underlying pathogenic variants in tricarboxylic acid (TCA) cycle genes such as succinate dehydrogenase subunits (SDHx)
Marit F. van denBerg, Nicole Bechmann, Hans S. Kooistra, Monique E. vanWolferen, Elpetra P. M. Timmermans‐Sprang, Mirko Peitzsch, Sara Galac   +6 more
doaj   +1 more source

Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis. [PDF]

Cell Metab, 2021
Wang YP, Sharda A, Xu SN, van Gastel N, Man CH, Choi U, Leong WZ, Li X, Scadden DT.   +8 more
europepmc   +1 more source

Glutamate-Induced Deregulation of Krebs Cycle in Mitochondrial Encephalopathy Lactic Acidosis Syndrome Stroke-Like Episodes (MELAS) Syndrome Is Alleviated by Ketone Body Exposure. [PDF]

Biomedicines, 2022
Belal S, Goudenège D, Bocca C, Dumont F, Chao De La Barca JM, Desquiret-Dumas V, Gueguen N, Geffroy G, Benyahia R, Kane S, Khiati S, Bris C, Aranyi T, Stockholm D, Inisan A, Renaud A, Barth M, Simard G, Reynier P, Letournel F, Lenaers G, Bonneau D, Chevrollier A, Procaccio V.   +23 more
europepmc   +1 more source

Mitochondrial respiratory chain and Krebs cycle enzyme function in human donor livers subjected to end-ischaemic hypothermic machine perfusion. [PDF]

PLoS One, 2021
Abudhaise H, Taanman JW, DeMuylder P, Fuller B, Davidson BR.   +4 more
europepmc   +1 more source

Glutaminase inhibitor CB-839 causes metabolic adjustments in colorectal cancer cells

Scientific Reports
Colorectal cancer (CRC) cells are ‘addicted’ to glutamine to satisfy energy and biosynthetic needs. Inhibiting glutamine metabolism enzymes, like glutaminase, is a potential cancer therapy strategy. Although the GLS inhibitor CB-839 is being evaluated in
Martina Spada, Cristina Piras, Vera Piera Leoni, Mattia Casula, Gabriella Simbula, Antonio Noto, Katia Lilliu, Karolina Krystyna Kopeć, Gabriele Serreli, Federica Murgia, Federica Etzi, Tinuccia Dettori, Luigi Atzori, Paola Caria   +13 more
doaj   +1 more source

Exploring neuropsychiatric manifestations of vitamin B complex deficiencies

Frontiers in Psychiatry
B complex vitamins, a group of eight water-soluble vitamins, play interconnected roles in maintaining nervous system health. Thiamine (B1), riboflavin (B2), and niacin (B3) are essential as co-enzymes in numerous metabolic reactions related to energy ...
Anamaria Han, Leandro Almeida, Nikhilesh Anand, Ihsan M. Salloum, Ihsan M. Salloum, Salim Kanaan, Salim Kanaan, Bharathi S. Gadad, Bharathi S. Gadad, João Paulo Lima Daher, João Paulo Lima Daher   +10 more
doaj   +1 more source

A plausible metal-free ancestral analogue of the Krebs cycle composed entirely of α-ketoacids. [PDF]

Nat Chem, 2020
Stubbs RT, Yadav M, Krishnamurthy R, Springsteen G.   +3 more
europepmc   +1 more source

Plasma Krebs Cycle Intermediates in Nonalcoholic Fatty Liver Disease. [PDF]

J Clin Med, 2020
Sandlers Y, Shah RR, Pearce RW, Dasarathy J, McCullough AJ, Dasarathy S.   +5 more
europepmc   +1 more source