Results 31 to 40 of about 10,575 (278)

Nuclear lamina strain states revealed by intermolecular force biosensor

open access: yesNature Communications, 2023
Nuclear lamins have been considered an important structural element of the nucleus. The nuclear lamina is thought both to shield DNA from excessive mechanical forces and to transmit mechanical forces onto the DNA.
Brooke E. Danielsson   +8 more
doaj   +1 more source

Genome organization in cardiomyocytes expressing mutated A-type lamins

open access: yesFrontiers in Cell and Developmental Biology, 2022
Cardiomyopathy is a myocardial disorder, in which the heart muscle is structurally and functionally abnormal, often leading to heart failure. Dilated cardiomyopathy is characterized by a compromised left ventricular function and contributes significantly
Marie Kervella   +3 more
doaj   +1 more source

Persistence of laminations [PDF]

open access: yesBulletin of the Brazilian Mathematical Society, New Series, 2010
We present a modern proof of some extensions of the celebrated Hirsch-Pugh-Shub theorem on persistence of normally hyperbolic compact laminations. Our extensions consist of allowing the dynamics to be an endomorphism, of considering the complex analytic case and of allowing the laminations to be non compact.
openaire   +3 more sources

Nuclear envelope, chromatin organizers, histones, and DNA: The many achilles heels exploited across cancers

open access: yesFrontiers in Cell and Developmental Biology, 2022
In eukaryotic cells, the genome is organized in the form of chromatin composed of DNA and histones that organize and regulate gene expression. The dysregulation of chromatin remodeling, including the aberrant incorporation of histone variants and their ...
A. K. Balaji   +4 more
doaj   +1 more source

Low lamin A expression in lung adenocarcinoma cells from pleural effusions is a pejorative factor associated with high number of metastatic sites and poor Performance status.

open access: yesPLoS ONE, 2017
The type V intermediate filament lamins are the principal components of the nuclear matrix, including the nuclear lamina. Lamins are divided into A-type and B-type, which are encoded by three genes, LMNA, LMNB1, and LMNB2.
Elise Kaspi   +16 more
doaj   +1 more source

Characterization of lamin mutation phenotypes in Drosophila and comparison to human laminopathies. [PDF]

open access: yesPLoS ONE, 2007
Lamins are intermediate filament proteins that make up the nuclear lamina, a matrix underlying the nuclear membrane in all metazoan cells that is important for nuclear form and function.
Andrés Muñoz-Alarcón   +6 more
doaj   +1 more source

The Nuclear Envelope as a Regulator of Immune Cell Function

open access: yesFrontiers in Immunology, 2022
The traditional view of the nuclear envelope (NE) was that it represented a relatively inert physical barrier within the cell, whose main purpose was to separate the nucleoplasm from the cytoplasm.
Anna Selezneva   +2 more
doaj   +1 more source

Lamins in Lung Cancer: Biomarkers and Key Factors for Disease Progression through miR-9 Regulation?

open access: yesCells, 2018
Lung cancer represents the primary cause of cancer death in the world. Malignant cells identification and characterization are crucial for the diagnosis and management of patients with primary or metastatic cancers. In this context, the identification of
Julien Guinde   +8 more
doaj   +1 more source

Modulation of muscle redox and protein aggregation rescues lethality caused by mutant lamins

open access: yesRedox Biology, 2021
Mutations in the human LMNA gene cause a collection of diseases called laminopathies, which includes muscular dystrophy and dilated cardiomyopathy. The LMNA gene encodes lamins, filamentous proteins that form a meshwork on the inner side of the nuclear ...
Gary S. Coombs   +9 more
doaj  

Metabolic Dysfunction in Hutchinson–Gilford Progeria Syndrome

open access: yesCells, 2020
Hutchinson−Gilford Progeria Syndrome (HGPS) is a segmental premature aging disease causing patient death by early teenage years from cardiovascular dysfunction.
Ray Kreienkamp, Susana Gonzalo
doaj   +1 more source

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