Results 31 to 40 of about 27,962 (381)
Myopathic lamin mutations cause reductive stress and activate the nrf2/keap-1 pathway. [PDF]
PLoS Genetics, 2015 Mutations in the human LMNA gene cause muscular dystrophy by mechanisms that are incompletely understood. The LMNA gene encodes A-type lamins, intermediate filaments that form a network underlying the inner nuclear membrane, providing structural support ...
George Dialynas +9 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance The nuclear lamina is an integral component of all metazoan cells. While the individual constituents of the nuclear lamina, the A- and B-type lamins, have been well studied, whether they exhibit a distinct spatial organization is unclear ...
Bruce Nmezi +14 more
semanticscholar +1 more source
F1000Research, 2016 Lamins are major components of the nuclear lamina, a network of proteins that supports the nuclear envelope in metazoan cells. Over the past decade, biochemical studies have provided support for the view that lamins are not passive bystanders providing ...
Sita Reddy, Lucio Comai
doaj +1 more source
Regulation of Lipid Metabolism by Lamin in Mutation-Related Diseases
Frontiers in Pharmacology, 2022 Nuclear lamins, known as type 5 intermediate fibers, are composed of lamin A, lamin C, lamin B1, and lamin B2, which are encoded by LMNA and LMNB genes, respectively.
Yue Peng +4 more
doaj +1 more source
Aging of Hutchinson-Gilford progeria syndrome fibroblasts is characterised by hyperproliferation and increased apoptosis [PDF]
, 2004 Hutchinson-Gilford progeria syndrome is a rare genetic disorder that mimics certain aspects of aging prematurely. Recent work has revealed that mutations in the lamin A gene are a cause of the disease.
Bridger, JM, Kill, IR
core +1 more source
Nuclear lamins and diabetes mellitus
STEMedicine, 2020 In metazoans, a thin filamentous network referred to as the nuclear lamina plays an essential role in providing mechanical support to the nucleus. The major constituent of the nuclear lamina is type V intermediate filament proteins that are collectively ...
Wei Xie, Brian Burke
doaj +1 more source
Drosophila Models Reveal Properties of Mutant Lamins That Give Rise to Distinct Diseases
Cells, 2023 Mutations in the LMNA gene cause a collection of diseases known as laminopathies, including muscular dystrophies, lipodystrophies, and early-onset aging syndromes.
Sydney G. Walker +4 more
doaj +1 more source
Mutant lamins cause nuclear envelope rupture and DNA damage in skeletal muscle cells
bioRxiv, 2018 Mutations in the LMNA gene, which encodes the nuclear envelope (NE) proteins lamins A/C, cause Emery–Dreifuss muscular dystrophy, congenital muscular dystrophy and other diseases collectively known as laminopathies.
Ashley J. Earle +9 more
semanticscholar +1 more source
Chromatin histone modifications and rigidity affect nuclear morphology independent of lamins
bioRxiv, 2017 Nuclear shape and architecture influence gene localization, mechanotransduction, transcription, and cell function. Abnormal nuclear morphology and protrusions termed “blebs” are diagnostic markers for many human afflictions including heart disease, aging,
Andrew D. Stephens +7 more
semanticscholar +1 more source
Ergodic Theory and Dynamical Systems, 2008 AbstractIn this paper we prove the equivalence of two definitions of laminated currents.
FORNÆSS, JOHN ERIK +2 more
openaire +3 more sources