Results 21 to 30 of about 55,792 (321)
Kynurenine Pathway in Diabetes Mellitus—Novel Pharmacological Target?
Cells, 2023 The tryptophan–kynurenine pathway (Trp–KYN) is the major route for tryptophan conversion in the brain and in the periphery. Kynurenines display a wide range of biological actions (which are often contrasting) such as cytotoxic/cytoprotective, oxidant ...
K. Kozieł, E. Urbanska
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The Role of the Kynurenine Pathway in the Pathophysiology of Frailty, Sarcopenia, and Osteoporosis
Nutrients, 2023 Tryptophan is an essential nutrient required to generate vitamin B3 (niacin), which is mainly involved in energy metabolism and DNA production. Alterations in tryptophan metabolism could have significant effects on aging and musculoskeletal health.
J. Ballesteros, D. Rivas, Gustavo Duque
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International Journal of Molecular Sciences, 2022 Depression is a common and serious disorder, characterized by symptoms like anhedonia, lack of energy, sad mood, low appetite, and sleep disturbances.
A. Correia, N. Vale
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Cancers, 2023 Simple Summary There is clear evidence that inflammation can contribute to the development of cancers, but the underlying mechanisms are not fully understood.
T. Stone, Richard O. Williams
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Cluster headache and kynurenines
The Journal of Headache and Pain, 2023 AbstractBackgroundThe glutamatergic neurotransmission has important role in the pathomechanism of primary headache disorders. The kynurenine metabolites derived from catabolism of tryptophan (Trp) have significant involvement not only in glutamatergic processes, but also in the neuroinflammation, the oxidative stress and the mitochondrial dysfunctions.
Tuka Bernadett +8 more
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Nature Communications, 2022 Aberrant amino acid metabolism is a common event in obesity. Particularly, subjects with obesity are characterized by the excessive plasma kynurenine (Kyn).
Teng Huang +16 more
semanticscholar +1 more source
Gut microbes, 2021 Emerging evidence suggests that the gut microbiota may interact with the host brain and play pivotal roles in the pathogenesis of neuropsychiatric disorders. However, the mechanism underlying reciprocal interactions along the microbiota-gut-brain axis in
Yuanyuan Deng +8 more
semanticscholar +1 more source
JCI Insight, 2020 Reprogramming of host metabolism supports viral pathogenesis by fueling viral proliferation, by providing, for example, free amino acids and fatty acids as building blocks.
Tiffany A. Thomas +11 more
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Immune Influencers in Action: Metabolites and Enzymes of the Tryptophan-Kynurenine Metabolic Pathway
Biomedicines, 2021 The tryptophan (TRP)-kynurenine (KYN) metabolic pathway is a main player of TRP metabolism through which more than 95% of TRP is catabolized. The pathway is activated by acute and chronic immune responses leading to a wide range of illnesses including ...
Masaru Tanaka +5 more
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IDO/kynurenine pathway in cancer: possible therapeutic approaches
Journal of Translational Medicine, 2022 Cancer is one of the leading causes of death in both men and women worldwide. One of the main changes associated with cancer progression, metastasis, recurrence, and chemoresistance is the change in the tumor immune microenvironment, especially ...
E. A. Abd El-Fattah
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