Results 41 to 50 of about 15,070 (269)

Aging of Hutchinson-Gilford progeria syndrome fibroblasts is characterised by hyperproliferation and increased apoptosis [PDF]

open access: yes, 2004
Hutchinson-Gilford progeria syndrome is a rare genetic disorder that mimics certain aspects of aging prematurely. Recent work has revealed that mutations in the lamin A gene are a cause of the disease.
Bridger, JM, Kill, IR
core   +1 more source

Low lamin A expression in lung adenocarcinoma cells from pleural effusions is a pejorative factor associated with high number of metastatic sites and poor Performance status.

open access: yesPLoS ONE, 2017
The type V intermediate filament lamins are the principal components of the nuclear matrix, including the nuclear lamina. Lamins are divided into A-type and B-type, which are encoded by three genes, LMNA, LMNB1, and LMNB2.
Elise Kaspi   +16 more
doaj   +1 more source

Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS [PDF]

open access: yes, 2018
Defects in stress response are main determinants of cellular senescence and organism aging. In fibroblasts from patients affected by Hutchinson-Gilford progeria, a severe LMNA-linked syndrome associated with bone resorption, cardiovascular disorders, and
Andrenacci, Davide   +13 more
core   +2 more sources

Lamins in Lung Cancer: Biomarkers and Key Factors for Disease Progression through miR-9 Regulation?

open access: yesCells, 2018
Lung cancer represents the primary cause of cancer death in the world. Malignant cells identification and characterization are crucial for the diagnosis and management of patients with primary or metastatic cancers. In this context, the identification of
Julien Guinde   +8 more
doaj   +1 more source

Characterization of lamin mutation phenotypes in Drosophila and comparison to human laminopathies. [PDF]

open access: yesPLoS ONE, 2007
Lamins are intermediate filament proteins that make up the nuclear lamina, a matrix underlying the nuclear membrane in all metazoan cells that is important for nuclear form and function.
Andrés Muñoz-Alarcón   +6 more
doaj   +1 more source

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

open access: yesHepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu   +16 more
wiley   +1 more source

Genomic instability and DNA replication defects in progeroid syndromes [PDF]

open access: yes, 2018
Progeroid syndromes induced by mutations in lamin A or in its interactors – named progeroid laminopathies – are model systems for the dissection of the molecular pathways causing physio- logical and premature aging.
Chiara Merigliano   +4 more
core   +1 more source

Nuclear envelope, chromatin organizers, histones, and DNA: The many achilles heels exploited across cancers

open access: yesFrontiers in Cell and Developmental Biology, 2022
In eukaryotic cells, the genome is organized in the form of chromatin composed of DNA and histones that organize and regulate gene expression. The dysregulation of chromatin remodeling, including the aberrant incorporation of histone variants and their ...
A. K. Balaji   +4 more
doaj   +1 more source

Strange Laminates

open access: yesMathematical Methods in the Applied Sciences, 2012
Laminates made of composite anisotropic layers have a large varieties of different possible elastic responses. Still remaining in the classical field of linear elasticity, it is possible to obtain, with laminates, elastic behaviors that are very strange and completely unusual not only for classical materials, like metallic alloys, but also for the same
openaire   +3 more sources

p53-sensitive epileptic behavior and inflammation in Ft1 hypomorphic mice [PDF]

open access: yes, 2018
Epilepsy is a complex clinical condition characterized by repeated spontaneous seizures. Seizures have been linked to multiple drivers including DNA damage accumulation.
Alessandro, Vercelli   +10 more
core   +2 more sources

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