Results 101 to 110 of about 73,838 (343)

Finding Friends in the Crowd: Three-Dimensional Cliques of Topological Genomic Domains

open access: yesFrontiers in Genetics, 2019
The mammalian genome is intricately folded in a three-dimensional topology believed to be important for the orchestration of gene expression regulating development, differentiation and tissue homeostasis. Important features of spatial genome conformation
Philippe Collas   +4 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Estimating the impact of time-based road user charges on risk taking by drivers. [PDF]

open access: yes, 1997
This study, conducted for ethical reasons on a driving simulator, has indicated that drivers take more risks when they are being charged for their use of roadspace on the basis of time, than they do when they are not subject to such charges. This effect
Bonsall, P.W., Palmer, I.A.
core  

Discrete Gravity on Random Tensor Network and Holographic R\'enyi Entropy

open access: yes, 2017
In this paper we apply the discrete gravity and Regge calculus to tensor networks and Anti-de Sitter/conformal field theory (AdS/CFT) correspondence. We construct the boundary many-body quantum state $|\Psi\rangle$ using random tensor networks as the ...
Han, Muxin, Huang, Shilin
core   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

Comparison of PD-L1 Expression Status between Pure-Solid Versus Part-Solid Lung Adenocarcinomas

open access: yesBiomolecules, 2019
Although lung adenocarcinomas (LADs) with ground-glass opacity (GGO; part-solid tumors) have been shown to differ from those without GGO (pure-solid tumors) in clinicopathological features and prognoses, whether programmed death ligand-1 (PD-L1) protein ...
Kenichi Suda   +8 more
doaj   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

open access: yesFEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart   +7 more
wiley   +1 more source

Acute proximal LAD occlusion without ST-segment elevation [PDF]

open access: bronze, 2009
Gianaugusto Slavich   +2 more
openalex   +1 more source

State College Times, September 21, 1933 [PDF]

open access: yes, 1932
Volume 22, Issue 2https://scholarworks.sjsu.edu/spartandaily/12896/thumbnail ...
San Jose State University, School of Journalism and Mass Communications
core   +4 more sources

Home - About - Disclaimer - Privacy