Exhaustion of Activated CD8 T Cells Predicts Disease Progression in Primary HIV-1 Infection [PDF]
, 2016 The rate at which HIV-1 infected individuals progress to AIDS is highly variable and impacted by T cell immunity. CD8 T cell inhibitory molecules are up-regulated in HIV-1 infection and associate with immune dysfunction.
Babiker, A +18 more
core +2 more sources
Role of LAG-3 in Regulatory T Cells [PDF]
Immunity, 2004 Regulatory T cells (Tregs) limit autoimmunity but also attenuate the magnitude of antipathogen and antitumor immunity. Understanding the mechanism of Treg function and therapeutic manipulation of Tregs in vivo requires identification of Treg-selective receptors.
Huang, Ching-Tai +13 more
openaire +2 more sources
Access to consciousness of briefly presented visual events is modulated by transcranial direct current stimulation of left dorsolateral prefrontal cortex [PDF]
, 2019 Adaptive behaviour requires the ability to process goal-relevant events at the expense of irrelevant ones. However, perception of a relevant visual event can transiently preclude access to consciousness of subsequent events — a phenomenon called ...
Conversi D. +3 more
core +1 more source
Scientific Reports, 2023 The landscape of current cancer immunotherapy is dominated by antibodies targeting PD-1/PD-L1 and CTLA-4 that have transformed cancer therapy, yet their efficacy is limited by primary and acquired resistance. The blockade of additional immune checkpoints,
Riyao Yang +14 more
semanticscholar +1 more source
“Two Minds Don’t Blink Alike”: The Attentional Blink Does Not Occur in a Joint Context [PDF]
, 2018 Typically, when two individuals perform a task together, each partner monitors the other partners' responses and goals to ensure that the task is completed efficiently. This monitoring is thought to involve a co-representation of the joint goals and task,
Constable, Merryn +2 more
core +1 more source
Lymphocyte Activation Gene 3 (LAG-3) modulates the ability of CD4 T-cells to be suppressed in vivo. [PDF]
PLoS ONE, 2014 Lymphocyte Activation Gene - 3 (LAG-3) is an immune checkpoint molecule that regulates both T-cell activation and homeostasis. However, the molecular mechanisms underlying LAG-3's function are generally unknown.
Nicholas M Durham +6 more
doaj +1 more source
Gatecrashing the Visual Cocktail Party: How Visual and Semantic Similarity Modulate the Own Name Benefit in the Attentional Blink [PDF]
, 2018 The "visual cocktail party effect" refers to superior report of a participant's own name, under conditions of inattention. An early selection account suggests this advantage stems from enhanced visual processing (Treisman, 1960; Shapiro, Caldwell ...
Cole, Geoff, Dent, Kevin
core +1 more source
Role of lymphocyte activation gene-3 (Lag-3) in conventional and regulatory T cell function in allogeneic transplantation. [PDF]
PLoS ONE, 2014 Lag-3 has emerged as an important molecule in T cell biology. We investigated the role of Lag-3 in conventional T cell (Tcon) and regulatory T cell (Treg) function in murine GVHD with the hypothesis that Lag-3 engagement diminishes alloreactive T cell ...
Emanuela I Sega +5 more
doaj +1 more source
Frontiers in Immunology, 2021 BackgroundTransarterial chemoembolization (TACE) stands for the most commonly utilized therapy for hepatocellular carcinoma (HCC) worldwide. This study was to explore the potential predictive and prognostic roles of LAG-3 and PD-L1 as serum biomarkers in
Mengzhou Guo +7 more
doaj +1 more source
LAG-3 expression in microglia regulated by IFN-γ/STAT1 pathway and metalloproteases
Frontiers in Cellular Neuroscience, 2023 Microglia are resident innate immune cells in the central nervous system (CNS) and play important roles in the development of CNS homeostasis. Excessive activation and neurotoxicity of microglia are observed in several CNS disorders, but the mechanisms ...
Yuta Morisaki +3 more
semanticscholar +1 more source