Results 11 to 20 of about 18,743 (257)
Nuclear lamins: Structure and function in mechanobiology
APL Bioengineering, 2022 Nuclear lamins are type V intermediate filament proteins that polymerize into complex filamentous meshworks at the nuclear periphery and in less structured forms throughout the nucleoplasm.
Amir Vahabikashi +3 more
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Post-Translational Modification of Lamins: Mechanisms and Functions
Frontiers in Cell and Developmental Biology, 2022 Lamins are the ancient type V intermediate filament proteins contributing to diverse biological functions, such as the maintenance of nuclear morphology, stabilization of chromatin architecture, regulation of cell cycle progression, regulation of spatial-
Mingyue Zheng +2 more
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LAP2alpha maintains a mobile and low assembly state of A-type lamins in the nuclear interior
eLife, 2021 Lamins form stable filaments at the nuclear periphery in metazoans. Unlike B-type lamins, lamins A and C localize also in the nuclear interior, where they interact with lamin-associated polypeptide 2 alpha (LAP2α).
Nana Naetar +8 more
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A novel role of lamins from genetic disease to cancer biomarkers
Oncology Reviews, 2016 Lamins are the key components of the nuclear lamina and by virtue of their interactions with chromatin and binding partners act as regulators of cell proliferation and differentiation.
Kunnathur Murugesan Sakthivel +1 more
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Scaffold, mechanics and functions of nuclear lamins
FEBS Letters, 2023 Nuclear lamins are type‐V intermediate filaments that are involved in many nuclear processes. In mammals, A‐ and B‐type lamins assemble into separate physical meshwork underneath the inner nuclear membrane, the nuclear lamina, with some residual fraction
A. Buxboim +6 more
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Journal of Cell Biology, 2021 Structured illumination microscopy, cryo-ET, and computational analyses reveal that nuclear pore complexes (NPCs) and specific lamins spatially distribute in a codependent manner.
Mark Kittisopikul +8 more
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Modulation of muscle redox and protein aggregation rescues lethality caused by mutant lamins
Redox Biology, 2021 Mutations in the human LMNA gene cause a collection of diseases called laminopathies, which includes muscular dystrophy and dilated cardiomyopathy. The LMNA gene encodes lamins, filamentous proteins that form a meshwork on the inner side of the nuclear ...
Gary S. Coombs +9 more
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Advancement of science, 2020 The cell nucleus is constantly subjected to externally applied forces. During metazoan evolution, the nucleus has been optimized to allow physical deformability while protecting the genome under load.
Oren Wintner +7 more
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Fundamenta Mathematicae, 2022 Thurston introduced \emph{invariant (quadratic) laminations} in his 1984 preprint as a vehicle for understanding the connected Julia sets and the parameter space of quadratic polynomials. Important ingredients of his analysis of the angle doubling map $ _2$ on the unit circle $\mathbb{S}^1$ were the Central Strip Lemma, non-existence of wandering ...
Bhattacharya, Sourav +2 more
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Cold Spring Harbor Perspectives in Biology, 2010 The nuclear lamins are type V intermediate filament proteins that are critically important for the structural properties of the nucleus. In addition, they are involved in the regulation of numerous nuclear processes, including DNA replication, transcription and chromatin organization.
Thomas, Dechat +4 more
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