Results 31 to 40 of about 414,201 (353)

Efficient synthesis of L-lactic acid from glycerol by metabolically engineered Escherichia coli [PDF]

, 2013
Due to its abundance and low-price, glycerol has become an attractive carbon source for the industrial production of value-added fuels and chemicals. This work reports the engineering of E.
Blankschien, Matthew D, Clomburg, James M, Gonzalez, Ramon, Mazumdar, Suman   +3 more
core   +2 more sources

Elevated LDH greater than 400 U/L portends poorer overall survival in diffuse large B-cell lymphoma patients treated with CD19 CAR-T cell therapy in a real world multi-ethnic cohort

Experimental Hematology & Oncology, 2021
Anti-CD19 chimeric antigen receptor T-cell therapies have shown striking clinical activity in diffuse large B-cell lymphoma but robust biomarkers predictive of responsiveness are still needed.
Emma Rabinovich, Kith Pradhan, R. Alejandro Sica, Lizamarie Bachier-Rodriguez, Ioannis Mantzaris, Noah Kornblum, Aditi Shastri, Kira Gritsman, Mendel Goldfinger, Amit Verma, Ira Braunschweig   +10 more
doaj   +1 more source

l-Lactate generates hydrogen peroxide in purified rat liver mitochondria due to the putative l-lactate oxidase localized in the intermembrane space [PDF]

, 1922
In order to ascertain whether and how mitochondria can produce hydrogen peroxide (H2O2) as a result of l-lactate addition, we monitored H2O2 generation in rat liver mitochondria and in submitochondrial fractions free of peroxisomal and cytosolic ...
de Bari, Lidia, Valenti, Daniela, Atlante, Anna, Passarella, Salvatore   +3 more
core   +2 more sources

Serum lactate dehydrogenase is associated with impaired lung function: NHANES 2011-2012.

PLoS ONE, 2023
BackgroundSerum lactate dehydrogenase levels reflect disease status in a variety of organs, but its role in indicating pulmonary function is not yet clear.
Sheng Hu, Jiayue Ye, Qiang Guo, Sheng Zou, Wenxiong Zhang, Deyuan Zhang, Yang Zhang, Silin Wang, Lang Su, Yiping Wei   +9 more
doaj   +1 more source

L-(+)-lactate dehydrogenase deficiency is lethal in Streptococcus mutans [PDF]

Journal of Bacteriology, 1994
The previously cloned gene for L-(+)-lactate dehydrogenase (LDH) from Streptococcus mutans was mutagenized in vitro. An Escherichia coli transformant which expressed a thermolabile LDH activity was identified. The ldh(Ts) gene was introduced into S.
Jeffrey D. Hillman, Anping Chen, M J Duncan   +2 more
openaire   +3 more sources

Human d‐lactate dehydrogenase deficiency by LDHD mutation in a patient with neurological manifestations and mitochondrial complex IV deficiency

JIMD Reports, 2021
Background d‐lactate, one of the isomers of lactate, exists in a low concentration in healthy individuals and it can be oxidized to pyruvate catalyzed by d‐lactate dehydrogenase.
Anna Ka‐Yee Kwong, Sheila Suet‐Na Wong, Richard J. T. Rodenburg, Jan Smeitink, Godfrey Chi Fung Chan, Cheuk‐Wing Fung   +5 more
doaj   +1 more source

Protein Conformational Landscapes and Catalysis. Influence of Active Site Conformations in the Reaction Catalyzed by L-Lactate Dehydrogenase.

ACS Catalysis, 2015
In the last decade L-Lactate Dehydrogenase (LDH) has become an extremely useful marker in both clinical diagnosis and in monitoring the course of many human diseases. It has been assumed from the 80s that the full catalytic process of LDH starts with the
K. Świderek, I. Tuñón, S. Martí, V. Moliner   +3 more
semanticscholar   +1 more source

Erythrocytes as Carriers of Therapeutic Enzymes. [PDF]

, 2020
Therapeutic enzymes are administered for the treatment of a wide variety of diseases. They exert their effects through binding with a high affinity and specificity to disease-causing substrates to catalyze their conversion to a non-noxious product, to ...
Bax, BE
core   +1 more source

DIAGNOSTIC UTILITY OF SERUM LACTATE DEHYDROGENASE LEVELS (LDL) IN DIFFERENTIATING MEGALOBLASTIC ANEMIA FROM MYELODYSPLASTIC SYNDROMES IN PAKISTAN

Pakistan Armed Forces Medical Journal, 2021
Objective: To study the diagnostic utility of lactate dehydrogenase levels in differentiating megaloblastic anemia from myelodysplastic anemia in Pakistan. Study Design: Comparative cross-sectional study.
Faraz Ali Rana, Helen Mary Robert, Madiha Ilyas, Asad Mahmood, Muhammad Amir, Nabeela Khan   +5 more
doaj  

Colonocyte-derived lactate promotes E. coli fitness in the context of inflammation-associated gut microbiota dysbiosis

Microbiome, 2022
Background Intestinal inflammation disrupts the microbiota composition leading to an expansion of Enterobacteriaceae family members (dysbiosis). Associated with this shift in microbiota composition is a profound change in the metabolic landscape of the ...
Savannah J. Taylor, Maria G. Winter, Caroline C. Gillis, Laice Alves da Silva, Amanda L. Dobbins, Matthew K. Muramatsu, Angel G. Jimenez, Rachael B. Chanin, Luisella Spiga, Ernesto M. Llano, Vivian K. Rojas, Jiwoong Kim, Renato L. Santos, Wenhan Zhu, Sebastian E. Winter   +14 more
doaj   +1 more source