Results 51 to 60 of about 21,188,703 (341)

Structure and stability of the lamin A tail domain and HGPS mutant [PDF]

, 2011
Hutchinson–Gilford progeria syndrome (HGPS) is a premature aging syndrome caused by the expression and accumulation of a mutant form of lamin A, Δ50 lamin A.
Buehler, Markus J, Dahl, Kris Noel, Kalinowski, Agnieszka, Qin, Zhao   +3 more
core   +1 more source

Reduced expression of lamin A/C correlates with poor histological differentiation and prognosis in primary gastric carcinoma

Journal of Experimental & Clinical Cancer Research, 2009
Background Lamin A/C is very important in DNA replication, RNA dependent transcription and nuclear stabilization. Reduced or absent lamin A/C expression has been found to be a common feature of a variety of different cancers.
Xu Dazhi, Weng Desheng, Wu Lirong, Wu Zhengrong, Geng Jian, Zhao Fei   +5 more
doaj   +1 more source

Neddylation modification regulates lamin B1 expression in breast cancer [PDF]

Zhongguo aizheng zazhi, 2022
Background and purpose: The role of neddylation modification in breast cancer has rarely been reported. Previous study found that neddylation modification blocking induced cellular senescence in breast cancer, however, the potential mechanism has not yet
JIA Xiaoqing, SUN Xiaoyin, JIANG Beiqi, MEI Zhangyi, FU Yun, ZHUANG Zhigang
doaj   +1 more source

Lamin A molecular compression and sliding as mechanisms behind nucleoskeleton elasticity

Nature Communications, 2019
Lamin A is a nuclear intermediate filament protein critical for nuclear architecture and mechanics and mutated in a wide range of human diseases. Yet little is known about the molecular architecture of lamins and mechanisms of their assembly. Here we use

semanticscholar   +1 more source

Perinuclear Lamin A and Nucleoplasmic Lamin B2 Characterize Two Types of Hippocampal Neurons through Alzheimer’s Disease Progression

International Journal of Molecular Sciences, 2020
Background. Recent reports point to a nuclear origin of Alzheimer’s disease (AD). Aged postmitotic neurons try to repair their damaged DNA by entering the cell cycle.
Laura Gil, S. Niño, É. Chi-Ahumada, Ildefonso Rodríguez-Leyva, C. Guerrero, Ana B Rebolledo, J. Arias, M. Jiménez-Capdeville   +7 more
semanticscholar   +1 more source

Influences of lamin A levels on induction of pluripotent stem cells

Biology Open, 2012
Summary Lamin A is an inner nuclear membrane protein that maintains nuclear structure integrity, is involved in transcription, DNA damage response and genomic stability, and also links to cell differentiation, senescence, premature aging and associated ...
Bingfeng Zuo, Jiao Yang, Fang Wang, Lei Wang, Yu Yin, Jiameng Dan, Na Liu, Lin Liu   +7 more
doaj   +1 more source

Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity

Journal of Translational Medicine, 2023
Background Dilated cardiomyopathy (DCM) is a severe, non-ischemic heart disease which ultimately results in heart failure (HF). Decades of research on DCM have revealed diverse aetiologies.
Chia Yee Tan, Pui Shi Chan, Hansen Tan, Sung Wei Tan, Chang Jie Mick Lee, Jiong-Wei Wang, Shu Ye, Hendrikje Werner, Ying Jie Loh, Yin Loon Lee, Matthew Ackers-Johnson, Roger S. Y. Foo, Jianming Jiang   +12 more
doaj   +1 more source

Exercise is Associated With Impaired Left Ventricular Systolic Function in Patients With Lamin A/C Genotype

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2020
Background Lamin A/C cardiomyopathy is a malignant and highly penetrant inheritable cardiomyopathy. Competitive sports have been associated with adverse events in these patients, but data on recreational exercise are lacking.
E. Skjølsvik, N. Hasselberg, L. Dejgaard, Øyvind H. Lie, K. Andersen, T. Holm, T. Edvardsen, K. Haugaa   +7 more
semanticscholar   +1 more source

Sequences within the C terminus of the metabotropic glutamate receptor 5 (mGluR5) are responsible for inner nuclear membrane localization [PDF]

, 2017
Traditionally, G-protein-coupled receptors (GPCR) are thought to be located on the cell surface where they transmit extracellular signals to the cytoplasm.
Harmon, Steven K., Jong, Yuh-Jiin I., Kumar, Vikas, O\u27Malley, Karen L., Sergin, Ismail   +4 more
core   +2 more sources

Interphase phosphorylation of lamin A

Journal of Cell Science, 2014
Nuclear lamins form the major structural elements comprising the nuclear lamina. While loss of nuclear structural integrity has been implicated as a key factor in the lamin A gene mutations causing laminopathies, the normal regulation of lamin A/C (LA/C) assembly and organization in interphase cells is still undefined.
Vitaly Kochin, Takeshi Shimi, Elin Torvaldson, Stephen A. Adam, Anne Goldman, Chan-Gi Pack, Johanna Melo-Cardenas, Susumu Y. Imanishi, Robert D. Goldman, John E. Eriksson   +9 more
openaire   +4 more sources