Results 31 to 40 of about 4,169 (220)

Determining Laboratory Reference Values of TREC and KREC in Different Age Groups of Iranian Healthy Individuals

Iranian Journal of Allergy, Asthma and Immunology, 2019
Assessment of the number of T-cell receptor excision circles (TREC) and kappa-deleting recombination excision circles (KREC) copies has been recently described as biomarkers of newly formed T and B cells respectively.
Leila Shakerian, Zahra Pourpak, Somayeh Shamlou, Erna Domsgen, Anoshirvan Kazemnejad, Hossein Dalili, Maryam Nourizadeh   +6 more
doaj   +3 more sources

Monitoring of Immune Recovery After Hematopoietic Stem Cell Transplantation in Patients with Aplastic Anemia by Quantitative Determination of TREC and KREC

Journal of Human Immunity
Analysis of T- and B-lymphocyte recovery after hematopoietic stem cell transplantation (HSCT) is important for assessing the positive dynamics of treatment. Flow cytometry is informative enough to monitor immune recovery in the post-transplant period.
E. Polyakova, Tatyana Shman, Yulia Mareika, M. Belevtsev   +3 more
semanticscholar   +2 more sources

Quantitative Analysis of TREC and KREC Molecules in Patients with Acute Lymphoblastic Leukemia at the Stage of Maintenance Therapy

Journal of Human Immunity
Maintenance therapy (MT), which aims to destroy the remaining tumor cells after hematopoietic stem cell transplantation (HSCT), is the final stage of treatment for acute lymphoblastic leukemia (ALL).
E. Polyakova, Tatyana Shman, Yulia Mareika, Dmitry Tsekhanovich, I. Pakhomava, I. Guryanova, T. Volodashchik, Krystina Veratsennik, M. Belevtsev, Anzhelika Solntsava   +9 more
semanticscholar   +2 more sources

Diagnostic significance of determining TREC and KREC T- and B-cell receptor rearrangement products in patients with inborn immune errors

Proceedings of the National Academy of Sciences of Belarus Medical series, 2023
Inborn immunity errors such as primary immunodeficiencies in children represent a significant problem for public health, and it is undeniably important to improve the laboratory diagnosis of this pathology by creating new, effective methods for early ...
Евгения Александровна Полякова, М.В. Стёганцева, И. Е. Гурьянова, Д.В. Луцкович, Е.Я. Скоповец, А.В. Любушкин, Т. П. Володащик, В. И. Казак, Ю. В. Скибо, М.В. Белевцев, E. Polyakova, M. Stegantseva, I. Guryanova, Dmitry V. Lutskovich, K. Skapavets, A. V. Liubushkin, T. Volodashchik, Victoria I. Kazak, Yulia V. Skibo, M. V. Belevtsev   +19 more
semanticscholar   +3 more sources

Prospective Study of a Cohort of Russian Nijmegen Breakage Syndrome Patients Demonstrating Predictive Value of Low Kappa-Deleting Recombination Excision Circle (KREC) Numbers and Beneficial Effect of Hematopoietic Stem Cell Transplantation (HSCT) [PDF]

Frontiers in Immunology, 2017
BackgroundNijmegen breakage syndrome (NBS) is a combined primary immunodeficiency with DNA repair defect, microcephaly, and other phenotypical features.
Elena Deripapa, Dmitry Balashov, Yulia Rodina, Alexandra Laberko, Natalya Myakova, Nataliia V. Davydova, Nataliia V. Davydova, Maria A. Gordukova, Dmitrii S. Abramov, Galina V. Pay, Larisa Shelikhova, Andrey P. Prodeus, Andrey P. Prodeus, Mikhail A. Maschan, Alexey A. Maschan, Anna Shcherbina   +15 more
doaj   +2 more sources

Quantitative indicators of TREC and KREC excision circles in malignancies: a prospective cohort study

Journal of Modern Oncology
Background. In oncology, of particular interest is the study of the T-cell receptor excision circles (TREC) and the κ-deletion B-cell receptor excision circles (KREC), which are extrachromosomal DNA structures.
A. Sultanbaev, Shamil I. Musin, K. Menshikov, N. Sultanbaeva, I. Tuzankina, D. Lipatov, I. A. Menshikova, M. Sultanbaev, Dmitry A. Kudlay, A. Prodeus   +9 more
semanticscholar   +3 more sources

Diagnostic significance of determining products of DNA rearrangments of the T-and-B cell receptor TREC/KREC in common variable immunodeficiency

Medical and Biological Problems of Life Activity
Common variable immunedeficiency (CVID) is a group of diseases that are inborn errors of the immune system and are characterized by impaired production of protective antibodies. The reason is a defect in the T- and B-cells, leading to impaired ability to
E. Polyakova, I. Guryanova, S. Sharapova, I. Sakovich, M. Shitikova, A. Kupchinskaya, Т. P. Volodashchik, Y. V. Tsimokhava, N. Aheyeu, S. Aleshkevich, Y. Zharankova, A. V. Solntsava, M. V. Belevtsev   +12 more
semanticscholar   +3 more sources

Diagnostic value of TREC and KREC for detecting immune disorders in newborns

Allergology and Immunology in Pediatrics, 2022
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L. Y. Barycheva, L. S. Khachirova, V. A. Firsova, S. Yu. Farsiiants   +3 more
openalex   +4 more sources

Recombination Excision Circle (KREC) Immunoglobulin Gene Rearrangement Mechamism and Importance in Transplants [PDF]

Turkish Journal of Immunology, 2021
Zeynep Akbulut, Gülderen Yanıkkaya Demirel   +1 more
openalex   +2 more sources

Harmonizing TREC Thresholds in Newborn Screening for SCID: Insights From Russian Validation Cohort. [PDF]

J Clin Lab Anal
Refining TREC cutoff values in newborn screening (NBS) for SCID: ROC analysis of a large testing cohort supports increasing the TREC threshold from 100 to 150–200 copies/105 cells, improving assay sensitivity and enabling earlier detection of SCID and other immunodeficiencies.
Marakhonov A, Kalinina E, Larin S, Khadzhieva M, Dudina E, Mukhina A, Rodina Y, Efimova I, Balinova N, Sermyagina I, Shchagina O, Zinchenko R, Voronin S, Shcherbina A, Kutsev S.   +14 more
europepmc   +2 more sources