Aglycemic HepG2 Cells Switch From Aminotransferase Glutaminolytic Pathway of Pyruvate Utilization to Complete Krebs Cycle at Hypoxia. [PDF]
Front Endocrinol (Lausanne), 2018 Human hepatocellular carcinoma HepG2 cells are forced to oxidative phosphorylation (OXPHOS), when cultured in aglycemic conditions at galactose and glutamine.
Ježek J, Plecitá-Hlavatá L, Ježek P.
europepmc +2 more sources
Microbial Cell, 2019 Iron is an essential nutrient for immune cells and microbes, therefore the control of its homeostasis plays a decisive role for infections. Moreover, iron affects metabolic pathways by modulating the translational expression of the key tricarboxylic acid
Julia Telser +6 more
doaj +1 more source
Potential therapeutic use of the ketogenic diet in autism spectrum disorders. [PDF]
, 2014 The ketogenic diet (KGD) has been recognized as an effective treatment for individuals with glucose transporter 1 (GLUT1) and pyruvate dehydrogenase (PDH) deficiencies as well as with epilepsy.
Dueñas, Nadia +2 more
core +1 more source
Plants, 2023 Protein phosphatase 2A (PP2A) is a heterotrimeric conserved serine/threonine phosphatase complex that includes catalytic, scaffolding, and regulatory subunits.
Ahmed Elshobaky +3 more
doaj +1 more source
Upregulation of Krebs cycle and anaerobic glycolysis activity early after onset of liver ischemia. [PDF]
PLoS One, 2018 The liver is a highly vascularized organ receiving a dual input of oxygenated blood from the hepatic artery and portal vein. The impact of decreased blood flow on glucose metabolism and how hepatocytes could adapt to this restrictive environment are ...
Chan TS +9 more
europepmc +2 more sources
A spatial analysis of physiological changes associated with infection of cotyledons of marrow plants with cucumber mosaic virus [PDF]
, 1996 Changes in host primary metabolism associated with the compatible interaction between cucumber mosaic virus and cotyledons of the marrow plant (Cucurbita pepo L.) have been localized, first by measuring activities of key enzymes in infected and ...
Leegood, R.C. +3 more
core +3 more sources
Lactate concentration gradient from right atrium to pulmonary artery: a commentary [PDF]
, 2005 Inadequate myocardial performance is a common complication of severe sepsis. Studies in humans strongly argue against a decrease in coronary blood flow in the pathogenesis of this sepsis-induced cardiac injury.
Creteur, Jacques
core +2 more sources
Mechanistic Information and Causal Continuity [PDF]
, 2010 Some biological processes (our examples are DNA expression and a reflex response in the leech) move from step to step in a way that cannot be completely understood solely in terms of causes and correlations.
Bogen, Jim, Machamer, Peter
core
A study of the effects of exercise on the urinary metabolome using normalisation to individual metabolic output [PDF]
, 2015 Aerobic exercise, in spite of its multi-organ benefit and potent effect on the metabolome, has yet to be investigated comprehensively via an untargeted metabolomics technology.
Anthony, Nahoum +5 more
core +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source