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Lactylation: novel epigenetic regulatory and therapeutic opportunities
American Journal of Physiology-Endocrinology and Metabolism, 2023Lactate, which is an end product of glycolysis, has traditionally been considered a metabolic waste. However, numerous studies have demonstrated that lactate serves metabolic and nonmetabolic functions in physiological processes and multiple diseases. Cancer and pulmonary arterial hypertension have been shown to undergo metabolic reprogramming, which ...
Haoqin Fan +7 more
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Science Signaling, 2019
Histone modifications derived from the metabolite lactate promote transcription of genes necessary for the resolution of inflammation.
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Histone modifications derived from the metabolite lactate promote transcription of genes necessary for the resolution of inflammation.
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Uncovering ubiquitous protein lactylation
Nature Methods, 2022Xiaofeng Wu, W. Andy Tao
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Lactylation and regulated cell death
Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchLactylation, a newly identified post-translational modification, entails the attachment of lactate to lysine residues within proteins, profoundly modulating diverse cellular mechanisms underlying regulated cell death (RCD). This modification encompasses two primary categories: histone lactylation and non-histone lactylation. Histone lactylation assumes
Wenlong, Zhang +7 more
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Lactylation regulates cardiac function
Cell Research, 2023Shohini Ghosh-Choudhary, Toren Finkel
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Journal of the American Oil Chemists' Society, 1963
AbstractA titrimetric method has been presented for the determination of lactic acid in lactylated monoglycerides and shortenings containing these products, when the only water soluble acid present is lactic acid. Analyses by this method: of knowns, samples from a material balance test, and commercial products, indicate that it is applicable to these ...
W. D. Pohle +2 more
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AbstractA titrimetric method has been presented for the determination of lactic acid in lactylated monoglycerides and shortenings containing these products, when the only water soluble acid present is lactic acid. Analyses by this method: of knowns, samples from a material balance test, and commercial products, indicate that it is applicable to these ...
W. D. Pohle +2 more
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1966
Publisher Summary This chapter describes the determination of lactyl-CoA dehydrase. The enzyme can be assayed spectrophotometrically with acrylyl-CoA as substrate. The rate of lactyl-CoA formation is determined continuously by conversion of this product to free lactate in the presence of acetate and CoA transphorase. The lactate is then oxidized with
R.L. Baldwin, W.A. Wood
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Publisher Summary This chapter describes the determination of lactyl-CoA dehydrase. The enzyme can be assayed spectrophotometrically with acrylyl-CoA as substrate. The rate of lactyl-CoA formation is determined continuously by conversion of this product to free lactate in the presence of acetate and CoA transphorase. The lactate is then oxidized with
R.L. Baldwin, W.A. Wood
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Lactylation and HCC progression
Nature Reviews Gastroenterology & Hepatology, 2023openaire +2 more sources
Nuclear GTPSCS functions as a lactyl-CoA synthetase to promote histone lactylation and gliomagenesis
Cell MetabolismHistone lysine lactylation is a physiologically and pathologically relevant epigenetic pathway that can be stimulated by the Warburg effect-associated L-lactate. Nevertheless, the mechanism by which cells use L-lactate to generate lactyl-coenzyme A (CoA) and how this process is regulated remains unknown.
Ruilong Liu +17 more
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Subcellular Proteomic Mapping of Lysine Lactylation
Journal of the American Society for Mass SpectrometryProtein lactylation is a novel post-translational modification (PTM) involved in many important physiological processes such as macrophage polarization, immune regulation, and tumor cell growth. However, traditional methodologies for studying lactylation have predominantly relied on peptide enrichment from whole-cell lysates, which tend to favor the ...
Qiuyu Bao +6 more
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