Results 11 to 20 of about 40,027 (305)
THE TRANSAMINATION OF KYNURENINE
Journal of Biological Chemistry, 1953 Irving L. Miller +2 more
openalex +3 more sources
Diagnostics, 2022 Kynurenine is a tryptophan metabolite linked to several inflammatory processes including transplant failure, a significant challenge in transplant medicine. The detection of small molecules such as kynurenine, however, is often complex and time consuming.
Max Borgolte +4 more
doaj +1 more source
International Journal of Molecular Sciences, 2022 Depression is a common and serious disorder, characterized by symptoms like anhedonia, lack of energy, sad mood, low appetite, and sleep disturbances.
A. Correia, N. Vale
semanticscholar +1 more source
Scientific Reports, 2021 Inflammation increases the risk of cardiometabolic disease. Delineating specific inflammatory pathways and biomarkers of their activity could identify the mechanistic underpinnings of the increased risk. Plasma levels of kynurenine, a metabolite involved
Minoo Bagheri +16 more
doaj +1 more source
The kynurenine pathway of tryptophan catabolism and schizophrenia [PDF]
Medicinski Podmladak, 2023 The development of new therapeutic options focused on the recovery of patients with schizophrenia is primarily conditioned by elucidating the biological underpinnings of the disorder.
Marković Miloš +2 more
doaj +1 more source
Gut microbes, 2021 Emerging evidence suggests that the gut microbiota may interact with the host brain and play pivotal roles in the pathogenesis of neuropsychiatric disorders. However, the mechanism underlying reciprocal interactions along the microbiota-gut-brain axis in
Yuanyuan Deng +8 more
semanticscholar +1 more source
Kynurenine Pathway in Diabetes Mellitus—Novel Pharmacological Target?
Cells, 2023 The tryptophan–kynurenine pathway (Trp–KYN) is the major route for tryptophan conversion in the brain and in the periphery. Kynurenines display a wide range of biological actions (which are often contrasting) such as cytotoxic/cytoprotective, oxidant ...
K. Kozieł, E. Urbanska
semanticscholar +1 more source
JCI Insight, 2020 Reprogramming of host metabolism supports viral pathogenesis by fueling viral proliferation, by providing, for example, free amino acids and fatty acids as building blocks.
Tiffany A. Thomas +11 more
semanticscholar +1 more source
Immune Influencers in Action: Metabolites and Enzymes of the Tryptophan-Kynurenine Metabolic Pathway
Biomedicines, 2021 The tryptophan (TRP)-kynurenine (KYN) metabolic pathway is a main player of TRP metabolism through which more than 95% of TRP is catabolized. The pathway is activated by acute and chronic immune responses leading to a wide range of illnesses including ...
Masaru Tanaka +5 more
semanticscholar +1 more source
Nature Communications, 2022 Aberrant amino acid metabolism is a common event in obesity. Particularly, subjects with obesity are characterized by the excessive plasma kynurenine (Kyn).
Teng Huang +16 more
semanticscholar +1 more source