Results 41 to 50 of about 18,743 (257)
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Genetic defects in nuclear lamins or reduced expression of nuclear lamins is accompanied by nuclear blebs and an increased susceptibility for nuclear membrane ruptures.
Natalie Y. Chen +6 more
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Lateral A11 type tetramerization in lamins.
Journal of Structural Biology, 2019 The assembly of intermediate filaments (IFs) including nuclear lamins is driven by specific interactions of the elementary coiled-coil dimers in both lateral and longitudinal direction. The assembly mode A11 is dependent on lateral tetramerization of the
A. V. Lilina +3 more
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Lamins in Lung Cancer: Biomarkers and Key Factors for Disease Progression through miR-9 Regulation?
Cells, 2018 Lung cancer represents the primary cause of cancer death in the world. Malignant cells identification and characterization are crucial for the diagnosis and management of patients with primary or metastatic cancers. In this context, the identification of
Julien Guinde +8 more
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Characterization of lamin mutation phenotypes in Drosophila and comparison to human laminopathies. [PDF]
PLoS ONE, 2007 Lamins are intermediate filament proteins that make up the nuclear lamina, a matrix underlying the nuclear membrane in all metazoan cells that is important for nuclear form and function.
Andrés Muñoz-Alarcón +6 more
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Genome Research, 2016 Lamins are components of the peripheral nuclear lamina and interact with heterochromatic genomic regions, termed lamina-associated domains (LADs).
K. Gesson +5 more
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Frontiers in Cell and Developmental Biology, 2022 In eukaryotic cells, the genome is organized in the form of chromatin composed of DNA and histones that organize and regulate gene expression. The dysregulation of chromatin remodeling, including the aberrant incorporation of histone variants and their ...
A. K. Balaji +4 more
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Mathematical Methods in the Applied Sciences, 2012 Laminates made of composite anisotropic layers have a large varieties of different possible elastic responses. Still remaining in the classical field of linear elasticity, it is possible to obtain, with laminates, elastic behaviors that are very strange and completely unusual not only for classical materials, like metallic alloys, but also for the same
openaire +3 more sources
Insight into the functional organization of nuclear lamins in health and disease.
Current Opinion in Cell Biology, 2018 Lamins are the main component of the nuclear lamina, a protein meshwork at the inner nuclear membrane which primarily provide mechanical stability to the nucleus. Lamins, type V intermediate filament proteins, are also involved in many nuclear activities.
M. Tatli, O. Medalia
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Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Need for NAD+: Focus on Striated Muscle Laminopathies
Cells, 2020 Laminopathies are a heterogeneous group of rare diseases caused by genetic mutations in the LMNA gene, encoding A-type lamins. A-type lamins are nuclear envelope proteins which associate with B-type lamins to form the nuclear lamina, a meshwork ...
Déborah Cardoso, Antoine Muchir
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