Results 61 to 70 of about 42,072 (228)

Intravital observation of Plasmodium berghei sporozoite infection of the liver. [PDF]

PLoS Biology, 2005
Plasmodium sporozoite invasion of liver cells has been an extremely elusive event to study. In the prevailing model, sporozoites enter the liver by passing through Kupffer cells, but this model was based solely on incidental observations in fixed ...
Ute Frevert, Sabine Engelmann, Sergine Zougbédé, Jörg Stange, Bruce Ng, Kai Matuschewski, Leonard Liebes, Herman Yee   +7 more
doaj   +1 more source

Rodent monocyte‐derived macrophages do not express CD163: Comparative analysis using macrophages from living boreoeutherians

Developmental Dynamics, EarlyView.
Abstract Background CD163 is a scavenger receptor predominantly expressed on the surfaces of macrophages in various mammalian species and is a marker of anti‐inflammatory (M2‐like) macrophages. High density of CD163‐positive tumor‐associated macrophages (TAMs) is associated with worse prognosis in various patient tumors.
Yoichi Saito, Yukio Fujiwara, Yasuka L. Yamaguchi, Satomi S. Tanaka, Kyoko Miura, Yoshiyuki Hizukuri, Kyoko Yamashiro, Yasuhiro Hayashi, Yuta Nakashima, Yoshihiro Komohara   +9 more
wiley   +1 more source

The Antidepressant Mirtazapine Activates Hepatic Macrophages, Facilitating Pathogen Clearance While Limiting Tissue Damage in Mice

Frontiers in Immunology, 2020
Background and AimsMirtazapine is an atypical antidepressant with antagonist activity for serotonin and histamine receptors. Clinical and experimental evidence suggests that, in addition to treating depression, mirtazapine also alters liver innate ...
Rachelle Paige Davis, Rachelle Paige Davis, Wagdi Almishri, Wagdi Almishri, Craig Neal Jenne, Craig Neal Jenne, Mark Gordon Swain, Mark Gordon Swain   +7 more
doaj   +1 more source

Kupffer cells in hepatotoxicity

EXCLI journal, 2020
EXCLI Journal; 19:Doc1156; ISSN 1611 ...
openaire   +3 more sources

Kupffer cells and their function [PDF]

Liver, 1987
ABSTRACT— The intention of this review is to stress new information regarding the quite versatile functions of Kupffer cells. Although their main function is phagocytosis and defence of the liver against bacteria, endotoxaemia and viral infections, they also fulfil other important roles.
openaire   +2 more sources

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Microengineering the Liver: Strategies for Constructing Functional Liver‐on‐a‐Chip Devices

Exploration, EarlyView.
This review summarizes recent advances in liver‐on‐a‐chip (LOC) technologies, including fabrication strategies and functional integration approaches, and discusses their promising applications in drug screening and related biomedical fields. ABSTRACT Reliable in vitro liver models are indispensable for researching liver diseases and developing ...
Jie Wang, Ziwei Liang, Jiapu Wang, Zongyi Li, Shaojie Wang, Yan Wei, Xin Xie, Di Huang   +7 more
wiley   +1 more source

3D co-cultures of primary human hepatocytes and Kupffer-like cells to address innate immune responses to rAAV

Scientific Reports
Recombinant adeno-associated viruses (rAAVs) are a platform of choice for gene therapy. However, liver-directed transduction has been hindered by immune responses unpredicted in the pre-clinical models, resulting in therapy failure.
Isabella Ramella Gal, Francisca Arez, Inês P. Correia, Giacomo Domenici, Sofia Fernandes, Gabriela Silva, Inês Saldanha, Nadia Duarte, Catarina Freitas, Paula M. Alves, Udo Maier, Ana Sofia Coroadinha, François du Plessis, Catarina Brito   +13 more
doaj   +1 more source

A Coculture Model of Intrahepatic Islet Transplantation: Activation of Kupffer Cells by Islets and Acinar Tissue

Cell Transplantation, 2001
Clinical and experimental studies of intrahepatic islet transplantation have allowed histological and systemic observations to be made, but the location of the transplanted islets makes it difficult to assess direct effects on the cells of the liver.
Heather A. Clayton, Joanna E. Davies, Chris D. Sutton, Peter R. F. Bell, Ashley R. Dennison   +4 more
doaj   +1 more source

Apolipoprotein E is secreted by cultured lipocytes of the rat liver.

Journal of Lipid Research, 1991
Hepatic lipocytes, the retinoid-storing cells of the liver, share several characteristics with vascular smooth muscle cells. To determine whether they also share the characteristic of apolipoprotein E secretion, we have compared the relative mRNA ...
G Friedman, LM Liu, SL Friedman, JK Boyles   +3 more
doaj   +1 more source