Results 1 to 10 of about 7,301 (235)

Lactosylceramide contributes to mitochondrial dysfunction in diabetes [PDF]

Journal of Lipid Research, 2016
Sphingolipids have been implicated as key mediators of cell-stress responses and effectors of mitochondrial function. To investigate potential mechanisms underlying mitochondrial dysfunction, an important contributor to diabetic cardiomyopathy, we ...
Sergei A. Novgorodov, Christopher L. Riley, Jin Yu, Jarryd A. Keffler, Christopher J. Clarke, An O. Van Laer, Catalin F. Baicu, Michael R. Zile, Tatyana I. Gudz   +8 more
doaj   +4 more sources

The first pediatric anti-lactosylceramide antibody-positive encephalomyeloradiculoneuropathy

Heliyon, 2022
Introduction: The anti-lactosylceramide (LacCer) antibody is an anti-neutral glycolipid antibody that is involved in the pathogenesis of encephalomyeloradiculoneuropathy (EMRN).
Akiko Sasaki, Itaru Hayakawa, Tatsuro Mutoh, Yuichi Abe   +3 more
doaj   +4 more sources

Elastin peptides signaling relies on neuraminidase-1-dependent lactosylceramide generation. [PDF]

PLoS ONE, 2010
The sialidase activity of neuraminidase-1 (Neu-1) is responsible for ERK 1/2 pathway activation following binding of elastin peptide on the elastin receptor complex.
Anthony Rusciani, Laurent Duca, Hervé Sartelet, Aurore Chatron-Colliet, Hélène Bobichon, Dominique Ploton, Richard Le Naour, Sébastien Blaise, Laurent Martiny, Laurent Debelle   +9 more
doaj   +5 more sources

The Involvement of Lactosylceramide in Central Nervous System Inflammation Related to Neurodegenerative Disease

Frontiers in Aging Neuroscience, 2021
Neurodegenerative diseases are a class of slow-progressing terminal illnesses characterized by neuronal lesions, such as multiple sclerosis [MS, Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS)]. Their incidence
Wen Yu, Wen Yu, Jun Ying, Jun Ying, Xifeng Wang, Xing Liu, Xing Liu, Tiancheng Zhao, Sungtae Yoon, Qingcui Zheng, Qingcui Zheng, Yang Fang, Yang Fang, Danying Yang, Danying Yang, Fuzhou Hua, Fuzhou Hua   +16 more
doaj   +2 more sources

Sphingolipids in Gaucher disease: a systematic review [PDF]

Orphanet Journal of Rare Diseases
Gaucher disease (GD) is a rare lysosomal disorder of sphingolipid catabolism, characterised by a block in the degradation of glucosylceramide (GlcCer) to ceramide.
Ashleigh Lake, Maria Fuller
doaj   +2 more sources

Mac-/Lactosylceramide regulates intestinal homeostasis and secretory cell fate commitment by facilitating Notch signaling [PDF]

eLife
Cell-to-cell communication via Delta-Notch signaling is widely used in various tissues and organs to regulate development and patterning; however, the mechanisms regulating Notch signaling for precise cell fate decisions remain poorly understood. Similar
Kebei Tang, Xuewen Li, Jiulong Hu, Jingyuan Shi, Yumei Li, Yansu Chen, Chang Yin, Fengchao Wang, Rongwen Xi   +8 more
doaj   +2 more sources

Synthesis of Azide-Labeled β-Lactosylceramide Analogs Containing Different Lipid Chains as Useful Glycosphingolipid Probes [PDF]

Molecules
β-Lactosylceramide (β-LacCer) is not only a key intermediate in the biosynthesis of complex glycosphingolipids (GSLs) but also an important regulator of many biological processes.
Basant Mohamed, Rajendra Rohokale, Xin Yan, Amany M. Ghanim, Nermine A. Osman, Hanan A. Abdel-Fattah, Zhongwu Guo   +6 more
doaj   +2 more sources

Regulation of EMT-MET and chemoresistance by the Lc3Cer-synthase B3GNT5 [PDF]

BMC Cancer
Background Glycosphingolipids (GSL) are essential components of the plasma membrane where they are known to play key structural and functional roles and are known to influence molecular processes involved in cancer malignancy, including multi-drug ...
Laura E. Clark, Katherine Hylton Rorie, Amanda J. G. Dickinson, Santiago Lima   +3 more
doaj   +2 more sources

Lactosylceramide: Lateral Interactions with Cholesterol [PDF]

Biophysical Journal, 2006
Lactosylceramide (LacCer) is a key intermediate in glycosphingolipid metabolism and is highly enriched in detergent-resistant biomembrane fractions associated with microdomains, i.e., rafts and caveolae. Here, the lateral interactions of cholesterol with LacCers containing various homogeneous saturated (8:0, 16:0, 18:0, 24:0) or monounsaturated acyl ...
Zhai, Xiuhong, Li, Xin-Min, Momsen, Maureen M., Brockman, Howard L., Brown, Rhoderick E.   +4 more
openaire   +2 more sources

Inhibitory affinity modulation of FcγRIIA ligand binding by glycosphingolipids by inside-out signaling

Cell Reports, 2021
Summary: The interaction of the human FcγRIIA with immune complexes (ICs) promotes neutrophil activation and thus must be tightly controlled to avoid damage to healthy tissue.
Koshu Okubo, Michael D. Brenner, Xavier Cullere, Gurpanna Saggu, Myra L. Patchen, Nandita Bose, Saki Mihori, Zhou Yuan, Clifford A. Lowell, Cheng Zhu, Tanya N. Mayadas   +10 more
doaj   +1 more source