Results 151 to 160 of about 7,170 (205)

Lactylation in sepsis-associated acute kidney injury: regulatory mechanisms and therapeutic prospects. [PDF]

Front Mol Biosci
Zheng J, Zheng B, Liang Q.
europepmc   +1 more source

Metabolic-epigenetic crosstalk in latent autoimmune diabetes in adults: potential roles of lactate-induced histone lactylation in immune regulation and pancreatic β-cell fate. [PDF]

Front Endocrinol (Lausanne)
Zhang W, Wang X, He B, Xia Y, Cao Z, Xu S.   +5 more
europepmc   +1 more source

Integration of Single-Cell and Bulk RNA Sequencing Data to Identify Lactylation-Related Gene Signatures in Hepatic Ischemia-Reperfusion Injury Using Machine Learning Algorithms. [PDF]

Int J Mol Sci
Jing S, Zhu Z.
europepmc   +1 more source

Protein Lactylation Induced by Neural Excitation [PDF]

Cell Reports, 2021
Abstract Lactate is known to have diverse roles in the brain at the molecular and behavioral levels under both physiological and pathophysiological conditions, such as learning and memory and regulation of mood. Recently, a novel post-translational modification called lysine lactylation has been found in histone H3 of
Hikari Otabi, Kaoru Katoh, Hideo Hagihara   +2 more
exaly   +4 more sources

Nuclear GTPSCS Functions as a Lactyl-CoA Synthetase to Promote Histone Lactylation and Gliomagenesis

Cell Metabolism
Histone lysine lactylation is a physiologically and pathologically relevant epigenetic pathway that can be stimulated by the Warburg effect-associated L-lactate. Nevertheless, the mechanism by which cells use L-lactate to generate lactyl-coenzyme A (CoA) and how this process is regulated remains unknown.
Yingming Zhao, Xuelian Ren
exaly   +4 more sources