Results 41 to 50 of about 1,866,196 (278)
VRK2A is an A-type lamin–dependent nuclear envelope kinase that phosphorylates BAF
Molecular Biology of the Cell, 2017 By the use of comparative BioID of nuclear envelope (NE) proteins lamin A and Sun2, as well as a minimal inner nuclear membrane targeting motif, VRK2 is identified as a novel constituent of the NE.
Birendra Kc +8 more
semanticscholar +1 more source
A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A
EMBO Journal, 2022 Sirtuin 6 (SIRT6) is a deacylase and mono‐ADP ribosyl transferase (mADPr) enzyme involved in multiple cellular pathways implicated in aging and metabolism regulation.
M. Simon +31 more
semanticscholar +1 more source
Lamin A and Prelamin a Counteract Migration of Osteosarcoma Cells
Cells, 2020 A type lamins are fundamental components of the nuclear lamina. Changes in lamin A expression correlate with malignant transformation in several cancers. However, the role of lamin A has not been explored in osteosarcoma (OS).
Camilla Evangelisti +11 more
doaj +1 more source
The large fraction of heterochromatin in Drosophila neurons is bound by both B-type lamin and HP1a
Epigenetics & Chromatin, 2018 BackgroundIn most mammalian cell lines, chromatin located at the nuclear periphery is represented by condensed heterochromatin, as evidenced by microscopy observations and DamID mapping of lamina-associated domains (LADs) enriched in dimethylated Lys9 of
A. Pindyurin +8 more
semanticscholar +1 more source
Lamin A and telomere maintenance in aging: Two to Tango.
Mutation research, 2022 Lamin proteins which constitute the nuclear lamina in almost all higher eukaryotes, are mainly of two types A & B encoded by LMNA and LMNB1/B2 genes respectively.
Duhita Sengupta, K. Sengupta
semanticscholar +1 more source
Identification of a Novel Muscle A-type Lamin-interacting Protein (MLIP) [PDF]
Journal of Biological Chemistry, 2011 Mutations in the A-type lamin (LMNA) gene are associated with age-associated degenerative disorders of mesenchymal tissues, such as dilated cardiomyopathy, Emery-Dreifuss muscular dystrophy, and limb-girdle muscular dystrophy. The molecular mechanisms that connect mutations in LMNA with different human diseases are poorly understood.
Ahmady, Elmira +6 more
openaire +2 more sources
Journal of Biological Chemistry, 2018 Muscle-enriched lamin-interacting protein (Mlip) is an alternatively spliced gene whose splicing specificity is dictated by tissue type. MLIP is most abundantly expressed in brain, cardiac, and skeletal muscle.
Marie-Elodie Cattin +10 more
semanticscholar +1 more source
Frontiers in Cell and Developmental Biology, 2021 A-type lamins are the main structural components of the nucleus, which are mainly localized at the nucleus periphery. First of all, A-type lamins, together with B-type lamins and proteins of the inner nuclear membrane, form a stiff structure—the nuclear ...
A. Malashicheva, K. Perepelina
semanticscholar +1 more source
A-type lamins and cardiovascular disease in premature aging syndromes [PDF]
Current Opinion in Cell Biology, 2017 Lamin A is a nuclear intermediate filament protein with important structural and regulatory roles in most differentiated mammalian cells. Excessive accumulation of its precursor prelamin A or the mutant form called 'progerin' causes premature aging syndromes.
Dorado, Beatriz, Andres, Vicente
openaire +3 more sources
The nucleoplasmic interactions among Lamin A/C-pRB-LAP2α-E2F1 are modulated by dexamethasone
Scientific Reports, 2021 Ataxia telangiectasia (AT) is a rare genetic neurodegenerative disease. To date, there is no available cure for the illness, but the use of glucocorticoids has been shown to alleviate the neurological symptoms associated with AT.
Anastasia Ricci +4 more
doaj +1 more source