Results 21 to 30 of about 17,219,459 (310)

Frequency of CD39+, LAG3+, and CTLA4+ Regulatory T Cells in Two Different Immunosuppressive Protocols in Renal Allograft Recipients (Sirolimus vs Mycophenolate mofetil): A Cohort Report [PDF]

Iranian Journal of Immunology, 2022
Background: Impaired renal function is considered as a significant risk factor for cardiovascular events in chronic kidney disease patients. Several immunosuppressive drugs are used in these patients, which necessitates to minimize the drug-related side ...
Yaghoub Mollaei-Kandelous, Pedram Ahmadpoor, Mohsen Nafar, Mohammad Reza Khatami, Samad Farashi Bonab, Nader Tajik, Mahdi Shekarabi, Aliakbar Amirzargar   +7 more
doaj   +1 more source

TIM-3 levels correlate with enhanced NK cell cytotoxicity and improved clinical outcome in AML patients

OncoImmunology, 2021
Accumulating evidence indicates that immune checkpoint inhibitors (ICIs) can restore CD8+ cytotoxic T lymphocyte (CTL) functions in preclinical models of acute myeloid leukemia (AML).
Jana Rakova, Iva Truxova, Peter Holicek, Cyril Salek, Michal Hensler, Lenka Kasikova, Josef Pasulka, Monika Holubova, Marek Kovar, Daniel Lysak, Justin P. Kline, Zdenek Racil, Lorenzo Galluzzi, Radek Spisek, Jitka Fucikova   +14 more
doaj   +1 more source

Expression of LAG-3 on B-lymphocytes as a marker for prediction of response to therapy in patients with chronic lymphocytic leukemia

Сибирский онкологический журнал, 2023
Purpose: to study the level of LAG-3 expression on B-lymphocytes and the feasibility of using it as a marker for predicting response to therapy in patients with chronic lymphocytic leukemia (CLL).Material and Methods.
O. N. Selyutina, I. B. Lysenko, N. K. Guskova, I. A. Novikova, E. Yu. Zlatnik, T. F. Pushkareva, N. V. Nikolaeva, I. A. Kamaeva, N. Yu. Samaneva, E. A. Kapuza   +9 more
doaj   +1 more source

PD-1 and LAG-3 as early prognostic markers in the treatment of patients with chronic lymphocytic leukemia

Онкогематология, 2023
Background. Recently, studies have been conducted all over the world to study the role of immune checkpoints in the pathogenesis of chronic lymphocytic leukemia (CLL) and the possibility of their use as prognostic markers.
O. N. Selyutina, I. B. Lysenko, N. K. Guskova, I. А. Novikova, E. Yu. Zlatnik, T. F. Pushkareva, N. V. Nikolaeva, I. A. Kamaeva, E. A. Kapuza, Ya. S. Gaysultanova, L. Ya. Rozenko   +10 more
doaj   +1 more source

Development of a LAG-3 immunohistochemistry assay for melanoma [PDF]

Journal of Clinical Pathology, 2022
Aims A robust immunohistochemistry (IHC) assay was developed to detect lymphocyte-activation gene 3 (LAG-3) expression by immune cells (ICs) in tumour tissues. LAG-3 is an immuno-oncology target with demonstrable clinical benefit, and there is a need for a standardised, well-characterised assay to measure its ...
Lori Johnson, Bryan McCune, Darren Locke, Cyrus Hedvat, John B. Wojcik, Caitlin Schroyer, Jim Yan, Krystal Johnson, Angela Sanders-Cliette, Sujana Samala, Lloye M. Dillon, Steven Anderson, Jeffrey Shuster   +12 more
openaire   +2 more sources

PD-1 and LAG-3 blockade improve anti-tumor vaccine efficacy

OncoImmunology, 2021
Concurrent blockade of different checkpoint receptors, notably PD-1 and CTLA-4, elicits greater anti-tumor activity for some tumor types, and the combination of different checkpoint receptor inhibitors is an active area of clinical research.
Christopher D. Zahm, Jena E Moseman, Lauren E. Delmastro, Douglas G. Mcneel   +3 more
doaj   +1 more source

Checkpoint molecules coordinately restrain hyperactivated effector T cells in the tumor microenvironment

OncoImmunology, 2020
The immune checkpoint blockade (ICB) immunotherapy has prolonged overall survival for cancer patients but the response rates are low. The resistance to ICB is likely due to compensatory upregulation of additional immune inhibitory molecules.
Min Yang, Wenwen Du, Lixian Yi, Shaoxian Wu, Chunyan He, Wensi Zhai, Cuihua Yue, Runzi Sun, Ashley V. Menk, Greg M. Delgoffe, Jingting Jiang, Binfeng Lu   +11 more
doaj   +1 more source

Adaptive and Innate Immune Cells in Fetal Human Cytomegalovirus-Infected Brains

Microorganisms, 2020
Background: The understanding of the pathogenesis of cytomegalovirus (CMV)-induced fetal brain lesions is limited. We aimed to quantify adaptive and innate immune cells and CMV-infected cells in fetal brains with various degrees of brain damage. Methods:
Yann Sellier, Florence Marliot, Bettina Bessières, Julien Stirnemann, Ferechte Encha-Razavi, Tiffany Guilleminot, Nacilla Haicheur, Franck Pages, Yves Ville, Marianne Leruez-Ville   +9 more
doaj   +1 more source

LAG-3 Regulates Plasmacytoid Dendritic Cell Homeostasis [PDF]

The Journal of Immunology, 2009
Abstract Lymphocyte activation gene 3 (LAG-3) is a CD4-related, activation-induced cell surface molecule expressed by various lymphoid cell types and binds to MHC class II with high affinity. We have previously shown that LAG-3 negatively regulates the expansion of activated T cells and T cell homeostasis, and is required for maximal ...
Creg J, Workman, Yao, Wang, Karim C, El Kasmi, Drew M, Pardoll, Peter J, Murray, Charles G, Drake, Dario A A, Vignali   +6 more
openaire   +2 more sources

The PD-1- and LAG-3-targeting bispecific molecule tebotelimab in solid tumors and hematologic cancers: a phase 1 trial

Nature Medicine, 2023
The bispecific molecule tebotelimab, which blocks both PD-1 and LAG-3, is well tolerated as a monotherapy and in combination with the anti-HER-2 antibody margetuximab and elicits encouraging clinical activity in solid tumors with high LAG-3 levels and/or
J. Luke, Manish R Patel, G. Blumenschein, E. Hamilton, B. Chmielowski, S. Ulahannan, R. Connolly, Cesar A. Santa-Maria, Jie Wang, S. Bahadur, A. Weickhardt, A. Asch, G. Mallesara, P. Clingan, M. Długosz-Danecka, M. Tomaszewska-Kiecana, H. Pylypenko, N. Hamad, H. Kindler, B. Sumrow, P. Kaminker, Francine Z Chen, Xiaoyu Zhang, Kalpana Shah, Douglas H. Smith, Anushka De Costa, Jonathan C. Li, Hua Li, Jichao Sun, Paul A. Moore   +29 more
semanticscholar   +1 more source