Results 41 to 50 of about 40,027 (305)
Kidney & Blood Pressure Research, 2019 Background: Kynurenine, a metabolite of the L-tryptophan pathway, plays a pivotal role in neuro-inflammation, cancer immunology, and cardiovascular inflammation, and has been shown to predict cardiovascular events.
Thomas Bernd Dschietzig +10 more
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Kynurenines and Neurofilament Light Chain in Multiple Sclerosis
Frontiers in Neuroscience, 2021 Multiple sclerosis is an autoimmune, demyelinating, and neurodegenerative disease of the central nervous system. In recent years, it has been proven that the kynurenine system plays a significant role in the development of several nervous system ...
Dániel Pukoli +5 more
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The Kynurenine Pathway: A Finger in Every Pie
Molecular Psychiatry, 2019 The kynurenine pathway (KP) plays a critical role in generating cellular energy in the form of nicotinamide adenine dinucleotide (NAD+). Because energy requirements are substantially increased during an immune response, the KP is a key regulator of the ...
J. Savitz
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IDO/kynurenine pathway in cancer: possible therapeutic approaches
Journal of Translational Medicine, 2022 Cancer is one of the leading causes of death in both men and women worldwide. One of the main changes associated with cancer progression, metastasis, recurrence, and chemoresistance is the change in the tumor immune microenvironment, especially ...
E. A. Abd El-Fattah
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Biomedicines, 2021 Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) differ for triggers, mode of start, associated symptoms, evolution, and biochemical traits.
Manuela Simonato +16 more
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Kynurenine Pathway Metabolites as Biomarkers in Alzheimer's Disease
Disease Markers, 2022 Alzheimer's disease (AD) is a progressive neurodegenerative disorder that deteriorates cognitive function. Patients with AD generally exhibit neuroinflammation, elevated beta-amyloid (Aβ), tau phosphorylation (p-tau), and other pathological changes in ...
Yuqing Liang +6 more
semanticscholar +1 more source
Kynurenines in CNS disease: regulation by inflammatory cytokines
Frontiers in Neuroscience, 2014 The kynurenine pathway metabolizes the essential amino acid tryptophan and generates a number of neuroactive metabolites collectively called the kynurenines.
Brian M Campbell +3 more
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Antioxidants, 2022 Acute respiratory distress syndrome (ARDS) involves dysregulated immune-inflammatory responses, characterized by severe oxidative stress and high mortality.
Li-Chung Chiu +6 more
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Kynurenine Acid - Metabolism And Regulation Of Kynurenine Pathway
Journal of Education, Health and Sport, 2017 Kozłowska Magdalena, Kozłowski Piotr. Kynurenine acid - metabolism and regulation of kynurenine pathway. Journal of Education, Health and Sport. 2017;7(7):888-895. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.891286 http://ojs.ukw.edu.pl/index.php/johs/article/view/4815 The journal has had 7 points in Ministry of Science ...
Piotr Kozłowski, Magdalena Kozlowska
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The kynurenine pathway in Alzheimer’s disease: a meta-analysis of central and peripheral levels [PDF]
Brazilian Journal of Psychiatry, 2023 Objective: Changes in the kynurenine pathway are recognized in psychiatric disorders, but their role in Alzheimer’s disease (AD) is less clear. We aimed to conduct a systematic review and meta-analysis to determine whether tryptophan and kynurenine ...
Brisa S. Fernandes +4 more
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