Results 51 to 60 of about 1,866,196 (278)
Frontiers in Cell and Developmental Biology, 2022 Invaginations of the nuclear membrane occur in different shapes, sizes, and compositions. Part of these pleiomorphic invaginations make up the nucleoplasmic reticulum (NR), while others are merely nuclear folds.
Merel Stiekema +16 more
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Biology Open, 2016 In higher eukaryotes, nuclear envelope (NE) disassembly allows chromatin to condense and spindle microtubules to access kinetochores. The nuclear lamina, which strengthens the NE, is composed of a polymer meshwork made of A- and B-type lamins.
Daisuke Hayashi +3 more
semanticscholar +1 more source
Lamin post-translational modifications: emerging toggles of nuclear organization and function.
TIBS -Trends in Biochemical Sciences. Regular ed, 2021 Nuclear lamins are ancient type V intermediate filaments with diverse functions that include maintaining nuclear shape, mechanosignaling, tethering and stabilizing chromatin, regulating gene expression, and contributing to cell cycle progression. Despite
Laura A Murray-Nerger, I. Cristea
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A-type lamin networks in light of laminopathic diseases
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2007 Lamins are major structural components of the lamina providing mechanical support for the nuclear envelope in vertebrates. A subgroup of lamins, the A-type lamins, are only expressed in differentiated cells and serve important functions both at the nuclear envelope and in the nucleoplasm in higher order chromatin organization and gene regulation ...
Vlcek, Sylvia, Foisner, Roland
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Circulation, 2021 Supplemental Digital Content is available in the text. Background: Hutchinson-Gilford progeria syndrome (HGPS) is a rare disorder characterized by premature aging and death mainly because of myocardial infarction, stroke, or heart failure. The disease is
A. Sánchez-López +17 more
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Role of A-type lamins in signaling, transcription, and chromatin organization [PDF]
Journal of Cell Biology, 2009 A-type lamins (lamins A and C), encoded by the LMNA gene, are major protein constituents of the mammalian nuclear lamina, a complex structure that acts as a scaffold for protein complexes that regulate nuclear structure and functions. Interest in these proteins has increased in recent years with the discovery that LMNA mutations cause a variety of ...
Andrés, Vicente +1 more
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Lamin B1 acetylation slows the G1 to S cell cycle transition through inhibition of DNA repair
Nucleic Acids Research, 2021 The integrity and regulation of the nuclear lamina is essential for nuclear organization and chromatin stability, with its dysregulation being linked to laminopathy diseases and cancer.
Laura A Murray-Nerger +4 more
semanticscholar +1 more source
Genomic structure of the mouse A‐type lamin gene locus encoding somatic and germ cell‐specific lamins [PDF]
FEBS Letters, 1995 Mouse A‐type lamin genes were isolated. Structural analyses revealed that all the three known mouse A‐type lamins (A, C and C2) were coded in a single genomic locus in a 22 kilobase DNA segment. The three lamins were coded in 12, 10 and 10 exons for A, C and C2, respectively, and shared 8 exons among them.
Nakajima, Noboru, Abe, Kenji
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Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis
Hepatology, EarlyView., 2022 EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu +16 more
wiley +1 more source
Scientific Reports, 2015 The nuclear lamina is a protein meshwork associated with the inner side of the nuclear envelope contributing structural, signalling and regulatory functions.
M. Kollmar
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