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Nuclear GTPSCS functions as a lactyl-CoA synthetase to promote histone lactylation and gliomagenesis
Cell MetabolismHistone lysine lactylation is a physiologically and pathologically relevant epigenetic pathway that can be stimulated by the Warburg effect-associated L-lactate. Nevertheless, the mechanism by which cells use L-lactate to generate lactyl-coenzyme A (CoA) and how this process is regulated remains unknown.
Yingming Zhao +2 more
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The role of lactylation in virology
VirologyLactylation, a novel post-translational protein modification, is increasingly recognized for its widespread occurrence on lysine residues in both histone and non-histone proteins. Recent research has primarily focused on its implications in specific human diseases, particularly cancer progression, metabolic disorders, neurodegenerative diseases, and ...
Sirui Wang, Leiliang Zhang
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Lactate and lactylation in tumor immunity
Frontiers of MedicineThe Warburg effect, originally discovered by Otto Warburg, refers to the metabolic reprogramming of tumor cells from aerobic oxidation to glycolysis, enabling rapid energy production to support their growth and metastasis. This process is accompanied by the massive production and accumulation of lactate both intracellularly and extracellularly.
Liu, Song +3 more
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Lactate, histone lactylation and cancer hallmarks
Expert Reviews in Molecular Medicine, 2023Abstract Histone lactylation, an indicator of lactate level and glycolysis, has intrinsic connections with cell metabolism that represents a novel epigenetic code affecting the fate of cells including carcinogenesis. Through delineating the relationship between histone lactylation and cancer hallmarks, we propose histone lactylation as a novel ...
Xinyu Lv, Yingying Lv, Xiaofeng Dai
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Journal of the American Oil Chemists' Society, 1963
AbstractA titrimetric method has been presented for the determination of lactic acid in lactylated monoglycerides and shortenings containing these products, when the only water soluble acid present is lactic acid. Analyses by this method: of knowns, samples from a material balance test, and commercial products, indicate that it is applicable to these ...
W. D. Pohle +2 more
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AbstractA titrimetric method has been presented for the determination of lactic acid in lactylated monoglycerides and shortenings containing these products, when the only water soluble acid present is lactic acid. Analyses by this method: of knowns, samples from a material balance test, and commercial products, indicate that it is applicable to these ...
W. D. Pohle +2 more
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Lactylation and regulated cell death
Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchLactylation, a newly identified post-translational modification, entails the attachment of lactate to lysine residues within proteins, profoundly modulating diverse cellular mechanisms underlying regulated cell death (RCD). This modification encompasses two primary categories: histone lactylation and non-histone lactylation. Histone lactylation assumes
Wenlong, Zhang +7 more
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The overview of lactylation in the placenta of preeclampsia
PlacentaPreeclampsia is a major challenge for obstetricians due to its severe impacts on maternal and fetal health. Lysine lactylation (Kla) derived from lactate is a novel type of post-translational modification which has been confirmed to affect the malignant progression of diseases as an epigenetic modifier.
Qiaoli Feng +9 more
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Science Signaling, 2019
Histone modifications derived from the metabolite lactate promote transcription of genes necessary for the resolution of inflammation.
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Histone modifications derived from the metabolite lactate promote transcription of genes necessary for the resolution of inflammation.
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PD-L1 Lactylation Overturned the Understanding of Lactylations in Hepatocellular Carcinoma
MedScienHepatocellular carcinoma (HCC) is a leading cause of cancer mortality, and tumor immune evasion mediated by the PD-1/PD-L1 checkpoint axis constitutes a critical therapeutic barrier. Accumulating evidence demonstrates that aberrant tumor metabolism, particularly lactate accumulation and the associated post-translational modification of lysine ...
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Lactylation and HCC progression
Nature Reviews Gastroenterology & Hepatology, 2023openaire +2 more sources