Results 141 to 150 of about 5,018,081 (294)

The Opposite Effects of Kynurenic Acid and Different Kynurenic Acid Analogs on Tumor Necrosis Factor-α (TNF-α) Production and Tumor Necrosis Factor-Stimulated Gene-6 (TSG-6) Expression

Frontiers in Immunology, 2019
Purpose: The investigation of anti-inflammatory and immunosuppressive functions of Kynurenic acid (KYNA) is now in focus. There is also substantial evidence that TSG-6 has an anti-inflammatory activity.
Y. Mándi, V. Endrész, Tímea Mosolygó, K. Burián, Ildikó Lantos, F. Fülöp, I. Szatmári, Bálint Lőrinczi, A. Balog, L. Vécsei   +9 more
semanticscholar   +1 more source

Functional Impairments in Learning and Signal Propagation Following Prenatal Kynurenine Treatment in Mice

European Journal of Neuroscience, Volume 62, Issue 1, July 2025.
ABSTRACT The levels of kynurenic acid (KYNA), a metabolite of the kynurenine pathway (KP) of tryptophan degradation, are elevated in the brain of persons with schizophrenia (SZ) and may be linked to cognitive dysfunctions in the disease. Studies in rats indicate that abnormally high fetal brain KYNA may play a pathophysiologically significant role in ...
Sarah Beggiato, P. Leon Brown, Snezana Milosavljevic, Marian A. R. Thomas, Maria V. Piroli, Korrapati V. Sathyasaikumar, Francesca M. Notarangelo, Robert Schwarcz, Ana Pocivavsek   +8 more
wiley   +1 more source

Sex differences in peripheral and central dysregulation of the kynurenine pathway in Parkinson’s disease

npj Parkinson's Disease
We previously demonstrated that kynurenine pathway (KP) dysregulation associates with Parkinson’s disease (PD) and its symptoms. Here, we profiled 16 KP-related markers in a second, independent cohort; plasma: n = 202 (116 PD (“OFF”), 86 controls); CSF ...
Leslie C. Jellen, Martha L. Escobar Galvis, Qiong Sha, Christine Isaguirre, Amy Johnson, Zach Madaj, Mechelle M. Lewis, Ryan D. Sheldon, Lan Kong, Xuemei Huang, Lena Brundin   +10 more
doaj   +1 more source

Physicochemical Characterization of Kynurenine Pathway Metabolites

Antioxidants
The kynurenine pathway is a significant metabolic route involved in the catabolism of tryptophan, producing various bioactive metabolites with crucial roles as antioxidants in immune regulation and neurobiology.
Luca Buzásy, Károly Mazák, Balázs Balogh, Balázs Simon, Anna Vincze, György Tibor Balogh, Tamás Pálla, Arash Mirzahosseini   +7 more
doaj   +1 more source

Kynurenic acid, an IDO metabolite, controls TSG-6-mediated immunosuppression of human mesenchymal stem cells

Cell Death and Differentiation, 2017
Mesenchymal stem cells (MSCs) have been demonstrated to be anti-inflammatory against various immune disorders through several factors, including indoleamine 2,3-dioxygenase (IDO) and TNF-stimulated gene 6 (TSG-6).
Guan Wang, K. Cao, Keli Liu, Yueqing Xue, A. Roberts, Fengying Li, Yanyan Han, A. Rabson, Ying Wang, Yufang Shi   +9 more
semanticscholar   +1 more source

Metabolic Alterations Associated With Rapidly Progressive Chronic Kidney Disease in Cats

Journal of Veterinary Internal Medicine, Volume 39, Issue 4, July/August 2025.
ABSTRACT Background Chronic kidney disease (CKD) in cats often remains stable over time, but some cats experience progressive kidney dysfunction without an identifiable cause. Objectives Identify differences in serum and urine compounds related to tryptophan metabolism and gut‐derived uremic toxins between cohorts with non‐progressive and rapidly ...
Laurens van Mulders, Ellen vanden Broecke, Femke Mortier, Ellen de Paepe, Lynn Vanhaecke, Sylvie Daminet   +5 more
wiley   +1 more source

Development of a translational inflammation panel for the quantification of cerebrospinal fluid Pterin, Tryptophan-Kynurenine and Nitric oxide pathway metabolites

EBioMedicine, 2022
Summary: Background: Neuroinflammatory diseases such as encephalitis, meningitis, multiple sclerosis and other neurological diseases with inflammatory components, have demonstrated a need for diagnostic biomarkers to define treatable and reversible ...
Jingya Yan, Velda X. Han, Benjamin Heng, Gilles J. Guillemin, Sushil Bandodkar, Russell C. Dale   +5 more
doaj  

Systemic L-Kynurenine sulfate administration disrupts object recognition memory, alters open field behavior and decreases c-Fos immunopositivity in C57Bl/6 mice [PDF]

, 2015
L-Kynurenine (L-KYN) is a central metabolite of tryptophan degradation through the kynurenine pathway (KP). The systemic administration of L-KYN sulfate (L-KYNs) leads to a rapid elevation of the neuroactive KP metabolite kynurenic acid (KYNA).
Dániel Varga, Etsuro Ono, Hiroki Takakuwa, Judit Herédi, József Toldi, Levente Gellért, László Vécsei, Marian Ruszka, Naoki Iwamori, Tokuko Iwamori, Zita Kánvási, Zsolt Kis   +11 more
core   +1 more source

Structural Evaluation and Electrophysiological Effects of Some Kynurenic Acid Analogs

Molecules, 2019
Kynurenic acid (KYNA), a metabolite of tryptophan, as an excitatory amino acid receptor antagonist is an effective neuroprotective agent in case of excitotoxicity, which is the hallmark of brain ischemia and several neurodegenerative processes. Therefore,
Evelin Fehér, I. Szatmári, Tamás Dudás, Anna Zalatnai, T. Farkas, Bálint Lőrinczi, F. Fülöp, L. Vécsei, J. Toldi   +8 more
semanticscholar   +1 more source

Lactobacillus regulate muscle fiber type conversion in Chinese native pigs via tryptophan metabolism

npj Biofilms and Microbiomes
Identifying potential gut microbes and metabolites that can influence muscle fiber type is gaining interest in meat quality research. In this study, muscle fiber characteristics, muscle metabolite profiles, and gut microbiota and metabolome were compared
Bo Song, Md. Abul Kalam Azad, Qian Zhu, Yating Cheng, Sujuan Ding, Kang Yao, Xiangfeng Kong   +6 more
doaj   +1 more source