Results 131 to 140 of about 96,178 (343)

Spatial distribution of lamin A/C determines nuclear stiffness and stress-mediated deformation

bioRxiv, 2019
The nucleus is the largest organelle and information center of the cell; while we identify the diverse components of the cells as mechanotransduction elements, the deformation of the nucleus itself is emerging as a critical mechanosensory structure ...
Luv Kishore Srivastava, Zhaoping Ju, Ajinkya Ghagre, A. Ehrlicher   +3 more
semanticscholar   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Nuclear lamin A/C phosphorylation by loss of androgen receptor leads to cancer-associated fibroblast activation

Nature Communications
Alterations in nuclear structure and function are hallmarks of cancer cells. Little is known about these changes in Cancer-Associated Fibroblasts (CAFs), crucial components of the tumor microenvironment. Loss of the androgen receptor (AR) in human dermal
Soumitra Ghosh, Jovan Isma, Paola Ostano, Luigi Mazzeo, Annagiada Toniolo, Monalisa Das, Joni R. White, Christian Simon, G. Paolo Dotto   +8 more
doaj   +1 more source

DNA compaction by the higher-order assembly of PRH/Hex homeodomain protein oligomers [PDF]

, 2010
Protein self-organization is essential for the establishment and maintenance of nuclear architecture and for the regulation of gene expression. We have shown previously that the Proline-Rich Homeodomain protein (PRH/Hex) self-assembles to form oligomeric
A. Sawasdichai, A. Shukla, A. Soufi, Bess, Butcher, C. Smith, Cai, Cairns, Crompton, D'Elia, Dafforn, de Los Rios, Desjobert, Galande, Gaston, Gaston, Gaston, Goldman, Jennings, K. Gaston, Katsani, Larquet, Lennard, Luger, Luijsterburg, Martino, Mohd-Sarip, P. Noy, P.-S. Jayaraman, Puppin, Sekiya, Song, Soufi, Soufi, Soufi, T. Dafforn, Tanny, Thaw, Topisirovic, Vernon, Williams, Yasui   +41 more
core   +5 more sources

p53 induces senescence through Lamin A/C stabilization-mediated nuclear deformation

Cell Death and Disease, 2019
p53-mediated cellular senescence has been intensively investigated, because it is important for tumor suppressive function. In addition, p16/INK4A is well known to be critical for cellular senescence.
Min-Ho Yoon, So-mi Kang, Su-Jin Lee, Tae-Gyun Woo, A. Oh, Soyoung Park, N. Ha, Bum-Joon Park   +7 more
semanticscholar   +1 more source

Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolism, and Fibrosis via Piezo1–YAP Mechanotransduction

Advanced Science, EarlyView.
Progressive stiffening of the hepatic extracellular matrix and free fatty acid overload activate the mechanosensor Piezo1 in steatotic hepatocytes, inducing calcium influx and nuclear translocation of Yes‐associated protein. YAP‐dependent nuclear signaling further drives inflammatory and fibrotic gene programs, lipid metabolic reprogramming, and ...
Juan Ma, Ning Xie, Ziwei Wang, Xiru Liang, Yulong Han, Qiang Zhao, Ming Wang, Hongwei Lu, Wanyi Kou, William Alazawi, Jinhai Wang, Lu Li, Ning Liu, Na Liu, Haitao Shi, Feng Xu   +15 more
wiley   +1 more source

Nuclear envelope proteins and chromatin arrangement: a pathogenic mechanism for laminopathies

European Journal of Histochemistry, 2009
The involvement of the nuclear envelope in the modulation of chromatin organization is strongly suggested by the increasing number of human diseases due to mutations of nuclear envelope proteins.
NM Maraldi, G Lattanzi, C Capanni, M Columbaro, L Merlini, E Mattioli, P Sabatelli   +6 more
doaj   +1 more source

Lamin-B1 is a senescence-associated biomarker in clear-cell renal cell carcinoma

Oncology Letters, 2019
Clear-cell renal cell carcinoma (ccRCC) is a von-Hippel-Lindau gene (VHL) associated tumor disease. In addition to activating the hypoxia inducible factor (HIF) dependent oxygen-sensing pathway, VHL loss also has an impact on a HIF-independent senescence
Melissa Marie Radspieler, M. Schindeldecker, P. Stenzel, Sebastian Försch, K. Tagscherer, E. Herpel, M. Hohenfellner, G. Hatiboglu, W. Roth, S. Macher-Goeppinger   +9 more
semanticscholar   +1 more source

Bioprinted Excitable Tissues with Multistimulation Systems for Promoting Function and Maturation

Advanced NanoBiomed Research, EarlyView.
This review provides an overview of stimulation strategies used to enhance the functional maturation of bioprinted excitable tissues. It addresses key limitations in physiological performance of bioprinted excitable tissues, outlines major stimulation modalities—including electrical, mechanical, optical, magnetic, ultrasound, and hybrid—and examines ...
Uijung Yong, Jinseon Park, Jinah Jang
wiley   +1 more source

Lamin A/C and PI(4,5)P2—A Novel Complex in the Cell Nucleus

Cells
Lamins, the nuclear intermediate filaments, are important regulators of nuclear structural integrity as well as nuclear functional processes such as DNA transcription, replication and repair, and epigenetic regulations.
Sara Escudeiro-Lopes, Vlada V. Filimonenko, Lenka Jarolimová, Pavel Hozák   +3 more
doaj   +1 more source