Results 41 to 50 of about 26,011 (207)
Journal of Oral Pathology &Medicine, Volume 52, Issue 1, Page 9-19, January 2023., 2023 Abstract Myeloid‐derived suppressor cells (MDSCs) help establish the tumor microenvironment by suppressing T‐cell response in tumor‐bearing hosts. Plasmacytoid dendritic cells (pDCs) activate antigen‐specific T cells, thereby, maximizing their antitumor effects.
Atsumu Kouketsu +7 more
wiley +1 more source
IFNγ-INDUCED KINURENINE PRODUCTION AND INDOLAMINE 2,3-DIOXYGENASE GENE EXPRESSION IN PSORIASIS
Медицинская иммунология, 2014 . An alternative pathway of L-tryptophan biotransformation is provided by the indolamine 2,3-dioxygenase (INDO), and it results into synthesis of kynurenine and other «distal» metabolites, playing a pivotal role in immunoregulation and down-regulation of
D. A. Kaut +5 more
doaj +1 more source
Abnormal Activation of Tryptophan-Kynurenine Pathway in Women With Polycystic Ovary Syndrome
Frontiers in Endocrinology, 2022 BackgroundWomen with polycystic ovary syndrome (PCOS) suffer from dysfunctional metabolism and studies have reported increased levels of tryptophan in patients with PCOS.
Siyu Wang +25 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.Abstract Objectives This study sought to evaluate proteomic, metabolomic, and immune signatures in the cerebrospinal fluid of individuals with Down Syndrome Regression Disorder (DSRD). Methods A prospective case–control study comparing proteomic, metabolomic, and immune profiles in individuals with DSRD was performed.
Jonathan D. Santoro +12 more
wiley +1 more source
Advanced Synthesis &Catalysis, EarlyView.Abstract Unnatural amino acids play a crucial role in advancing protein engineering and drug development. In this study, we present the synthesis of a series of γ‐aryl‐keto‐α‐amino acids through the direct C−H arylation of readily accessible β‐aminoaldehydes and aryl bromides, promoted by hydrogen atom transfer combined with metallaphotoredox catalysis.
Mariana dos S. Dupim +3 more
wiley +1 more source
Advanced Science, EarlyView.Lycium barbarum glycopeptide (LBGP), which is further extracted from Lycium barbarum polysaccharides, exhibits significant protective effects against neomycin‐induced hearing dysfunction including oxidative stress in cochlea and loss of key cells in cochlea.
Yunhao Wu +12 more
wiley +1 more source
Immunometabolic Network Interactions of the Kynurenine Pathway in Cutaneous Malignant Melanoma
Frontiers in Oncology, 2020 Dysregulation of the kynurenine pathway has been regarded as a mechanism of tumor immune escape by the enzymatic activity of indoleamine 2, 3 dioxygenase and kynurenine production. However, the immune-modulatory properties of other kynurenine metabolites
Soudabeh Rad Pour +17 more
doaj +1 more source
Advanced Science, EarlyView.Using a 3D tumor microenvironment (TME)‐on‐a‐chip model, tumor–stromal–immune crosstalk in triple‐negative breast cancer is studied, revealing the TME's combinatorial effect on cancer progression. Integrating single‐cell transcriptomic analysis demonstrates metabolic reprogramming via the kynurenine pathway, highlighting the complex TME cellular ...
Kalpana Ravi +7 more
wiley +1 more source
Decoding Blastocystis‐Driven Mechanisms in Gut Microbiota and Host Metabolism
Advanced Science, EarlyView.Blastocystis, a prevalent gut microbe, interacts with the host through metabolic and immune pathways, influencing cardiometabolic health. This perspective explores its role in modulating short‐chain fatty acid production, tryptophan metabolism, and immune signaling, potentially impacting cholesterol absorption, glucose metabolism, and vascular health ...
Lei Deng, Kevin SW Tan
wiley +1 more source
European Psychiatry, 2021 Introduction The tryptophan pathway along with its two branches of metabolism to serotonin and kynurenine seems to be affected in major depression.
R. Colle +4 more
doaj +1 more source