Results 181 to 190 of about 5,991 (236)
Impact of Klotho genotype on lactylation in Alzheimer's disease and mechanistic insights. [PDF]
Immun AgeingCai Y, Li L, Li Z.
europepmc +1 more source
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Lactate, histone lactylation and cancer hallmarks
Expert Reviews in Molecular Medicine, 2023Abstract Histone lactylation, an indicator of lactate level and glycolysis, has intrinsic connections with cell metabolism that represents a novel epigenetic code affecting the fate of cells including carcinogenesis. Through delineating the relationship between histone lactylation and cancer hallmarks, we propose histone lactylation as a novel ...
Xinyu Lv, Yingying Lv, Xiaofeng Dai
openaire +2 more sources
Lactylation: novel epigenetic regulatory and therapeutic opportunities
American Journal of Physiology-Endocrinology and Metabolism, 2023Lactate, which is an end product of glycolysis, has traditionally been considered a metabolic waste. However, numerous studies have demonstrated that lactate serves metabolic and nonmetabolic functions in physiological processes and multiple diseases. Cancer and pulmonary arterial hypertension have been shown to undergo metabolic reprogramming, which ...
Haoqin Fan +7 more
openaire +2 more sources
Science Signaling, 2019
Histone modifications derived from the metabolite lactate promote transcription of genes necessary for the resolution of inflammation.
openaire +1 more source
Histone modifications derived from the metabolite lactate promote transcription of genes necessary for the resolution of inflammation.
openaire +1 more source
Nuclear GTPSCS functions as a lactyl-CoA synthetase to promote histone lactylation and gliomagenesis
Cell MetabolismHistone lysine lactylation is a physiologically and pathologically relevant epigenetic pathway that can be stimulated by the Warburg effect-associated L-lactate. Nevertheless, the mechanism by which cells use L-lactate to generate lactyl-coenzyme A (CoA) and how this process is regulated remains unknown.
Hening Lin, Yingming Zhao
exaly +3 more sources
Uncovering ubiquitous protein lactylation
Nature Methods, 2022Xiaofeng Wu, W. Andy Tao
openaire +2 more sources
Lactylation and regulated cell death
Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchLactylation, a newly identified post-translational modification, entails the attachment of lactate to lysine residues within proteins, profoundly modulating diverse cellular mechanisms underlying regulated cell death (RCD). This modification encompasses two primary categories: histone lactylation and non-histone lactylation. Histone lactylation assumes
Wenlong, Zhang +7 more
openaire +2 more sources
Lactylation regulates cardiac function
Cell Research, 2023Shohini Ghosh-Choudhary, Toren Finkel
openaire +2 more sources