Results 11 to 20 of about 27,962 (381)
Nuclear lamins: Structure and function in mechanobiology
APL Bioengineering, 2022 Nuclear lamins are type V intermediate filament proteins that polymerize into complex filamentous meshworks at the nuclear periphery and in less structured forms throughout the nucleoplasm.
Amir Vahabikashi +3 more
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LAP2alpha maintains a mobile and low assembly state of A-type lamins in the nuclear interior
eLife, 2021 Lamins form stable filaments at the nuclear periphery in metazoans. Unlike B-type lamins, lamins A and C localize also in the nuclear interior, where they interact with lamin-associated polypeptide 2 alpha (LAP2α).
Nana Naetar +8 more
doaj +2 more sources
Post-Translational Modification of Lamins: Mechanisms and Functions
Frontiers in Cell and Developmental Biology, 2022 Lamins are the ancient type V intermediate filament proteins contributing to diverse biological functions, such as the maintenance of nuclear morphology, stabilization of chromatin architecture, regulation of cell cycle progression, regulation of spatial-
Mingyue Zheng +2 more
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Mammalian telomeres and their partnership with lamins [PDF]
The Nucleus, 2016 Chromosome ends are complex structures, which require a panel of factors for their elongation, replication, and protection. We describe here the mechanics of mammalian telomeres, dynamics and maintainance in relation to lamins.
BURLA, ROMINA +2 more
core +2 more sources
The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of cellular senescence [PDF]
Open Biology, 2016 AKTIP is a shelterin-interacting protein required for replication of telomeric DNA. Here, we show that AKTIP biochemically interacts with A- and B-type lamins and affects lamin A, but not lamin C or B, expression.
Astrologo, Letizia +14 more
core +3 more sources
A Perspective on the Experimental Techniques for Studying Lamins [PDF]
Cells, 2017 Lamins are type V intermediate filaments that collectively form a meshwork underneath the inner nuclear membrane, called nuclear lamina. Furthermore, they are also present in the nucleoplasm. Lamins are experiencing a growing interest, since a wide range
Ilaria Pecorari +2 more
doaj +2 more sources
A novel role of lamins from genetic disease to cancer biomarkers
Oncology Reviews, 2016 Lamins are the key components of the nuclear lamina and by virtue of their interactions with chromatin and binding partners act as regulators of cell proliferation and differentiation.
Kunnathur Murugesan Sakthivel +1 more
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Role of lamins in 3D genome organization and global gene expression
Nucleus, 2019 Genome-wide mapping of lamin-B1-genome interactions has shown that gene-poor and transcriptionally inactive genomic regions are associated with the nuclear lamina.
Youngjo Kim, Xiaobin Zheng, Yixian Zheng
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Journal of Cell Biology, 2021 Structured illumination microscopy, cryo-ET, and computational analyses reveal that nuclear pore complexes (NPCs) and specific lamins spatially distribute in a codependent manner.
Mark Kittisopikul +8 more
semanticscholar +1 more source
Nuclear Lamins: Key Proteins for Embryonic Development
Biology, 2022 Lamins are essential components of the nuclear envelope and have been studied for decades due to their involvement in several devastating human diseases, the laminopathies.
Jasper Chrysolite Paul, Helena Fulka
doaj +1 more source