Results 41 to 50 of about 52,713 (325)
Altered stability of nuclear lamin-B marks the onset of aging in male Drosophila.
PLoS ONE, 2022 Epigenetic alterations occur during aging, but it remains unclear what epigenetic features are associated with the onset of physiological decline in animals.
Wei-Qi Lin +3 more
doaj +1 more source
Ergodic Theory and Dynamical Systems, 2008 AbstractIn this paper we prove the equivalence of two definitions of laminated currents.
FORNÆSS, JOHN ERIK +2 more
openaire +3 more sources
Chromatin and lamin A determine two different mechanical response regimes of the cell nucleus
Molecular Biology of the Cell, 2017 Micromanipulation force measurements of single isolated nuclei at physiological strains and strain rates reveal two distinct cell nuclear mechanical regimes differentially governed by chromatin and lamin A.
Andrew D. Stephens +4 more
semanticscholar +1 more source
Lamin B1 decline underlies age‐related loss of adult hippocampal neurogenesis
EMBO Journal, 2020 Neurogenesis in the adult hippocampus declines with age, a process that has been implicated in cognitive and emotional impairments. However, the mechanisms underlying this decline have remained elusive. Here, we show that the age‐dependent downregulation
T. Bedrosian +12 more
semanticscholar +1 more source
In Practice, 2012 Laminitis is a common and painful condition of adult equids that often results in permanent lameness or euthanasia. In recent years, our knowledge of the condition has developed and this article discusses the current understanding of laminitis and approaches to its treatment and prevention.
openaire +3 more sources
Influences of lamin A levels on induction of pluripotent stem cells
Biology Open, 2012 Summary Lamin A is an inner nuclear membrane protein that maintains nuclear structure integrity, is involved in transcription, DNA damage response and genomic stability, and also links to cell differentiation, senescence, premature aging and associated ...
Bingfeng Zuo +7 more
doaj +1 more source
Journal of Translational Medicine, 2023 Background Dilated cardiomyopathy (DCM) is a severe, non-ischemic heart disease which ultimately results in heart failure (HF). Decades of research on DCM have revealed diverse aetiologies.
Chia Yee Tan +12 more
doaj +1 more source
Journal of Clinical Investigation, 2020 Lamin A is a component of the inner nuclear membrane that, together with epigenetic factors, organizes the genome in higher order structures required for transcriptional control.
Andrea Bianchi +17 more
semanticscholar +1 more source
PLoS ONE, 2012 Lamins' functions are regulated by phosphorylation at specific sites but our understanding of the role of such modifications is practically limited to the function of cdc 2 (cdk1) kinase sites in depolymerization of the nuclear lamina during mitosis.
Magdalena Zaremba-Czogalla +5 more
doaj +1 more source
Crucial Role of Lamin A/C in the Migration and Differentiation of MSCs in Bone
Cells, 2020 Lamin A/C, intermediate filament proteins from the nuclear lamina encoded by the LMNA gene, play a central role in mediating the mechanosignaling of cytoskeletal forces into nucleus.
Natividad Alcorta-Sevillano +3 more
semanticscholar +1 more source