Results 41 to 50 of about 27,962 (381)
In Practice, 2012 Laminitis is a common and painful condition of adult equids that often results in permanent lameness or euthanasia. In recent years, our knowledge of the condition has developed and this article discusses the current understanding of laminitis and approaches to its treatment and prevention.
openaire +3 more sources
Genomic instability and DNA replication defects in progeroid syndromes [PDF]
, 2018 Progeroid syndromes induced by mutations in lamin A or in its interactors – named progeroid laminopathies – are model systems for the dissection of the molecular pathways causing physio- logical and premature aging.
Chiara Merigliano +4 more
core +1 more source
Nuclear lamina strain states revealed by intermolecular force biosensor
Nature Communications, 2023 Nuclear lamins have been considered an important structural element of the nucleus. The nuclear lamina is thought both to shield DNA from excessive mechanical forces and to transmit mechanical forces onto the DNA.
Brooke E. Danielsson +8 more
doaj +1 more source
The laminA/NF-Y protein complex reveals an unknown transcriptional mechanism on cell proliferation [PDF]
, 2016 Lamin A is a component of the nuclear matrix that also controls proliferation by largely unknown mechanisms. NF-Y is a ubiquitous protein involved in cell proliferation composed of three subunits (-YA -YB -YC) all required for the DNA ...
Alonzi, Tonino +16 more
core +2 more sources
Lamins organize the global three-dimensional genome from the nuclear periphery
bioRxiv, 2017 Lamins are structural components of the nuclear lamina (NL) that regulate genome organization and gene expression, but the mechanism remains unclear.
Xiaobin Zheng +8 more
semanticscholar +1 more source
Genome organization in cardiomyocytes expressing mutated A-type lamins
Frontiers in Cell and Developmental Biology, 2022 Cardiomyopathy is a myocardial disorder, in which the heart muscle is structurally and functionally abnormal, often leading to heart failure. Dilated cardiomyopathy is characterized by a compromised left ventricular function and contributes significantly
Marie Kervella +3 more
doaj +1 more source
Pushing the (nuclear) envelope into meiosis. [PDF]
, 2013 A recent study shows that a short isoform of a mammalian nuclear lamin is important for homologous chromosome interactions during meiotic prophase in ...
Dernburg, Abby F
core +1 more source
Alterations to nuclear architecture and genome behavior in senescent cells. [PDF]
, 2007 The organization of the genome within interphase nuclei, and how it interacts with nuclear structures is important for the regulation of nuclear functions.
Abney J.R. +52 more
core +1 more source
Frontiers in Cell and Developmental Biology, 2022 In eukaryotic cells, the genome is organized in the form of chromatin composed of DNA and histones that organize and regulate gene expression. The dysregulation of chromatin remodeling, including the aberrant incorporation of histone variants and their ...
A. K. Balaji +4 more
doaj +1 more source
p53-sensitive epileptic behavior and inflammation in Ft1 hypomorphic mice [PDF]
, 2018 Epilepsy is a complex clinical condition characterized by repeated spontaneous seizures. Seizures have been linked to multiple drivers including DNA damage accumulation.
Alessandro, Vercelli +10 more
core +2 more sources