Results 71 to 80 of about 36,414 (201)

G protein-coupled receptor 35: an emerging target in inflammatory and cardiovascular disease [PDF]

, 2015
G protein-coupled receptor 35 (GPR35) is an orphan receptor, discovered in 1998, that has garnered interest as a potential therapeutic target through its association with a range of diseases.
Amanda E Mackenzie, Graeme eMilligan, Nina eDivorty, Nina eDivorty, Stuart A. Nicklin   +4 more
core   +3 more sources

Deep Learning Model Enables the Discovery of a Novel Immunotherapeutic Agent Regulating the Kynurenine Pathway [PDF]

, 2021
Jeong Hun Kim, Won-Suk Lee, Hye Jin Lee, Hannah Yang, Seung-Joon Lee, So Jung Kong, Soyeon Je, Hyun-Jin Yang, Jongsun Jung, Jae Kyung Cheon, Beodeul Kang, Hong Jae Chon, Chan Kim   +12 more
openalex   +1 more source

Cerebrospinal fluid kynurenine and kynurenic acid concentrations are associated with coma duration and long-term neurocognitive impairment in Ugandan children with cerebral malaria

Malaria Journal, 2017
Background One-fourth of children with cerebral malaria (CM) retain cognitive sequelae up to 2 years after acute disease. The kynurenine pathway of the brain, forming neuroactive metabolites, e.g.
Dag Holmberg, Elisabeth Franzén-Röhl, Richard Idro, Robert O. Opoka, Paul Bangirana, Carl M. Sellgren, Ronny Wickström, Anna Färnert, Lilly Schwieler, Göran Engberg, Chandy C. John   +10 more
doaj   +1 more source

Caenorhabditis elegans orthologs of human genes differentially expressed with age are enriched for determinants of longevity [PDF]

, 2017
We report a systematic RNAi longevity screen of 82 Caenorhabditis elegans genes selected based on orthology to human genes differentially expressed with age. We find substantial enrichment in genes for which knockdown increased lifespan.
Backer, G. (Grant), Bean, S. (Shannon), Corban, C. (Caroline), Johnson, A.D. (Andrew D.), Korstanje, R. (Ron), Liu, T. (Teresa), Meurs, J.B.J. (Joyce) van, Murabito, J. (Joanne), Peters, M.A.D. (Marjolein), Sheehan, S. (Susan), Sutphin, G.L. (George L.)   +10 more
core   +1 more source

Hepatic steatosis induced in C57BL/6 mice by a non-ß oxidizable fatty acid analogue is associated with reduced plasma kynurenine metabolites and a modified hepatic NAD+/NADH ratio

Lipids in Health and Disease, 2020
Background Non-alcoholic fatty liver disease is often associated with obesity, insulin resistance, dyslipidemia, and the metabolic syndrome in addition to mitochondrial dysfunction and nicotinamide adenine dinucleotide (NAD+) deficiency.
Rolf K. Berge, Daniel Cacabelos, Rosa Señarís, Jan Erik Nordrehaug, Ottar Nygård, Jon Skorve, Bodil Bjørndal   +6 more
doaj   +1 more source

Serum Metabolomic Profiling of Piglets Infected with Virulent Classical Swine Fever Virus [PDF]

, 2017
Citation: Gong, W. J., Jia, J. J., Zhang, B. K., Mi, S. J., Zhang, L., Xie, X. M., . . . Tu, C. C. (2017). Serum Metabolomic Profiling of Piglets Infected with Virulent Classical Swine Fever Virus. Frontiers in Microbiology, 8, 14. doi:10.3389/fmicb.2017.
Bikai Zhang, Changchun Tu, Changchun Tu, Huancheng Guo, Jishu Shi, Junjie Jia, Li Zhang, Shijiang Mi, Wenjie Gong, Wenjie Gong, Xiaoming Xie   +10 more
core   +2 more sources

Untargeted metabolomics of colonic digests reveals kynurenine pathway metabolites, dityrosine and 3-dehydroxycarnitine as red versus white meat discriminating metabolites [PDF]

, 2016
Epidemiological research has demonstrated that the consumption of red meat is an important risk factor for the development of colorectal cancer (CRC), diabetes mellitus and cardiovascular diseases.
De Smet, S., De Vos, W.H., Hemeryck, L.Y., Rombouts, C., Van Hecke, T., Vanhaecke, L.   +5 more
core   +2 more sources

THE KYNURENINE PATHWAY AND ITS ROLE IN GLIOBLASTOMA CELL MIGRATION [PDF]

, 2023
Diana Sirnikova, Jóhannes Reynisson, Anke Bruning-Richardson, Catherine Kirby   +3 more
openalex   +1 more source

A distinct profile of tryptophan metabolism along the kynurenine pathway downstream of Toll-like receptor activation in irritable bowel syndrome

Frontiers in Pharmacology, 2012
Irritable bowel syndrome (IBS), a disorder of the brain-gut axis, is characterised by the absence of reliable biological markers. Tryptophan is an essential amino acid that serves as a precursor to serotonin but which can alternatively be metabolised ...
Gerard eClarke, Gerard eClarke, Gerard eClarke, Declan P McKernan, Gabor eGaszner, Eamonn M Quigley, Eamonn M Quigley, John F Cryan, John F Cryan, Timothy G Dinan, Timothy G Dinan   +10 more
doaj   +1 more source

Combined Metabolomic Analysis of Plasma and Tissue Reveals a Prognostic Risk Score System and Metabolic Dysregulation in Esophageal Squamous Cell Carcinoma

Frontiers in Oncology, 2020
Background: Esophageal squamous cell carcinoma (ESCC) is a gastrointestinal malignancy with a poor prognosis. Although studies have shown metabolic reprogramming to be linked to ESCC development, no prognostic metabolic biomarkers or potential ...
Zhongjian Chen, Zhongjian Chen, Zhongjian Chen, Zhongjian Chen, Yalan Dai, Yalan Dai, Yalan Dai, Xiancong Huang, Xiancong Huang, Xiancong Huang, Keke Chen, Keke Chen, Keke Chen, Keke Chen, Yun Gao, Yun Gao, Yun Gao, Na Li, Na Li, Na Li, Ding Wang, Ding Wang, Ding Wang, Aiping Chen, Aiping Chen, Aiping Chen, Qingxia Yang, Yanjun Hong, Su Zeng, Weimin Mao, Weimin Mao, Weimin Mao   +31 more
doaj   +1 more source