Optimization of L-Citrulline Operon in Corynebacterium glutamicum for L-Citrulline Production
Processes, 2022 L-citrulline plays important roles in many physiological processes, and its application range is expanding rapidly. Corynebacterium glutamicum strains have the potential to be efficient L-citrulline producers. In this study, we performed optimization of L-citrulline biosynthesis operon in C. glutamicum ATCC13032 for L-citrulline production. Chromosomal
Zaiwei Man +4 more
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Nutritional L-Citrulline and Tetrahydrobiopterin in Peripheral Artery Disease: A Phase II Randomized Trial (CIPER Study). [PDF]
JACC AdvSedding D +27 more
europepmc +2 more sources
Pulmonary Circulation, 2021 The L-arginine precursor, L-citrulline, re-couples endothelial nitric oxide synthase, increases nitric oxide production, and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs.
Matthew S. Douglass +3 more
doaj +1 more source
L-Citrulline Protects Skeletal Muscle Cells from Cachectic Stimuli through an iNOS-Dependent Mechanism. [PDF]
PLoS ONE, 2015 Dietary L-citrulline is thought to modulate muscle protein turnover by increasing L-arginine availability. To date, the direct effects of increased L-citrulline concentrations in muscle have been completely neglected. Therefore, we determined the role of
Daniel J Ham +6 more
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l-Citrulline Supplementation: Impact on Cardiometabolic Health [PDF]
Nutrients, 2018 Diminished bioavailability of nitric oxide (NO), the gaseous signaling molecule involved in the regulation of numerous vital biological functions, contributes to the development and progression of multiple age- and lifestyle-related diseases. While l-arginine is the precursor for the synthesis of NO by endothelial-nitric oxide synthase (eNOS), oral l ...
Timothy Allerton +5 more
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Sodium-coupled neutral amino acid transporter 1 (SNAT1) modulates L-citrulline transport and nitric oxide (NO) signaling in piglet pulmonary arterial endothelial cells. [PDF]
PLoS ONE, 2014 There is evidence that impairments in nitric oxide (NO) signaling contribute to chronic hypoxia-induced pulmonary hypertension. The L-arginine-NO precursor, L-citrulline, has been shown to ameliorate pulmonary hypertension.
Anna Dikalova +5 more
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Citrulline a more suitable substrate than arginine to restore NO production and the microcirculation during endotoxemia. [PDF]
PLoS ONE, 2012 BACKGROUND: Impaired microcirculation during endotoxemia correlates with a disturbed arginine-nitric oxide (NO) metabolism and is associated with deteriorating organ function.
Karolina A P Wijnands +6 more
doaj +1 more source
Heliyon, 2021 In our previous study, we found that the vasodilation of retinal arterioles induced by acetylcholine and BMS-191011, a large-conductance Ca2+-activated K+ (BKCa) channel opener, were diminished in diabetic rats.
Asami Mori +7 more
doaj +1 more source
Journal of Pharmacological Sciences, 2015 l-Citrulline is an effective precursor of l-arginine produced by the l-citrulline/l-arginine cycle, and it exerts beneficial effects on the cardiovascular system by supporting enhanced nitric oxide (NO) production.
Asami Mori +5 more
doaj +1 more source
Watermelon Juice: Potential Functional Drink for Sore Muscle Relief in Athletes [PDF]
, 2013 L-Citrulline is an excellent candidate to reduce muscle soreness, and watermelon is a fruit rich in this amino acid. This study investigated the potential of watermelon juice as a functional drink for athletes.
Aguayo, Encarna +4 more
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