Results 31 to 40 of about 10,575 (278)
Nuclear lamina strain states revealed by intermolecular force biosensor
Nuclear lamins have been considered an important structural element of the nucleus. The nuclear lamina is thought both to shield DNA from excessive mechanical forces and to transmit mechanical forces onto the DNA.
Brooke E. Danielsson+8 more
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Genome organization in cardiomyocytes expressing mutated A-type lamins
Cardiomyopathy is a myocardial disorder, in which the heart muscle is structurally and functionally abnormal, often leading to heart failure. Dilated cardiomyopathy is characterized by a compromised left ventricular function and contributes significantly
Marie Kervella+3 more
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Persistence of laminations [PDF]
We present a modern proof of some extensions of the celebrated Hirsch-Pugh-Shub theorem on persistence of normally hyperbolic compact laminations. Our extensions consist of allowing the dynamics to be an endomorphism, of considering the complex analytic case and of allowing the laminations to be non compact.
openaire +3 more sources
In eukaryotic cells, the genome is organized in the form of chromatin composed of DNA and histones that organize and regulate gene expression. The dysregulation of chromatin remodeling, including the aberrant incorporation of histone variants and their ...
A. K. Balaji+4 more
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The type V intermediate filament lamins are the principal components of the nuclear matrix, including the nuclear lamina. Lamins are divided into A-type and B-type, which are encoded by three genes, LMNA, LMNB1, and LMNB2.
Elise Kaspi+16 more
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Characterization of lamin mutation phenotypes in Drosophila and comparison to human laminopathies. [PDF]
Lamins are intermediate filament proteins that make up the nuclear lamina, a matrix underlying the nuclear membrane in all metazoan cells that is important for nuclear form and function.
Andrés Muñoz-Alarcón+6 more
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The Nuclear Envelope as a Regulator of Immune Cell Function
The traditional view of the nuclear envelope (NE) was that it represented a relatively inert physical barrier within the cell, whose main purpose was to separate the nucleoplasm from the cytoplasm.
Anna Selezneva+2 more
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Lamins in Lung Cancer: Biomarkers and Key Factors for Disease Progression through miR-9 Regulation?
Lung cancer represents the primary cause of cancer death in the world. Malignant cells identification and characterization are crucial for the diagnosis and management of patients with primary or metastatic cancers. In this context, the identification of
Julien Guinde+8 more
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Modulation of muscle redox and protein aggregation rescues lethality caused by mutant lamins
Mutations in the human LMNA gene cause a collection of diseases called laminopathies, which includes muscular dystrophy and dilated cardiomyopathy. The LMNA gene encodes lamins, filamentous proteins that form a meshwork on the inner side of the nuclear ...
Gary S. Coombs+9 more
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Metabolic Dysfunction in Hutchinson–Gilford Progeria Syndrome
Hutchinson−Gilford Progeria Syndrome (HGPS) is a segmental premature aging disease causing patient death by early teenage years from cardiovascular dysfunction.
Ray Kreienkamp, Susana Gonzalo
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