Results 31 to 40 of about 4,018 (199)

99P Quantitative indicators of TREC and KREC excision rings in malignant neoplasms

ESMO Open, 2023
A.V. Sultanbaev, S. Musin, K. Menshikov, N. Sultanbaevа, I. Menshikova, A. Fatikhova, M. Sultanbaev, V. E. Askarov, D. Kudlay   +8 more
openalex   +2 more sources

Quantitative Analysis of TREC and KREC Molecules in Patients with Acute Lymphoblastic Leukemia at the Stage of Maintenance Therapy

Journal of Human Immunity
Maintenance therapy (MT), which aims to destroy the remaining tumor cells after hematopoietic stem cell transplantation (HSCT), is the final stage of treatment for acute lymphoblastic leukemia (ALL).
Ekaterina Polyakova, Т. В. Шман, Yulia Mareika, Dmitry Tsekhanovich, Iryna V. Pakhomava, Irina Guryanova, Tatiana Volodashchik, Krystina Veratsennik, Mikhail Belevtsev, A. V. Solntsava   +9 more
openalex   +2 more sources

Harmonizing TREC Thresholds in Newborn Screening for SCID: Insights From Russian Validation Cohort. [PDF]

J Clin Lab Anal
Refining TREC cutoff values in newborn screening (NBS) for SCID: ROC analysis of a large testing cohort supports increasing the TREC threshold from 100 to 150–200 copies/105 cells, improving assay sensitivity and enabling earlier detection of SCID and other immunodeficiencies.
Marakhonov A, Kalinina E, Larin S, Khadzhieva M, Dudina E, Mukhina A, Rodina Y, Efimova I, Balinova N, Sermyagina I, Shchagina O, Zinchenko R, Voronin S, Shcherbina A, Kutsev S.   +14 more
europepmc   +2 more sources

A minimal physiologically-based pharmacokinetic modeling platform to predict intratumor exposure and receptor occupancy of an anti-LAG-3 monoclonal antibody. [PDF]

CPT Pharmacometrics Syst Pharmacol
Abstract In oncology drug development, measuring drug concentrations at the tumor site and at the targeted receptor remains an ongoing challenge. Positron emission tomography (PET)‐imaging is a promising noninvasive method to quantify intratumor exposure of a radiolabeled drug (biodistribution data) and target saturation by treatment doses in vivo ...
Michelet R, Petersson K, Huisman MC, Menke-van der Houven van Oordt CW, Miedema IHC, Thiele A, Montaseri G, Pérez-Pitarch A, Busse D.   +8 more
europepmc   +2 more sources

TREC and KREC profiles in patients with inborn errors of immunity

Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)
TREC/KREC analysis is utilized in neonatal screening for the detection of primary immunodeficiencies caused by genetic defects in proteins essential for T- and B-lymphocyte development.
L. Yu. Barycheva, L. I. Bachieva, N. A. Kozmova, L. S. Khachirova, V. V. Kuznetsova   +4 more
openalex   +2 more sources

THE ROLE OF TREC AND KREC IN ASSESSING THE IMMUNE STATUS OF NEWBORNS

Eurasian journal of applied biotechnology
Newborn screening, based on the quantitative assessment of T-cell receptor excision circles (TREC) and kappa-deleting recombination excision circles (KREC) in dried blood spots, allows for the early diagnosis of various types of primary ...
Nurgul Sikhayeva, Svetlana Volodchenko, Elena Kovzel, M. Kissykova, Marina Morenko, К. О. Shnaider, Gulnar Tortayeva, Ye. Sagandykova   +7 more
openalex   +3 more sources

Rapid Charge Extraction via Hole and Electron Transfer Layers on Cu₂O Photocathode for Stable and Efficient Photoelectrochemical Water Reduction. [PDF]

Adv Sci (Weinh)
A simple strategy is developed to construct a unique “sandwich” structure of FeOOH/Cu2O/ZnO composite photocathode. FeOOH as HTL and ZnO as ETL promote the separation of photon‐generated carriers, reduce reaction energy barrier, and enhance the HER kinetic.
Huai S, Li X, Li P, Zhang S, Huang X, Ruan W, Chen J, Tang Z, Zhao X, Liu H, Wang X.   +10 more
europepmc   +2 more sources

An Intraspecific Negative Correlation Between the Repair Capacity of Photoinhibition of Cold Acclimated Plants and the Habitat Temperature. [PDF]

Plant Cell Environ
ABSTRACT Both the activity of photosynthesis and the repair of damaged photosystems decline in cold environments, which may increase the extent of the damage of photosynthetic machinery by light, namely photoinhibition. We hypothesized that plants in colder habitats may possess greater tolerance to photoinhibition, especially in low‐temperature ...
Oguchi R, Nagano S, Pfleger A, Ozaki H, Hikosaka K, Osmond B, Chow WS.   +6 more
europepmc   +2 more sources

The TREC/KREC assay for the diagnosis and monitoring of patients with DiGeorge syndrome. [PDF]

PLoS ONE, 2014
DiGeorge syndrome (DGS) presents with a wide spectrum of thymic pathologies. Nationwide neonatal screening programs of lymphocyte production using T-cell recombination excision circles (TREC) have repeatedly identified patients with DGS.
Eva Froňková, Adam Klocperk, Michael Svatoň, Michaela Nováková, Michaela Kotrová, Jana Kayserová, Tomáš Kalina, Petra Keslová, Felix Votava, Hana Vinohradská, Tomáš Freiberger, Ester Mejstříková, Jan Trka, Anna Sedivá   +13 more
doaj   +1 more source

TREC/KREC Levels in Young COVID-19 Patients

Diagnostics, 2021
COVID-19 patients with acute respiratory distress syndrome (ARDS) have an immune imbalance when systemic inflammation and dysfunction of circulating T and B cells lead to a more severe disease.
Maryam B. Khadzhieva, Ekaterina V. Kalinina, Sergey S. Larin, Daria A. Sviridova, Alesya S. Gracheva, Julia V. Chursinova, Vadim A. Stepanov, Ivan V. Redkin, Lyudmila S. Avdeikina, Alexander G. Rumyantsev, Artem N. Kuzovlev, Lyubov E. Salnikova   +11 more
doaj   +1 more source