Results 51 to 60 of about 48,449 (279)

A deep insight into the sialome of male and female aedes aegypti mosquitoes [PDF]

, 2016
Only adult female mosquitoes feed on blood, while both genders take sugar meals. Accordingly, several compounds associated with blood feeding (i.e. vasodilators, anti-clotting, anti-platelets) are found only in female glands, while enzymes associated ...
ARCA', Bruno, Calvo, Eric, Martin Martin, Ines, Ribeiro, José M. C.   +3 more
core   +4 more sources

Evaluating predictive markers for viral rebound and safety assessment in blood and lumbar fluid during HIV-1 treatment interruption [PDF]

, 2020
Background: Validated biomarkers to evaluate HIV-1 cure strategies are currently lacking, therefore requiring analytical treatment interruption (ATI) in study participants.
De Langhe, Nele, De Scheerder, Marie-Angélique, Fuchs, Dietmar, Gisslén, Magnus, Lemey, Philippe, Noppe, Ytse, Palmer, Sarah, Pelgrom, Jolanda, Rutsaert, Sofie, Trypsteen, Wim, Van Der Gucht, Beatrijs, Van Hecke, Clarissa, Van Wanzeele, Filip, Vandekerckhove, Linos, Vrancken, Bram, Zetterberg, Henrik   +15 more
core   +1 more source

Kynurenine Pathway Metabolites as Potential Clinical Biomarkers in Coronary Artery Disease

Frontiers in Immunology, 2022
Coronary artery disease (CAD) is one of the leading cause of mortality worldwide. Several risk factors including unhealthy lifestyle, genetic background, obesity, diabetes, hypercholesterolemia, hypertension, smoking, age, etc.
Renáta Gáspár, Renáta Gáspár, Dóra Halmi, Dóra Halmi, Virág Demján, Virág Demján, Róbert Berkecz, Márton Pipicz, Márton Pipicz, Tamás Csont, Tamás Csont   +10 more
doaj   +1 more source

Expression of Tryptophan 2,3-Dioxygenase in Metastatic Uveal Melanoma [PDF]

, 2020
Uveal melanoma (UM) is the most common primary eye malignancy in adults and up to 50% of patients subsequently develop systemic metastasis. Metastatic uveal melanoma (MUM) is highly resistant to immunotherapy.
Bhushan, Alok, Kaushal, Gagan, Lam, Bao, Link, Emma, Londin, Eric R, Orloff, Marlana, Rochani, Ankit, Sato, Takami, Terai, Mizue   +8 more
core   +1 more source

The kynurenine pathway as a therapeutic target in cognitive and neurodegenerative disorders [PDF]

, 2013
Understanding the neurochemical basis for cognitive function is one of the major goals of neuroscience, with a potential impact on the diagnosis, prevention and treatment of a range of psychiatric and neurological disorders.
Akagbosu, Akladios, Alexander, Alkondon, Alkondon, Alkondon, Amori, Andersen, Atlas, Autier, Backman, Beal, Benatti, Bonda, Breese, Carpenedo, Carpenedo, Casazza, Castellano, Ceresoli-Borroni, Cesura, Chess, Chess, Chess, Chiarugi, Chiarugi, Clark, Cochran, Cozzi, Cui, Daily, Dalley, Dantzer, Darlington, Darlington, Davidson, Deiana, Della Torre, DiNatale, Dobelis, Dounay, Eastman, Erhardt, Forrest, Forrest, Forrest, Forrest, Fukui, Gellert, Giordani, Giorgini, Gold, Graef, Guidetti, Guidetti, Guidetti, Guidetti, Guillemin, Guillemin, Hardingham, Hedges, Henderson, Heng, Hernandez, Heyes, Hilmas, Holtze, Jason, Jauch, Jentsch, Jurgens, Kalisch, Kandanearatchi, Kiank, Kihara, Kloet, Kocki, Konradsson-Geuken, Lawrence, Lawrence, Linderholm, Lindsley, Luchowski, Luchowski, Lupien, Marin, Mexal, Millan, Miller, Minzenberg, Miura, Moeller, Mok, Muchowski, Muchowski, Mueller, Muscatell, Myint, Nagy, Neill, Newcomer, Newcomer, Nilsson, Nilsson, Nozaki, O'Connor, Olsson, Onur, Owe-Young, Paterson, Pearson, Pechtel, Pellicciari, Pellicciari, Perkins, Pertovaara, Pevarello, Phillips, Pocivavsek, Pocivavsek, Popoli, Popoli, Potter, Rahman, Raison, Rassoulpour, Ren, Robert, Rodgers, Rossi, Ryu, Röver, Saito, Salazar, Sapko, Sarter, Sathyasaikumar, Sathyasaikumar, Schwarcz, Schwarcz, Schwarcz, Schwarcz, Shear, Speciale, Speciale, Stazka, Stazka, Stone, Stone, Stone, Stone, Stone, Stoy, Tadaiesky, Tatter, Teichberg, Teichberg, Ting, Trecartin, Tse, Varasi, Vezzani, Walker, Wang, Wang, Wejksza, Wejksza, Wonodi, Xu, Yamada, Yuen, Zisapel, Zmarowski   +172 more
core   +1 more source

The kynurenine pathway and the brain: challenges, controversies and promises [PDF]

, 2017
Research on the neurobiology of the kynurenine pathway has suffered years of relative obscurity because tryptophan degradation, and its involvement in both physiology and major brain diseases, was viewed almost exclusively through the lens of the well ...
Schwarcz, Robert, Stone, Trevor W.
core   +1 more source

Imbalanced Kynurenine Pathway in Schizophrenia [PDF]

International Journal of Tryptophan Research, 2014
Several studies suggest a role for kynurenic acid (KYNA) in the pathophysiology of schizophrenia. It has been proposed that increased brain KYNA levels in schizophrenia result from a pathological shift in the kynurenine pathway toward enhanced KYNA formation, away from the other branch of the pathway leading to quinolinic acid (QUIN).
Kegel, Magdalena E., Bhat, Maria, Skogh, Elisabeth, Samuelsson, Martin, Lundberg, Kristina, Dahl, Marja-Liisa, Sellgren, Carl, Schwieler, Lilly, Engberg, Göran, Schuppe-Koistinen, Ina, Erhardt, Sophie   +10 more
openaire   +4 more sources

Concentrations of neopterin, kynurenine and tryptophan in wound secretions of patients with breast cancer and malignant melanoma: a pilot study

Pteridines, 2017
The aim of the present pilot study was to investigate the concentrations of neopterin, kynurenine and tryptophan in wound secretion in patients undergoing surgery for breast cancer or malignant melanoma.
Mergancová Jana, Javorská Lenka, Šiller Jiří, Sákra Lukáš, Mergancová Jindřiška, Solichová Dagmar, Krčmová Lenka Kujovská, Melichar Bohuslav, Mohelníková-Duchoňová Beatrice, Študentová Hana, Klos Dušan   +10 more
doaj   +1 more source

Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes

Journal for ImmunoTherapy of Cancer, 2023
Background Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan-dioxygenase (TDO) are enzymes catabolizing the essential amino acid tryptophan into kynurenine.
Luc Pilotte, Benoit J Van den Eynde, Jingjing Zhu, Christine Sers, Marie Solvay, Pauline Holfelder, Simon Klaessens, Vincent Stroobant, Juliette Lamy, Stefan Naulaerts, Quentin Spillier, Raphaël Frédérick, Etienne De Plaen, Christiane A Opitz   +13 more
doaj   +1 more source

The role of kynurenine and kynurenine metabolites in psoriasis

Turkish Journal of Biochemistry
Abstract Objectives Psoriasis is a widespread immunological disease characterised by inflammation and primarily associated with skin and joint symptoms. The kynurenine pathway significantly influences inflammation and immune system activity.
Fikret Akyurek, Fatma Tuncez-Akyurek, Fatma Sengul   +2 more
openaire   +2 more sources