Results 161 to 170 of about 15,338,333 (210)
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Bioorganic & Medicinal Chemistry Letters, 1997
Abstract 5-Thia- l -pipecolic acid, (S)-1,3-thiazane-4-carboxylic acid (6), was synthesized and found to serve as an excellent substrate for Rhesus monkey liver l -pipecolate oxidase ( l -PO) and also to cause time-dependent, irreversible inactivation of the enzyme.
T.Mark Zabriskie, null Xi Liang
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Abstract 5-Thia- l -pipecolic acid, (S)-1,3-thiazane-4-carboxylic acid (6), was synthesized and found to serve as an excellent substrate for Rhesus monkey liver l -pipecolate oxidase ( l -PO) and also to cause time-dependent, irreversible inactivation of the enzyme.
T.Mark Zabriskie, null Xi Liang
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γ-l-Glutamyl-l-pipecolic acid in Gleditsia caspica
Phytochemistry, 1974Abstract y- l -Glutamyl- l -pipecolic acid has been isolated from seeds of Gleditsia caspica (L.) Desf. Proof of its structure was obtained by chromatographic and spectroscopic examination of the natural product and its hydrolytic products. The new compound is the first example of a naturally occurring γ-glutamyl imino acid.
Gaston Dardenne +2 more
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L-pipecolic acid production in thrA knockout Escherichia coli
2023L-pipecolic acid (L-PA) is a non-proteinogenic amino acid, however, it is an important precursor and a key ingredient of many pharmaceutically compound syntheses such as immunosuppressants and anesthetics. The production of amino acids via fermentation of microorganisms are getting attention, one of the widely used is an engineered E. coli.
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Chiral synthesis of 5-hydroxy-(L)-pipecolic acids from (L)-glutamic acid
Tetrahedron Letters, 1988Abstract A stereo- and enantio-specific synthesis of the naturally occurring cis-5-hydroxy-(L)-pipecolic acid (3) is described, starting from Z-(L)-glutamic acid; the key step involves cyclisation of a protected chlorohydrin, and also gives access to trans-5-hydroxy-(L)-pipecolic acid.
Patrick D Bailey, Justin S Bryans
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Chemischer Informationsdienst, 1982
AbstractDas aus Baikiea plurijuga isolierte L‐Baikiain wird nach Einführung der Schutzgruppe [→(I)] mit Hg(OAc)2 in die beiden Hydroxyderivate (II) und (III) übergeführt (Diskussion des Reaktionsmechanismus).
R. E. A. CALLENS +2 more
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AbstractDas aus Baikiea plurijuga isolierte L‐Baikiain wird nach Einführung der Schutzgruppe [→(I)] mit Hg(OAc)2 in die beiden Hydroxyderivate (II) und (III) übergeführt (Diskussion des Reaktionsmechanismus).
R. E. A. CALLENS +2 more
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Enzymatic hydroxylation of L-pipecolic acid by L-proline cis-4-hydroxylases and isomers separation
Biotechnology Letters, 2020Establish a complete and efficient method for the preparation of cis-5-hydroxy-L-pipecolic acids (cis-5HPA), including biotransformation and isomers separation and purification.For non-heme Fe(II)/α-KG-dependent dioxygenases, α-ketoglutarate (α-KG) has great influence on the stability of Fe(II) ions, which is also the basic of the hydroxylation ...
Fan Lu +7 more
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Bulletin des Sociétés Chimiques Belges, 1982
AbstractZ‐trans‐5‐OH‐L‐pipecolic acid together with Z‐cis‐4‐OH‐L‐pipecolic acid is obtained in a 7:3 ratio by reduction of the oxymercuration product of Z‐L‐baikiain (Z‐1, 2, 5, 6‐L‐tetrahydropyridine‐2‐carboxylic acid). The opposite composition ratio is obtained using mercuric trifluoroacetate, thus giving access to the preparation of either of the ...
Roland E. A. Callens +2 more
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AbstractZ‐trans‐5‐OH‐L‐pipecolic acid together with Z‐cis‐4‐OH‐L‐pipecolic acid is obtained in a 7:3 ratio by reduction of the oxymercuration product of Z‐L‐baikiain (Z‐1, 2, 5, 6‐L‐tetrahydropyridine‐2‐carboxylic acid). The opposite composition ratio is obtained using mercuric trifluoroacetate, thus giving access to the preparation of either of the ...
Roland E. A. Callens +2 more
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Effect of oral administration of L‐pipecolic acid on food intake in chicks and mice
Animal Science Journal, 2003AbstractIt has been demonstrated that L‐pipecolic acid (L‐PA), a major metabolic intermediate of L‐lysine (L‐Lys) in the brain, is involved in the functioning of the γ‐aminobutyric acid‐ergic system. Previous study has shown that intracerebroventricular injection of L‐PA suppressed feeding and induced sleep‐like behavior in neonatal chicks. The present
Tomo TAKAGI +8 more
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l-Pipecolic acid metabolism in human liver: l-α-aminoadipate δ-semialdehyde oxidoreductase
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1990A soluble enzyme that catalyzes the oxidation of L-alpha-aminoadipate delta-semialdehyde to L-alpha-aminoadipic acid in the presence of NAD+ has been isolated and characterized from human liver. This enzyme L-alpha-aminoadipic delta-semialdehyde oxidoreductase has been found to be localized in the cytosol using subcellular fractionation and marker ...
Y F, Chang, P, Ghosh, V V, Rao
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Metabolism and uptake of -pipecolic acid by brain and heart
Life Sciences, 1981Abstract Metabolism and uptake of L -[1- 14 C]pipecolate was studied in the rat through tail vein injection at low (30 μg/kg) and high (30 mg/kg) doses. No radioactive compound other than L -pipecolate was detected in the brain or heart samples 0.5 to 60 min after injection. The contents of L -pipecolate in the brain dropped rapidly to
A K, Charles, Y F, Chang
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