Results 81 to 90 of about 3,153,249 (347)

Evaluating the Antiviral Efficacy of Encapsulated PKC Inhibitor BIM‐I against influenza A Virus Infection

Advanced Healthcare Materials, EarlyView.
This study explores nanoparticle delivery of the protein kinase C inhibitor bisindolylmaleimide‐I (BIM‐I) to combat influenza A virus infections. Encapsulation in biodegradable PLGA nanoparticles improved safety while maintaining the compound's strong antiviral activity.
Laura Klement, Jana Ismail, Josefine Schroeder, Amod Godbole, Johanna Schreiber, Christine Weber, Zoltan Cseresnyes, Marc T. Figge, Bettina Löffler, Ulrich S. Schubert, Stephanie Schubert, Christina Ehrhardt, Carsten Hoffmann   +12 more
wiley   +1 more source

Stomatal control of leaf fluxes of carbonyl sulfide and CO₂ in a Typha freshwater marsh [PDF]

, 2017
Carbonyl sulfide (COS) is an emerging tracer to constrain land photosynthesis at canopy to global scales, because leaf COS and CO2 uptake processes are linked through stomatal diffusion.
C. Lett, C. Lett, K. Maseyk, K. Maseyk, U. Seibt, U. Seibt, W. Sun   +6 more
core   +4 more sources

Fabrication, Properties, and Applications of Scaffolds for Bone Tissue Regeneration

Advanced Materials Technologies, EarlyView.
This review explores cutting‐edge biomaterials and fabrication techniques for scaffolds in bone tissue regeneration. It conducts a critical comparison of various strategies, meticulously analyzes the key contradictions in the field, and outlines an integrated development path spanning from biomaterial selection to clinical application, while ...
Shangsi Chen, Min Wang
wiley   +1 more source

A Broken Krebs Cycle in Macrophages [PDF]

Immunity, 2015
Macrophages undergo metabolic rewiring during polarization but details of this process are unclear. In this issue of Immunity, Jha et al. (2015) report a systems approach for unbiased analysis of cellular metabolism that reveals key metabolites and metabolic pathways required for distinct macrophage polarization states.
openaire   +2 more sources

Subleading contributions to the nuclear scalar isoscalar currents

, 2020
We extend our recent analyses of the nuclear vector, axial-vector and pseudoscalar currents and derive the leading one-loop corrections to the two-nucleon scalar current operator in the framework of chiral effective field theory using the method of ...
Epelbaum, Evgeny, Krebs, Hermann, Meißner, Ulf-G.   +2 more
core   +1 more source

Investigating A Dose Response Relationship between High Fat Diet Consumption and the Contractile Performance of Isolated Mouse Soleus, EDL and Diaphragm Muscles [PDF]

, 2019
PurposeRecent evidence has demonstrated an obesity-induced, skeletal muscle-specific reduction in contractile performance. The extent and magnitude of these changes in relation to total dose of high-fat diet consumption remains unclear.
A Abdelmoula, A Matsakas, A Wronska, BH Goodpaster, C Barclay, C Barclay, Cameron Hill, CJ Blimkie, CJ Tanner, D Akhmedov, D Pette, D Tomlinson, DM D’Souza, DS Ward, F Zurlo, FR Paolillo, H Eshima, J Aucouturier, J Ciapaite, J Kemp, J Machann, J Mendez, J Szymura, J Tallis, J Tallis, J Tallis, J Tallis, J Tallis, J Wilde de, Jason Tallis, JD Altringham, JD Bruton, Josh Hurst, KE Shortreed, KE Trajcevski, M Hulens, MA Brotto, MM Thomas, MS Denies, N Miyatake, NA Maffiuletti, NA Maffiuletti, P Capodaglio, P Kopelman, P Rogers, R Singh, RK Josephson, RK Josephson, Rob S. James, RS James, RS James, RS James, S Warmington, SR Anderson, Val M. Cox, Y Rolland, Y Yoshida   +56 more
core   +1 more source

Krebs Cycle Intermediates Protective against Oxidative Stress by Modulating the Level of Reactive Oxygen Species in Neuronal HT22 Cells

Antioxidants, 2017
Krebs cycle intermediates (KCIs) are reported to function as energy substrates in mitochondria and to exert antioxidants effects on the brain. The present study was designed to identify which KCIs are effective neuroprotective compounds against oxidative
Kenta Sawa, Takumi Uematsu, Y. Korenaga, Ryuya Hirasawa, M. Kikuchi, Kyohei Murata, Jian Zhang, Xiaoqing Gai, K. Sakamoto, T. Koyama, T. Satoh   +10 more
semanticscholar   +1 more source

Long‐Term Effects of Xenotransplantation of Human Enteric Glia in an Immunocompetent Rat Model of Acute Brain Injury

Advanced Science, EarlyView.
Acute brain injuries are characterized by extensive tissue damage, resulting in debilitating deficits in patients. Despite considerable progress, cell‐based approaches have yet to identify an ideal candidate. This long‐term study explores the use of an untested cell source – human enteric glia – and a non‐invasive administration route – intranasal ...
Nina Colitti, Edwige Rice, Franck Desmoulin, Maylis Combeau, Mélissa Parny, Lorenne Robert, Etienne Buscail, Barbara Bournet, Nathalie Vergnolle, Isabelle Raymond‐Letron, Isabelle Loubinoux, Carla Cirillo   +11 more
wiley   +1 more source

Alpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations

Nature Communications, 2020
α-ketoglutarate is an intermediate of the Krebs Cycle that was recently reported to extend lifespan in C.Elegans. Here, the authors show that administration of α-ketoglutarate to mice reduces age-related bone loss, by ameliorating senescence of bone ...
Yuan Wang, Peng Deng, Yuting Liu, Yunshu Wu, Yaqian Chen, Yuchen Guo, Shiwen Zhang, Xiaofei Zheng, Liyan Zhou, Weiqing Liu, Qiwen Li, Weimin Lin, Xingying Qi, Guomin Ou, Cunyu Wang, Quan Yuan   +15 more
doaj   +1 more source

Optically monitored nuclear spin dynamics in individual GaAs quantum dots grown by droplet epitaxy

, 2008
We report optical orientation experiments in individual, strain free GaAs quantum dots in AlGaAs grown by droplet epitaxy. Circularly polarized optical excitation yields strong circular polarization of the resulting photoluminescence at 4K.
A. Abragam, A. Malinowski, Bernhard Urbaszek, Claire-Marie Simon, Kazuaki Sakoda, Nobuyuki Koguchi, Takaaki Mano, Takashi Kuroda, Thierry Amand, Thomas Belhadj, V. Kalevich, Xavier Marie   +11 more
core   +1 more source