Results 11 to 20 of about 55,792 (321)
The Kynurenine Pathway and Kynurenine 3-Monooxygenase Inhibitors [PDF]
Molecules, 2022 Under normal physiological conditions, the kynurenine pathway (KP) plays a critical role in generating cellular energy and catabolizing tryptophan.
Tamera D. Hughes +4 more
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Journal for ImmunoTherapy of Cancer, 2023 Background Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan-dioxygenase (TDO) are enzymes catabolizing the essential amino acid tryptophan into kynurenine.
Luc Pilotte +13 more
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Nature Communications, 2022 Indoleamine 2,3 dioxygenase-1 (IDO1) catalyzes tryptophan-kynurenine metabolism in many inflammatory and cancer diseases. Of note, acute inflammation that occurs immediately after heart injury is essential for neonatal cardiomyocyte proliferation and ...
Donghong Zhang +7 more
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Kynurenine Pathway Metabolites as Potential Clinical Biomarkers in Coronary Artery Disease
Frontiers in Immunology, 2022 Coronary artery disease (CAD) is one of the leading cause of mortality worldwide. Several risk factors including unhealthy lifestyle, genetic background, obesity, diabetes, hypercholesterolemia, hypertension, smoking, age, etc.
Renáta Gáspár +10 more
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Abnormal Activation of Tryptophan-Kynurenine Pathway in Women With Polycystic Ovary Syndrome
Frontiers in Endocrinology, 2022 BackgroundWomen with polycystic ovary syndrome (PCOS) suffer from dysfunctional metabolism and studies have reported increased levels of tryptophan in patients with PCOS.
Siyu Wang +25 more
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Modulation of Enzyme Activity in the Kynurenine Pathway by Kynurenine Monooxygenase Inhibition [PDF]
Frontiers in Molecular Biosciences, 2019 The kynurenine pathway is the major route for tryptophan metabolism in mammals. Several of the metabolites in the kynurenine pathway, however, are potentially toxic, particularly 3-hydroxykynurenine, 3-hydroxyanthranilic acid, and quinolinic acid ...
Robert S. Phillips +4 more
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THE TRANSAMINATION OF KYNURENINE
Journal of Biological Chemistry, 1953 Irving L. Miller +2 more
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Kynurenine: an oncometabolite in colon cancer [PDF]
Cell Stress, 2020 Tryptophan is one of the eight essential amino acids that must be obtained from the diet. Interestingly, tryptophan is the least abundant amino acid in most proteins, a large portion of cellular tryptophan is converted into metabolites of the serotonin ...
Niranjan Venkateswaran +1 more
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The Tryptophan and Kynurenine Pathway Involved in the Development of Immune-Related Diseases
International Journal of Molecular Sciences, 2023 The tryptophan and kynurenine pathway is well-known to play an important role in nervous, endocrine, and immune systems, as well as in the development of inflammatory diseases.
Ai Tsuji +8 more
semanticscholar +1 more source