Results 1 to 10 of about 40,027 (305)

The Kynurenine Pathway and Kynurenine 3-Monooxygenase Inhibitors [PDF]

Molecules, 2022
Under normal physiological conditions, the kynurenine pathway (KP) plays a critical role in generating cellular energy and catabolizing tryptophan.
Tamera D. Hughes, Osman F. Güner, Emma Carine Iradukunda, Robert S. Phillips, J. Phillip Bowen   +4 more
doaj   +4 more sources

The tryptophan–kynurenine pathway in immunomodulation and cancer metastasis

Cancer Medicine, 2023
Introduction The activation of the kynurenine pathway in cancer progression and metastasis through immunomodulatory pathways has drawn attention to the potential for kynurenine pathway inhibition.
Charlise Basson, June Cheptoo Serem, Yvette Nkondo Hlophe, Priyesh Bipath   +3 more
doaj   +2 more sources

Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes

Journal for ImmunoTherapy of Cancer, 2023
Background Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan-dioxygenase (TDO) are enzymes catabolizing the essential amino acid tryptophan into kynurenine.
Luc Pilotte, Benoit J Van den Eynde, Jingjing Zhu, Christine Sers, Marie Solvay, Pauline Holfelder, Simon Klaessens, Vincent Stroobant, Juliette Lamy, Stefan Naulaerts, Quentin Spillier, Raphaël Frédérick, Etienne De Plaen, Christiane A Opitz   +13 more
doaj   +2 more sources

Neopterin and Kynurenine in Mesangioproliferative Glomerulonephritis [PDF]

Pteridines, 1998
Serum kynurenine and neopterin concentrations were determined in patients with chronic mesangioproliferative glomerulonephritis with normal renal function and in patients with chronic renal failure. Significantly increased kynurenine and neopterin levels
Martinsons Agris, Rudzite Vera, Widner Bernhard, Fuchs Dietmar   +3 more
doaj   +2 more sources

Brain Versus Blood: A Systematic Review on the Concordance Between Peripheral and Central Kynurenine Pathway Measures in Psychiatric Disorders

Frontiers in Immunology, 2021
ObjectiveDisturbances in the kynurenine pathway have been implicated in the pathophysiology of psychotic and mood disorders, as well as several other psychiatric illnesses.
Katrien Skorobogatov, Katrien Skorobogatov, Livia De Picker, Livia De Picker, Robert Verkerk, Violette Coppens, Violette Coppens, Marion Leboyer, Marion Leboyer, Marion Leboyer, Marion Leboyer, Norbert Müller, Manuel Morrens, Manuel Morrens   +13 more
doaj   +2 more sources

A history of suicide attempts among individuals with schizophrenia is associated with tryptophan degradation via the salivary kynurenine pathway [PDF]

BMC Psychiatry
Background Tryptophan, an essential precursor metabolite within the kynurenine pathway, has been implicated in the neurobiological mechanisms underlying both schizophrenia and associated suicidality. Despite this link, the lack of validated biomarkers to
Yi Yin, Ting Xie, Jinghui Tong, Junchao Huang, Baopeng Tian, Mengzhuang Gou, Song Chen, Shuping Tan, Zhiren Wang, Yongsheng Tong, Yanfang Zhou, Leilei Wang, Yunlong Tan   +12 more
doaj   +2 more sources

RETRACTED ARTICLE: Kynurenine promotes neonatal heart regeneration by stimulating cardiomyocyte proliferation and cardiac angiogenesis

Nature Communications, 2022
Indoleamine 2,3 dioxygenase-1 (IDO1) catalyzes tryptophan-kynurenine metabolism in many inflammatory and cancer diseases. Of note, acute inflammation that occurs immediately after heart injury is essential for neonatal cardiomyocyte proliferation and ...
Donghong Zhang, Jinfeng Ning, Tharmarajan Ramprasath, Changjiang Yu, Xiaoxu Zheng, Ping Song, Zhonglin Xie, Ming-Hui Zou   +7 more
doaj   +2 more sources

Kynurenine Pathway Metabolites as Potential Clinical Biomarkers in Coronary Artery Disease

Frontiers in Immunology, 2022
Coronary artery disease (CAD) is one of the leading cause of mortality worldwide. Several risk factors including unhealthy lifestyle, genetic background, obesity, diabetes, hypercholesterolemia, hypertension, smoking, age, etc.
Renáta Gáspár, Renáta Gáspár, Dóra Halmi, Dóra Halmi, Virág Demján, Virág Demján, Róbert Berkecz, Márton Pipicz, Márton Pipicz, Tamás Csont, Tamás Csont   +10 more
doaj   +2 more sources

Kynurenine induces T cell fat catabolism and has limited suppressive effects in vivo

EBioMedicine, 2021
Background: L-kynurenine is a tryptophan-derived immunosuppressive metabolite and precursor to neurotoxic anthranilate and quinolinate. We evaluated the stereoisomer D-kynurenine as an immunosuppressive therapeutic which is hypothesized to produce less ...
Peter J. Siska, Jing Jiao, Carina Matos, Katrin Singer, Raffaela S. Berger, Katja Dettmer, Peter J. Oefner, Michelle D. Cully, Zhonglin Wang, William J. QuinnIII, Kristen N. Oliff, Benjamin J. Wilkins, Lanette M. Christensen, Liqing Wang, Wayne W. Hancock, Joseph A. Baur, Matthew H. Levine, Ines Ugele, Roman Mayr, Kathrin Renner, Liang Zhou, Marina Kreutz, Ulf H. Beier   +22 more
doaj   +1 more source

The Tryptophan and Kynurenine Pathway Involved in the Development of Immune-Related Diseases

International Journal of Molecular Sciences, 2023
The tryptophan and kynurenine pathway is well-known to play an important role in nervous, endocrine, and immune systems, as well as in the development of inflammatory diseases.
Ai Tsuji, Yuka Ikeda, Sayuri Yoshikawa, Kurumi Taniguchi, Haruka Sawamura, Sae Morikawa, Moeka Nakashima, Tomoko T. Asai, Satoru Matsuda   +8 more
semanticscholar   +1 more source