Extracellular CIRP promotes Kupffer cell inflammatory polarization in sepsis [PDF]
Frontiers in ImmunologyIntroductionSepsis is a life-threatening inflammatory condition caused by dysregulated host responses to infection. Extracellular cold-inducible RNA-binding protein (eCIRP) is a recently discovered damage-associated molecular pattern that causes ...
Junji Shimizu +6 more
doaj +2 more sources
The role of heme in sepsis induced Kupffer cell PANoptosis and senescence [PDF]
Cell Death and DiseaseElevated heme levels, a consequence of hemolysis, are strongly associated with increased susceptibility to bacterial infections and adverse sepsis outcomes, particularly in older populations.
Tingting Li +12 more
doaj +2 more sources
Research and Application of Kupffer Cell Thresholds for BSA Nanoparticles [PDF]
Molecules, 2023 Over the past decade, the dose of nanoparticles given to solid tumors has remained at a median of 0.7% of the injected dose. Most nanoparticles are trapped in a mononuclear phagocyte system (MPS), of which 85% are Kupffer cells.
Huanhuan Guo +6 more
doaj +2 more sources
Monocyte-derived Kupffer cells dominate in the Kupffer cell pool during liver injury
Cell Reports, 2023 Summary: Healthy Kupffer cell (KC) pool is dominated by embryonic KCs (EmKCs), preserving liver homeostasis. How the KC pool varies upon injury remains unclear.
Weiyang Li +4 more
doaj +3 more sources
Kupffer Cell Inactivation Alters Endothelial Cell Adhesion Molecules in Cecal Ligation and Puncture-Induced Sepsis [PDF]
BiomoleculesThe activation of Kupffer cells, resident macrophages in the liver, is closely associated with the inflammatory response during sepsis, which leads to multiple-organ failure.
Sumeet Manandhar +3 more
doaj +2 more sources
Epigenetic Regulation of Kupffer Cell Function in Health and Disease
Frontiers in Immunology, 2021 Kupffer cells, the resident macrophages of the liver, comprise the largest pool of tissue macrophages in the body. Within the liver sinusoids Kupffer cells perform functions common across many tissue macrophages including response to tissue damage and ...
Hunter Bennett +5 more
doaj +1 more source
Pro-inflammatory activated Kupffer cells by lipids induce hepatic NKT cells deficiency through activation-induced cell death. [PDF]
PLoS ONE, 2013 BACKGROUND: Dietary lipids play an important role in the progression of non-alcoholic fatty liver disease (NAFLD) through alternation of liver innate immune response.
Tongfang Tang +4 more
doaj +1 more source
Open Medicine, 2021 Perivascular epithelioid cell tumor (PEComa) is a mesenchymal tumor rarely described in the liver. Sonazoid is a new ultrasound contrast with both vascular and post-vascular phases due to the uptake of Kupffer cell.
Li Chen, Xu Jing-Yong, Liu Yuan
doaj +1 more source
Frontiers in Immunology, 2022 Kupffer cells are the primary liver resident immune cell responsible for the liver firewall function, including clearance of bacterial infection from the circulation, as they are strategically positioned inside the liver sinusoid with intimate contact ...
Mateus Eustáquio Lopes +10 more
doaj +1 more source
Cross-activating invariant NKT cells and kupffer cells suppress cholestatic liver injury in a mouse model of biliary obstruction. [PDF]
PLoS ONE, 2013 Both Kupffer cells and invariant natural killer T (iNKT) cells suppress neutrophil-dependent liver injury in a mouse model of biliary obstruction. We hypothesize that these roles are interdependent and require iNKT cell-Kupffer cell cross-activation ...
Caroline C Duwaerts +4 more
doaj +1 more source