Results 11 to 20 of about 48,449 (279)
The Kynurenine Pathway and Kynurenine 3-Monooxygenase Inhibitors [PDF]
Molecules, 2022 Under normal physiological conditions, the kynurenine pathway (KP) plays a critical role in generating cellular energy and catabolizing tryptophan.
Tamera D. Hughes +4 more
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THE TRANSAMINATION OF KYNURENINE
Journal of Biological Chemistry, 1953 Irving L. Miller +2 more
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Modulation of Enzyme Activity in the Kynurenine Pathway by Kynurenine Monooxygenase Inhibition [PDF]
Frontiers in Molecular Biosciences, 2019 The kynurenine pathway is the major route for tryptophan metabolism in mammals. Several of the metabolites in the kynurenine pathway, however, are potentially toxic, particularly 3-hydroxykynurenine, 3-hydroxyanthranilic acid, and quinolinic acid ...
Robert S. Phillips +4 more
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Kynurenine: an oncometabolite in colon cancer [PDF]
Cell Stress, 2020 Tryptophan is one of the eight essential amino acids that must be obtained from the diet. Interestingly, tryptophan is the least abundant amino acid in most proteins, a large portion of cellular tryptophan is converted into metabolites of the serotonin ...
Niranjan Venkateswaran +1 more
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Cluster headache and kynurenines
The Journal of Headache and Pain, 2023 AbstractBackgroundThe glutamatergic neurotransmission has important role in the pathomechanism of primary headache disorders. The kynurenine metabolites derived from catabolism of tryptophan (Trp) have significant involvement not only in glutamatergic processes, but also in the neuroinflammation, the oxidative stress and the mitochondrial dysfunctions.
Tuka Bernadett +8 more
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Kynurenine pathway in kidney diseases [PDF]
Pharmacological Reports, 2021 AbstractKidney diseases have become one of the most common health care problems. Due to a growing number of advanced aged patients with concomitant disorders the prevalence of these diseases will increase over the coming decades. Despite available laboratory tests, accurate and rapid diagnosis of renal dysfunction has yet to be realized, and prognosis ...
Izabela Zakrocka, Wojciech Załuska
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PLoS ONE, 2020 BackgroundWe examined serum kynurenine levels in patients with chronic hepatitis C virus infection, and the relationship between serum kynurenine and prognosis in patients with hepatocellular carcinoma (HCC) and chronic hepatitis C.MethodsWe ...
Shigemune Bekki +13 more
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Journal of Neuroinflammation, 2021 Background Administration of lipopolysaccharide (LPS) from Gram-negative bacteria, also known as the human endotoxemia model, is a standardized and safe model of human inflammation. Experimental studies have revealed that peripheral administration of LPS
Vincent Millischer +9 more
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An expanding range of targets for kynurenine metabolites of tryptophan [PDF]
, 2013 The kynurenine pathway of tryptophan metabolism accounts for most of the tryptophan that is not committed to protein synthesis and includes compounds active in the nervous and immune systems.
Darlington, L. Gail +2 more
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