Results 51 to 60 of about 40,027 (305)

Kynurenine causes vasodilation and hypotension induced by activation of KCNQ-encoded voltage-dependent K+ channels

Journal of Pharmacological Sciences, 2015
Kynurenine is a potential contributor to hypotension in animal and human sepsis. The present study was designed to examine whether the voltage-dependent K+ channels encoded by the KCNQ gene family (Kv7 channels) mediate vasodilator effects of kynurenine ...
Kensuke Sakakibara, Guo-Gang Feng, Jiazheng Li, Takahiko Akahori, Yoshitaka Yasuda, Emi Nakamura, Noboru Hatakeyama, Yoshihiro Fujiwara, Hiroyuki Kinoshita   +8 more
doaj   +1 more source

Kynurenine pathway in kidney diseases [PDF]

Pharmacological Reports, 2021
AbstractKidney diseases have become one of the most common health care problems. Due to a growing number of advanced aged patients with concomitant disorders the prevalence of these diseases will increase over the coming decades. Despite available laboratory tests, accurate and rapid diagnosis of renal dysfunction has yet to be realized, and prognosis ...
Izabela Zakrocka, Wojciech Załuska
openaire   +3 more sources

Cerebrospinal fluid kynurenine and kynurenic acid concentrations are associated with coma duration and long-term neurocognitive impairment in Ugandan children with cerebral malaria

Malaria Journal, 2017
Background One-fourth of children with cerebral malaria (CM) retain cognitive sequelae up to 2 years after acute disease. The kynurenine pathway of the brain, forming neuroactive metabolites, e.g.
Dag Holmberg, Elisabeth Franzén-Röhl, Richard Idro, Robert O. Opoka, Paul Bangirana, Carl M. Sellgren, Ronny Wickström, Anna Färnert, Lilly Schwieler, Göran Engberg, Chandy C. John   +10 more
doaj   +1 more source

Gut–Brain Axis and Neuroinflammation: The Role of Gut Permeability and the Kynurenine Pathway in Neurological Disorders

Cellular and molecular neurobiology
The increasing prevalence of neurological disorders such as Alzheimer’s, Parkinson’s, and multiple sclerosis presents a significant global health challenge.
R.P. Kearns
semanticscholar   +1 more source

The Influence of Kynurenine Metabolites on Neurodegenerative Pathologies

International Journal of Molecular Sciences
As the kynurenine pathway’s links to inflammation, the immune system, and neurological disorders became more apparent, it attracted more and more attention. It is the main pathway through which the liver breaks down Tryptophan and the initial step in the
Suhrud Pathak, Rishi M. Nadar, Shannon Kim, Keyi Liu, Manoj Govindarajulu, Preston Cook, Courtney S. Watts Alexander, M. Dhanasekaran, Timothy Moore   +8 more
semanticscholar   +1 more source

The Footprint of Kynurenine Pathway in Cardiovascular Diseases

International Journal of Tryptophan Research, 2022
Kynurenine pathway is the main route of tryptophan metabolism and produces several metabolites with various biologic properties. It has been uncovered that several cardiovascular diseases are associated with the overactivation of kynurenine pathway and ...
Moein Ala, S. P. Eftekhar
semanticscholar   +1 more source

Indoleamine 2,3-Dioxygenase 1 Deletion–Mediated Kynurenine Insufficiency in Vascular Smooth Muscle Cells Exacerbates Arterial Calcification

Circulation, 2022
Background: IDO1 (indoleamine 2,3-dioxygenase 1) is the rate-limiting enzyme for tryptophan metabolism. IDO1 malfunction is involved in the pathogenesis of atherosclerosis.
Ouyang Liu, Changjiang Yu, Zhiyong Xie, Xiaoyan Su, Zengmei Xu, P. Song, Jian Li, Hui Huang, Ye Ding, M. Zou   +9 more
semanticscholar   +1 more source

Paliperidone Reversion of Maternal Immune Activation-Induced Changes on Brain Serotonin and Kynurenine Pathways

Frontiers in Pharmacology, 2021
Emerging evidence indicates that early-life exposure to environmental factors may increase the risk for schizophrenia via inflammatory mechanisms. Inflammation can alter the metabolism of tryptophan through the oxidative kynurenine pathway to compounds ...
Karina S. MacDowell, Karina S. MacDowell, Karina S. MacDowell, Eva Munarriz-Cuezva, Eva Munarriz-Cuezva, J. Javier Meana, J. Javier Meana, J. Javier Meana, Juan C. Leza, Juan C. Leza, Juan C. Leza, Jorge E. Ortega, Jorge E. Ortega, Jorge E. Ortega   +13 more
doaj   +1 more source

Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis

Advanced Science, EarlyView.
Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian, Jing Zhu, Jianhong Wu, Yan Zhang, Jianghua Chen, Huan Wang, Hengyan Liu, Ke Xu, Jiaxin Huang, Xiaoting Zhu, Yuanli Wei, Shilin Li, Tingting Wang, Xuan Huang, Qinghua Zou, Jie Zhang, Jiang Su, Xinming Du, Yaping Lu, Tianci Zhou, Yingtong Zhou, Minglong Tang, Bin Li, Xue Zhou, Qihao Wei, Qiulong Yan, Fanxin Zeng   +26 more
wiley   +1 more source

Concentrations of neopterin, kynurenine and tryptophan in wound secretions of patients with breast cancer and malignant melanoma: a pilot study

Pteridines, 2017
The aim of the present pilot study was to investigate the concentrations of neopterin, kynurenine and tryptophan in wound secretion in patients undergoing surgery for breast cancer or malignant melanoma.
Mergancová Jana, Javorská Lenka, Šiller Jiří, Sákra Lukáš, Mergancová Jindřiška, Solichová Dagmar, Krčmová Lenka Kujovská, Melichar Bohuslav, Mohelníková-Duchoňová Beatrice, Študentová Hana, Klos Dušan   +10 more
doaj   +1 more source