Results 21 to 30 of about 288,915 (310)

Lactic Acidosis Together with GM-CSF and M-CSF Induces Human Macrophages toward an Inflammatory Protumor Phenotype

Cancer immunology research, 2020
Tumor-derived lactic acid induces human monocytes to differentiate into macrophages with inflammatory immunoregulatory properties, similar to those of macrophages in established tumors.
Léa Paolini, C. Adam, C. Beauvillain, L. Preisser, Simon Blanchard, P. Pignon, V. Seegers, L. Chevalier, M. Campone, R. Wernert, V. Verrielle, P. Raro, N. Ifrah, V. Lavoué, P. Descamps, A. Morel, V. Catros, G. Tcherkez, G. Lenaers, C. Bocca, J. Kouassi Nzoughet, V. Procaccio, Y. Delneste, P. Jeannin   +23 more
semanticscholar   +1 more source

A Study of Associations Between Plasma Metformin Concentration, Lactic Acidosis, and Mortality in an Emergency Hospitalization Context.

Critical Care Medicine, 2020
OBJECTIVES To determine the plasma metformin concentration threshold associated with lactic acidosis and analyze the outcome in metformin-treated patients with lactic acidosis hospitalized in an emergency context. DESIGN A retrospective, observational,
Y. Bennis, Sandra Bodeau, B. Batteux, V. Gras-Champel, K. Masmoudi, J. Maizel, Marc E. De Broe, J. Lalau, A. Lemaire‐Hurtel   +8 more
semanticscholar   +1 more source

Lactic acidosis induces resistance to the pan-Akt inhibitor uprosertib in colon cancer cells

British Journal of Cancer, 2020
Background Akt signalling regulates glycolysis and drives the Warburg effect in cancer, thus decreased glucose utilisation is a pharmacodynamic marker of Akt inhibition.
Emily M. E. Barnes, Yitao Xu, A. Benito, Lili Herendi, A. Siskos, E. Aboagye, A. Nijhuis, H. Keun   +7 more
semanticscholar   +1 more source

Lactic Acidosis [PDF]

New England Journal of Medicine, 2014
Lactic acidosis results from the accumulation of lactate and protons in the body fluids and is often associated with poor clinical outcomes. The effect of lactic acidosis is governed by its severity and the clinical context. Mortality is increased by a factor of nearly three when lactic acidosis accompanies low-flow states or sepsis,1 and the higher ...
Ingelfinger, Julie R, Kraut, Jeffrey A, Madias, Nicolaos E   +2 more
openaire   +9 more sources

Hospitalization for Lactic Acidosis Among Patients With Reduced Kidney Function Treated With Metformin or Sulfonylureas

Diabetes Care, 2020
OBJECTIVE To compare the risk of lactic acidosis hospitalization between patients treated with metformin versus sulfonylureas following development of reduced kidney function.
Patricia Y. Chu, A. Hackstadt, J. Chipman, M. Griffin, A. Hung, R. Greevy, Carlos G. Grijalva, T. Elasy, C. Roumie   +8 more
semanticscholar   +1 more source

Hypoglycemia with lactic acidosis caused by a new MRPS2 gene mutation in a Chinese girl: a case report

BMC Endocrine Disorders, 2022
Background Mitochondrial ribosomal protein S2 (MRPS2) gene mutation, which is related to severe hypoglycemia and lactic acidosis, is rarely reported globally. Case presentation We report a case of a new MRPS2 gene mutation in a Chinese girl who presented
ChangZhi Liu, WeiRan Zhou, QuanE Liu, ZaiXin Peng   +3 more
doaj   +1 more source

Metformin, Sulfonylureas, or Other Antidiabetes Drugs and the Risk of Lactic Acidosis or Hypoglycemia [PDF]

, 2011
OBJECTIVE: Lactic acidosis has been associated with use of metformin. Hypoglycemia is a major concern using sulfonylureas. The aim of this study was to compare the risk of lactic acidosis and hypoglycemia among patients with type 2 diabetes using oral ...
Bodmer, Michael, Jick, Susan S., Krähenbühl, Stephan, Meier, Christian, Meier, Christoph R.   +4 more
core   +2 more sources

Metformin, chronic nephropathy and lactic acidosis: a multi-faceted issue for the nephrologist

JN. Journal of Nephrology (Milano. 1992), 2020
Metformin is currently considered a first-line therapy in type 2 diabetic patients. After issuing warnings for decades about the risks of lactic acidosis in patients with chronic nephropathy, metformin is now being re-evaluated.
F. Mariano, L. Biancone
semanticscholar   +1 more source

Circulating anions usually associated with the Krebs cycle in patients with metabolic acidosis [PDF]

, 2005
Introduction: Acute metabolic acidosis of non-renal origin is usually a result of either lactic or ketoacidosis, both of which are associated with a high anion gap.
Forni, L.G., Hilton, P.J., Lord, Gwyn A., McKinnon, W., Peron, J.M.R., Treacher, D.F.   +5 more
core   +2 more sources

Type B Lactic Acidosis in a Patient with Mantle Cell Lymphoma

Case Reports in Critical Care, 2023
Type B lactic acidosis is an uncommon medical emergency in which acid production overwhelms hepatic clearance. This specific etiology of lactic acidosis occurs without organ hypoperfusion and has been most commonly described in patients with hematologic ...
Ikemsinachi C. Nzenwa, Margaret Berquist, Toby J. Brenner, Aida Ansari, Hamid D. Al-Fadhl, Michael Aboukhaled, Shivani S. Patel, Ethan E. Peck, Mahmoud D. Al-Fadhl, Anthony V. Thomas, Nuha Zackariya, Mark M. Walsh, Jose A. Bufill   +12 more
doaj   +1 more source