Results 21 to 30 of about 40,027 (305)

The Role of the Kynurenine Pathway in the Pathophysiology of Frailty, Sarcopenia, and Osteoporosis

Nutrients, 2023
Tryptophan is an essential nutrient required to generate vitamin B3 (niacin), which is mainly involved in energy metabolism and DNA production. Alterations in tryptophan metabolism could have significant effects on aging and musculoskeletal health.
J. Ballesteros, D. Rivas, Gustavo Duque
semanticscholar   +1 more source

Expression of the Kynurenine Pathway in Human Peripheral Blood Mononuclear Cells: Implications for Inflammatory and Neurodegenerative Disease. [PDF]

PLoS ONE, 2015
The kynurenine pathway is a fundamental mechanism of immunosuppression and peripheral tolerance. It is increasingly recognized as playing a major role in the pathogenesis of a wide variety of inflammatory, neurodegenerative and malignant disorders ...
Simon P Jones, Nunzio F Franco, Bianca Varney, Gayathri Sundaram, David A Brown, Josien de Bie, Chai K Lim, Gilles J Guillemin, Bruce J Brew   +8 more
doaj   +1 more source

Interactions of IDO and the Kynurenine Pathway with Cell Transduction Systems and Metabolism at the Inflammation–Cancer Interface

Cancers, 2023
Simple Summary There is clear evidence that inflammation can contribute to the development of cancers, but the underlying mechanisms are not fully understood.
T. Stone, Richard O. Williams
semanticscholar   +1 more source

Serum kynurenine levels are a novel biomarker to predict the prognosis of patients with hepatocellular carcinoma.

PLoS ONE, 2020
BackgroundWe examined serum kynurenine levels in patients with chronic hepatitis C virus infection, and the relationship between serum kynurenine and prognosis in patients with hepatocellular carcinoma (HCC) and chronic hepatitis C.MethodsWe ...
Shigemune Bekki, Satoru Hashimoto, Kazumi Yamasaki, Atsumasa Komori, Seigo Abiru, Shinya Nagaoka, Akira Saeki, Tomoyuki Suehiro, Yuki Kugiyama, Asami Beppu, Tamotsu Kuroki, Minoru Nakamura, Masahiro Ito, Hiroshi Yatsuhashi   +13 more
doaj   +1 more source

Plasma Tryptophan-Kynurenine Pathway Metabolites and Risk for Progression to End-Stage Kidney Disease in Patients With Type 2 Diabetes

Diabetes Care, 2023
OBJECTIVE We sought to study the associations between plasma metabolites in the tryptophan-kynurenine pathway and the risk of progression to end-stage kidney disease (ESKD) in patients with type 2 diabetes.
Jian-Jun Liu, J. Ching, H. Wee, Sylvia Liu, R. L. Gurung, Janus Lee, Y. M., Huili Zheng, Lye Siang Lee, K. Ang, Y. Shao, Jean-Paul Kovalik, T. Subramaniam, C. Sum, Kumar Sharma, B. Kestenbaum, S. Lim   +16 more
semanticscholar   +1 more source

Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine

Nature Communications, 2020
Tryptophan catabolism by the enzymes indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase 2 (IDO/TDO) promotes immunosuppression across different cancer types.
L. F. Campesato, S. Budhu, J. Tchaicha, Chien-Huan Weng, M. Gigoux, Ivan J. Cohen, D. Redmond, L. Mangarin, S. Pourpe, Cailian Liu, R. Zappasodi, D. Zamarin, Jillian D. Cavanaugh, Alfredo C Castro, M. Manfredi, Karen McGovern, T. Merghoub, J. Wolchok   +17 more
semanticscholar   +1 more source

Intravenous administration of LPS activates the kynurenine pathway in healthy male human subjects: a prospective placebo-controlled cross-over trial

Journal of Neuroinflammation, 2021
Background Administration of lipopolysaccharide (LPS) from Gram-negative bacteria, also known as the human endotoxemia model, is a standardized and safe model of human inflammation. Experimental studies have revealed that peripheral administration of LPS
Vincent Millischer, Matthias Heinzl, Anthi Faka, Michael Resl, Ada Trepci, Carmen Klammer, Margot Egger, Benjamin Dieplinger, Martin Clodi, Lilly Schwieler   +9 more
doaj   +1 more source

Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease

Journal of Neuroinflammation, 2021
Inflammatory bowel disease (IBD), which mainly includes ulcerative colitis (UC) and Crohn's disease (CD), is a group of chronic bowel diseases that are characterized by abdominal pain, diarrhea, and bloody stools.
Li-ming Chen, Chunhui Bao, Yu Wu, Shiwei Liang, Di Wang, Luyi Wu, Yan Huang, Hui-rong Liu, Huan-gan Wu   +8 more
semanticscholar   +1 more source

A systematic review and meta-analysis of the kynurenine pathway of tryptophan metabolism in rheumatic diseases

Frontiers in Immunology, 2023
There is an increasing interest in the pathophysiological role of the kynurenine pathway of tryptophan metabolism in the regulation of immune function and inflammation.
Arduino A. Mangoni, Arduino A. Mangoni, Angelo Zinellu   +2 more
doaj   +1 more source

Role of Kynurenine Pathway in Oxidative Stress during Neurodegenerative Disorders

Cells, 2021
Neurodegenerative disorders are chronic and life-threatening conditions negatively affecting the quality of patients’ lives. They often have a genetic background, but oxidative stress and mitochondrial damage seem to be at least partly responsible for ...
A. Mor, A. Tankiewicz-Kwedlo, A. Krupa, D. Pawlak   +3 more
semanticscholar   +1 more source